{"id":4351,"date":"2023-08-22T20:50:34","date_gmt":"2023-08-22T20:50:34","guid":{"rendered":"https:\/\/lpfch.org\/from-loss-comes-hope\/"},"modified":"2025-05-28T21:42:33","modified_gmt":"2025-05-28T21:42:33","slug":"from-loss-comes-hope","status":"publish","type":"post","link":"https:\/\/lpfch.org\/es\/impact-stories\/from-loss-comes-hope\/","title":{"rendered":"De la p\u00e9rdida surge la esperanza"},"content":{"rendered":"

Una nueva inmunoterapia se muestra prometedora para pacientes con tumores cerebrales mortales.<\/em><\/h4>\n

Cuando Jace Ward lleg\u00f3 al Hospital Infantil Lucile Packard de Stanford en septiembre de 2020 para participar en un ensayo cl\u00ednico de una terapia novedosa, llevaba m\u00e1s de un a\u00f1o luchando contra un tumor cerebral mortal. Su diagn\u00f3stico fue glioma pontino intr\u00ednseco difuso (PGID), que los tratamientos convencionales contra el c\u00e1ncer no pueden curar. La enfermedad tiene una tasa de supervivencia a cinco a\u00f1os inferior al 1 %.<\/p>\n

No hab\u00eda esperanza para pacientes como Jace, hasta hace poco, cuando se convirti\u00f3 en uno de los primeros cuatro pacientes con DIPG, u otro c\u00e1ncer estrechamente relacionado que afecta la m\u00e9dula espinal, en recibir c\u00e9lulas inmunitarias dise\u00f1adas para combatir la enfermedad. Aunque todos los pacientes del ensayo fallecieron a causa de la enfermedad o sus complicaciones, tres de ellos experimentaron importantes beneficios cl\u00ednicos gracias a las c\u00e9lulas dise\u00f1adas.<\/p>\n

\u201cEstos cuatro pacientes son h\u00e9roes\u201d, afirma la investigadora principal del estudio, la neuroonc\u00f3loga pedi\u00e1trica Michelle Monje, MD, PhD. \u201cNos ense\u00f1aron much\u00edsimo, y ese conocimiento ya se est\u00e1 aplicando para ayudar a otros ni\u00f1os\u201d.<\/p>\n

La FDA aprob\u00f3 el uso de c\u00e9lulas inmunes dise\u00f1adas, tambi\u00e9n conocidas como c\u00e9lulas T con receptores de ant\u00edgenos quim\u00e9ricos o c\u00e9lulas CAR-T, para tratar c\u00e1nceres de sangre en 2017, pero la tecnolog\u00eda nunca antes hab\u00eda tenido \u00e9xito contra tumores s\u00f3lidos.<\/p>\n

Aunque el equipo de investigaci\u00f3n a\u00fan no ha conseguido una cura para este tipo de glioma, considera que sus hallazgos son un hito.<\/p>\n

\u201cObservamos una actividad antitumoral significativa con estas terapias con c\u00e9lulas CAR-T en esta temida enfermedad\u201d, afirma la Dra. Crystal Mackall, quien colabor\u00f3 con Monje en la nueva investigaci\u00f3n. Mackall es experta en inmunoterapia contra el c\u00e1ncer y profesora de Pediatr\u00eda y Medicina Interna de la C\u00e1tedra Ernest y Amelia Gallo. \u201cLos hallazgos son una se\u00f1al esperanzadora para muchos tipos de tumores cerebrales, no solo para este\u201d, a\u00f1ade.<\/p>\n

El trabajo de Mackall y Monje fue posible gracias al generoso apoyo filantr\u00f3pico de donantes, muchos de los cuales son padres impulsados por la p\u00e9rdida de su hijo debido a esta enfermedad y dedicados a encontrar una cura.<\/p>\n

El caso de Jace Ward<\/h3>\n

Jace ten\u00eda 20 a\u00f1os cuando le diagnosticaron el glioma a principios de 2019, tras unas semanas de alteraci\u00f3n de la visi\u00f3n perif\u00e9rica. \u00c9l y su familia quedaron impactados por el pron\u00f3stico: su neur\u00f3logo en Kansas predijo que le quedaban entre seis y nueve meses de vida. Recibi\u00f3 un f\u00e1rmaco de quimioterapia experimental por compasi\u00f3n y convivi\u00f3 con la enfermedad durante casi 14 meses antes de que surgiera la oportunidad de participar en el ensayo cl\u00ednico de Stanford.<\/p>\n

Para cuando \u00e9l y su madre, Lisa, llegaron a Stanford, el tumor estaba progresando. Jace sab\u00eda que era poco probable que el ensayo le salvara la vida. "Dijo: 'S\u00e9 que voy a morir y s\u00e9 que esto...<\/p>\n

