{"id":20948,"date":"2025-05-16T17:00:05","date_gmt":"2025-05-16T17:00:05","guid":{"rendered":"https:\/\/lpfch.org\/?p=20948"},"modified":"2025-05-22T18:17:30","modified_gmt":"2025-05-22T18:17:30","slug":"supercharging-car-t-cell-therapy","status":"publish","type":"post","link":"https:\/\/lpfch.org\/es\/impact-stories\/supercharging-car-t-cell-therapy\/","title":{"rendered":"Terapia de c\u00e9lulas T CAR superpotenciada"},"content":{"rendered":"<p><span data-contrast=\"auto\">En los \u00faltimos 50 a\u00f1os, los investigadores han logrado avances incre\u00edbles en el tratamiento del c\u00e1ncer pedi\u00e1trico. Mientras que a mediados de la d\u00e9cada de 1970, aproximadamente el 60% de los pacientes j\u00f3venes con c\u00e1ncer fallec\u00eda a causa de la enfermedad, hoy en d\u00eda, el 85% de los pacientes sobrevive. Este progreso solo es posible gracias a ensayos cl\u00ednicos dirigidos por centros m\u00e9dicos acad\u00e9micos como el Hospital Infantil Lucile Packard de Stanford.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">A pesar de estos avances, el c\u00e1ncer sigue siendo la principal causa de muerte por enfermedad en ni\u00f1os de 15 a\u00f1os o menos. Para quienes pueden curarse, los tratamientos severos suelen desencadenar problemas de salud m\u00e1s adelante en la vida, como da\u00f1o org\u00e1nico, infertilidad o c\u00e1nceres secundarios.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/CAR-T_Graphic_color_art.png\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-20955 size-full\" src=\"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/CAR-T_Graphic_color_art.png\" alt=\"\" width=\"1600\" height=\"1025\" \/><\/a><\/p>\n<p><em>Ilustraci\u00f3n de Alece Birnbach<\/em><\/p>\n<p><span data-contrast=\"none\">do<\/span><span data-contrast=\"none\">Dra. Crystal Mackall, la <\/span><i><span data-contrast=\"none\">Profesor de la familia Ernest y Amelia Gallo, <\/span><\/i><span data-contrast=\"none\">Profesor de pediatr\u00eda y medicina, y centro<\/span> <span data-contrast=\"none\">director del Instituto Parker para el C\u00e1ncer<\/span> <span data-contrast=\"none\">La inmunoterapia en Stanford Medicine est\u00e1 liderando el<\/span> <span data-contrast=\"none\">Cobrar por ofrecer esperanza a los ni\u00f1os que m\u00e1s la necesitan. Para m\u00e1s informaci\u00f3n<\/span> <span data-contrast=\"none\">Durante m\u00e1s de 40 a\u00f1os, Mackall ha sido pionero en el tratamiento del c\u00e1ncer.<\/span> <span data-contrast=\"none\">Inmunoterapia: un campo que aprovecha los propios recursos del cuerpo.<\/span> <span data-contrast=\"none\">c\u00e9lulas inmunitarias para combatir enfermedades. En 2017, Mackall lanz\u00f3<\/span> <span data-contrast=\"none\">El Centro de Terapia de C\u00e9lulas Cancerosas de Stanford para impulsar<\/span> <span data-contrast=\"none\">avances desde el laboratorio hasta las camas de los pacientes como<\/span> <span data-contrast=\"none\">lo m\u00e1s r\u00e1pido posible<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u201cStanford es, en mi opini\u00f3n, el lugar donde se realiza la ciencia m\u00e1s creativa del mundo\u201d, afirma Mackall. \u201cQuer\u00eda desarrollar terapias celulares aqu\u00ed porque sab\u00eda que podr\u00eda trabajar con algunas de las mentes m\u00e1s brillantes: investigadores interesados en temas como la biolog\u00eda sint\u00e9tica, la inteligencia artificial, la investigaci\u00f3n traslacional y la inmunolog\u00eda humana\u201d.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">El equipo de Mackall lidera mejoras revolucionarias en las terapias con c\u00e9lulas T con receptores de ant\u00edgenos quim\u00e9ricos (CAR). Este enfoque, que ha demostrado ser notablemente eficaz contra algunos tipos de c\u00e1ncer de la sangre, modifica el sistema inmunitario del paciente para que busque y destruya las c\u00e9lulas cancerosas. Actualmente, Mackall trabaja para que este tratamiento sea eficaz contra c\u00e1nceres s\u00f3lidos y tumores cerebrales, con especial atenci\u00f3n en ni\u00f1os. Mackall colabor\u00f3 con la Dra. Michelle Monje, PhD,... <\/span><i><span data-contrast=\"none\">Milan Gambhir Profesor de Neurooncolog\u00eda Pedi\u00e1trica, <\/span><\/i><span data-contrast=\"none\">sobre un gran avance en el uso de c\u00e9lulas T CAR para tratar el glioma pontino intr\u00ednseco difuso, un tumor cerebral pedi\u00e1trico que se consideraba universalmente mortal, hasta ahora.