\u00abAlg\u00fan d\u00eda la terapia ser\u00e1 lo que cure a otros ni\u00f1os\u00bb, recuerda Monje. \u00abEste joven de 21 a\u00f1os, fuerte y futbolista, me dijo: 'No quiero que sea un ni\u00f1o de 5 a\u00f1os el que tenga que morir primero'\u00bb.<\/p>\n

No puedo morir. Estoy ocupado.<\/h3>\n

Cuando Jace se uni\u00f3 al ensayo de c\u00e9lulas CAR-T, cursaba el tercer a\u00f1o en la Universidad Estatal de Kansas, donde estudiaba emprendimiento y derecho. Tras su diagn\u00f3stico, Jace se convirti\u00f3 en defensor de los ni\u00f1os con DIPG.<\/p>\n

\u201cJace habl\u00f3 en el Congreso, en los Institutos Nacionales de Salud y en foros virtuales sobre c\u00e1nceres poco frecuentes\u201d, dice Lisa.<\/p>\n

Jace colabor\u00f3 en campa\u00f1as que recaudaron m\u00e1s de 1 mill\u00f3n de d\u00f3lares para ampliar la investigaci\u00f3n del c\u00e1ncer y el acceso al tratamiento. Tambi\u00e9n colabor\u00f3 en el lanzamiento de una organizaci\u00f3n sin fines de lucro que ayuda a ni\u00f1os con tumores cerebrales a obtener opiniones de expertos sobre ensayos cl\u00ednicos en los que pueden participar.<\/p>\n

\u201cJace consolaba a sus amigos y familiares dici\u00e9ndoles: 'No puedo morir, estoy ocupado'\u201d, dice Lisa. \u201cEso se convirti\u00f3 en un mantra para \u00e9l\u201d.<\/p>\n

Una semana despu\u00e9s de que Jace recibi\u00f3 su primera infusi\u00f3n de c\u00e9lulas CAR-T, tuvo fiebre y presi\u00f3n arterial baja, signos de elevaci\u00f3n de citocinas y sus s\u00edntomas neurol\u00f3gicos empeoraron.<\/p>\n

Pero a las dos semanas, los s\u00edntomas remitieron y sinti\u00f3 m\u00e1s sensibilidad facial. Su forma de caminar, que antes era torpe, se normaliz\u00f3 casi por completo. Al mes, su examen neurol\u00f3gico tambi\u00e9n fue casi normal.<\/p>\n

\u201cVer a un joven con DIPG de r\u00e1pida progresi\u00f3n recuperar un examen neurol\u00f3gico casi normal es inaudito\u201d, dice Monje. \u201cSent\u00ed por primera vez que alg\u00fan d\u00eda \u00edbamos a curar esta enfermedad\u201d.<\/p>\n

Jace pudo cumplir su sue\u00f1o de ir al Super Bowl en febrero de 2021 con su padre, Roger, para ver a su querido equipo local, los Kansas City Chiefs. "Fue una gran liberaci\u00f3n para \u00e9l, un rayo de esperanza", dice Lisa. El 30 de junio de 2021, Jace fue hospitalizado en San Luis y falleci\u00f3 el 3 de julio, dejando atr\u00e1s a sus padres, hermano, hermana, cu\u00f1ada y sobrino, que estaban de luto.<\/p>\n

"\u00bfOjal\u00e1 estuviera aqu\u00ed, sin saber qu\u00e9 era el DIPG? Claro que s\u00ed", dice su madre. Pero su trabajo como defensores de los pacientes le ha dado paz y prop\u00f3sito. "El deseo de Jace de ayudar a los ni\u00f1os, su aut\u00e9ntica necesidad de hablar por ellos, me dio una idea del hombre en el que se hab\u00eda convertido".<\/p>","protected":false},"excerpt":{"rendered":"

Una nueva inmunoterapia se muestra prometedora para pacientes con tumores cerebrales mortales. Cuando Jace Ward lleg\u00f3 al Hospital Infantil Lucile Packard de Stanford en septiembre de 2020 para unirse\u2026<\/p>","protected":false},"author":17,"featured_media":15312,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[148,22],"class_list":["post-4351","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-the-news","category-patient-stories"],"acf":[],"yoast_head":"\nFrom Loss Comes Hope - Lucile Packard Foundation for Children's Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lpfch.org\/es\/impact-stories\/from-loss-comes-hope\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"From Loss Comes Hope\" \/>\n<meta property=\"og:description\" content=\"New immunotherapy shows promise for patients with deadly brain tumor. 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