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Este avance fue impulsado por el amplio apoyo de los donantes, y Mackall sabe que es solo el comienzo. Est\u00e1 desarrollando lo que ella llama inmunoterapias de &quot;pr\u00f3xima generaci\u00f3n&quot;, aprovechando las tecnolog\u00edas actuales para hacerlas m\u00e1s seguras, eficaces y rentables.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Una de estas innovaciones est\u00e1 dise\u00f1ada para mejorar la longevidad, la seguridad y la eficacia de las terapias con c\u00e9lulas T CAR. Mackall y su equipo descubrieron que pod\u00edan usar un f\u00e1rmaco existente \u2014una pastilla contra la hepatitis aprobada por la FDA\u2014 para reactivar los CAR latentes despu\u00e9s de reinyectarlos al paciente.<\/span><i><span data-contrast=\"none\">&#039;<\/span><\/i><span data-contrast=\"none\">Este nuevo m\u00e9todo, denominado &quot;SNIP CAR T&quot;, les brinda un control sin precedentes no solo sobre cu\u00e1ndo y d\u00f3nde se aplica el tratamiento, sino tambi\u00e9n sobre el nivel de activaci\u00f3n.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u201cHemos creado una terapia de c\u00e9lulas T CAR &#039;controlada a distancia&#039; que se adapta a cada paciente\u201d, explica Mackall. \u201cLas c\u00e9lulas T CAR modificadas no solo son m\u00e1s seguras, sino tambi\u00e9n m\u00e1s potentes y vers\u00e1tiles que las c\u00e9lulas T CAR originales\u201d.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">La ciencia de vanguardia como la de Mackall requerir\u00e1 un s\u00f3lido apoyo de inversores con visi\u00f3n de futuro. Sin embargo, este tipo de apoyo puede ser dif\u00edcil de obtener a trav\u00e9s de las fuentes de financiaci\u00f3n tradicionales.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u201cLas empresas de capital riesgo y biofarmac\u00e9uticas no suelen invertir en enfermedades raras, y todos los c\u00e1nceres infantiles son enfermedades raras\u201d, explica. \u201cPero nuestro objetivo es hacer ciencia disruptiva. Queremos cambiar la forma en que se tratar\u00e1 a los pacientes en el futuro\u201d.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">El apoyo filantr\u00f3pico ha impulsado los descubrimientos de Mackall y ser\u00e1 crucial en su avance. Donantes como Chris Gallo, cuya familia cre\u00f3 una c\u00e1tedra financiada para Mackall, se comprometen a impulsar su importante labor. Gallo sabe que el progreso se acelerar\u00e1 a\u00fan m\u00e1s si otros fil\u00e1ntropos se suman.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">\u201cNuestra familia ha apoyado durante mucho tiempo la ciencia de vanguardia como la del Dr. Mackall, investigaciones que conducen a mejores tratamientos para ni\u00f1os\u201d, dice Gallo. \u201cNos enorgullece continuar este legado con nuestra filantrop\u00eda\u201d.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Con un \u00e9xito pionero y un sinf\u00edn de posibilidades, Mackall est\u00e1 marcando el rumbo hacia una nueva era de la medicina y un futuro m\u00e1s saludable para los ni\u00f1os.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\"> <\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>En los \u00faltimos 50 a\u00f1os, los investigadores han logrado avances incre\u00edbles en el tratamiento del c\u00e1ncer infantil. Mientras que aproximadamente 601.300 millones de j\u00f3venes pacientes con c\u00e1ncer fallecieron a causa de su enfermedad\u2026<\/p>","protected":false},"author":7,"featured_media":20951,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[148],"class_list":["post-20948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-the-news","health_topic-pediatric-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Supercharging CAR T-Cell Therapy - Lucile Packard Foundation for Children&#039;s Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lpfch.org\/es\/impact-stories\/supercharging-car-t-cell-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Supercharging CAR T-Cell Therapy\" \/>\n<meta property=\"og:description\" content=\"Over the past 50 years, researchers have made incredible progress in treating pediatric cancer. 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