{"id":3555,"date":"2014-08-21T00:26:35","date_gmt":"2014-08-21T00:26:35","guid":{"rendered":"https:\/\/lpfch.org\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/"},"modified":"2024-10-23T16:28:14","modified_gmt":"2024-10-23T16:28:14","slug":"many-minds-one-goal-toward-a-cure-for-childhood-cancer","status":"publish","type":"post","link":"https:\/\/lpfch.org\/ko\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/","title":{"rendered":"\ub9ce\uc740 \ub9c8\uc74c, \ud558\ub098\uc758 \ubaa9\ud45c: \uc18c\uc544\uc554 \uce58\ub8cc\ubc95\uc744 \ud5a5\ud574"},"content":{"rendered":"<p><span style=\"line-height: 1.538em;\">\uc554\uc740 \uc5b4\ub5bb\uac8c \uc2dc\uc791\ub420\uae4c\uc694? \uc2a4\ud0e0\ud37c\ub4dc \ub300\ud559\uad50 \uc554 \uc0dd\ubb3c\ud559\uc790 \uc904\ub9ac\uc5b8 \uc138\uc774\uc9c0 \ubc15\uc0ac\ub294 \uadf8\uc758 \uacbd\ub825\uc758 \ub9ce\uc740 \ubd80\ubd84\uc744 \uc774 \uadfc\ubcf8\uc801\uc778 \uc9c8\ubb38\uc744 \ud0d0\uad6c\ud558\ub294 \ub370 \ubc14\ucce4\uc2b5\ub2c8\ub2e4.<\/span><\/p>\n<p>\uc138\uc774\uc9c0\ub9cc\uc774 \uc774\ub7f0 \uc5f0\uad6c\ub97c \ud558\ub294 \uac83\uc740 \uc544\ub2d9\ub2c8\ub2e4. \uc2a4\ud0e0\ud3ec\ub4dc \uc758\ub300\uc758 \ub9ce\uc740 \uc5f0\uad6c\uc790\ub4e4\uc774 \ubc31\ud608\ubcd1, \ub9dd\ub9c9\ubaa8\uc138\ud3ec\uc885, \uace8\uc721\uc885, \uacb8\uc0c1 \uc801\ud608\uad6c \ube48\ud608 \ub4f1 \ub2e4\uc591\ud55c \uc18c\uc544\uc554\uacfc \ud608\uc561 \uc9c8\ud658\uc758 \uc6d0\uc778\uacfc \uce58\ub8cc\ubc95\uc744 \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<h2>\ub9ce\uc740 \ub9c8\uc74c<\/h2>\n<p>\uc138\uc774\uc9c0\uc5d0 \ub530\ub974\uba74 \uc554\uc740 \ud608\uc561, \uac04, \ub1cc \ubc0f \uae30\ud0c0 \uc131\uc219\ud55c \uc138\ud3ec\ub85c \ubcc0\ud615\ub420 \uc218 \uc788\ub294 \ub2a5\ub825\uc744 \uac00\uc9c4 \uc904\uae30\uc138\ud3ec\uc758 DNA\uc5d0\uc11c \uc2dc\uc791\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc744 \ubd84\ud654\ub77c\uace0 \ud569\ub2c8\ub2e4.<\/p>\n<p>&quot;\uc815\uc0c1\uc801\uc778 \uc904\uae30\uc138\ud3ec\ub294 \uc870\uc9c1\uc744 \ubcf5\uad6c\ud558\uace0 \uc720\uc9c0\ud558\ub294 \ub370 \uc0ac\uc6a9\ub420 \uc218 \uc788\ub294 \ubd84\ud654\ub41c \uc138\ud3ec\ub85c \ubd84\uc5f4\ud569\ub2c8\ub2e4.&quot;\ub77c\uace0 \uc18c\uc544\uc554 \uc0dd\ubb3c\ud559 \ubc0f \uc720\uc804\ud559 \ubd80\uad50\uc218\uc774\uc790 \ud0c0\uc2dc\uc544 &amp; \uc874 \ubaa8\uadf8\ub9ac\uc9c0 \uc18c\uc544 \uc911\uac1c\uc758\ud559 \uad50\uc218\uc778 \uc138\uc774\uc9c0 \ubc15\uc0ac\ub294 \uc124\uba85\ud569\ub2c8\ub2e4. &quot;\ud558\uc9c0\ub9cc \uc554\uc5d0\uc11c\ub294 \uc904\uae30\uc138\ud3ec\uac00 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc77c\uc73c\ud0a4\uace0 \ud1b5\uc81c\ud560 \uc218 \uc5c6\uc774 \ubd84\uc5f4\ud569\ub2c8\ub2e4. \uc815\uc0c1 \uc870\uc9c1\uc744 \ub9cc\ub4dc\ub294 \ub300\uc2e0, \uc138\ud3ec\ub294 \uc885\uc591\uc744 \ub9cc\ub4e4\uae30 \uc2dc\uc791\ud569\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uc815\uc0c1\uc801\uc778 \uc138\ud3ec \uc7ac\uc0dd\uacfc \ube44\uc815\uc0c1\uc801\uc778 \uc554 \uc99d\uc2dd \uc0ac\uc774\uc758 \ubbf8\ubb18\ud55c \uade0\ud615\uc744 \uc774\ud574\ud558\ub294 \ub370 \uad00\uc2ec\uc774 \uc788\uc2b5\ub2c8\ub2e4.&quot;<\/p>\n<p>\uc138\uc774\uc9c0\ub294 \uc18c\uc544\uc5d0\uc11c \uac00\uc7a5 \ud754\ud55c \uc548\uc554\uc778 \ub9dd\ub9c9\ubaa8\uc138\ud3ec\uc885\uc744 \uc720\ubc1c\ud558\ub294 \uc720\uc804\uc790\ub97c \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ubbf8\uad6d\uc5d0\uc11c \uc774 \uc9c8\ud658\uc73c\ub85c \uc9c4\ub2e8\ubc1b\uc740 \uc18c\uc544 10\uba85 \uc911 9\uba85\uc740 \uc644\uce58\ub418\uc9c0\ub9cc, \uac1c\ubc1c\ub3c4\uc0c1\uad6d\uc758 \uc0dd\uc874\uc728\uc740 \ud6e8\uc52c \ub0ae\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ub9dd\ub9c9\ubaa8\uc138\ud3ec\uc885\uc740 RB \uc720\uc804\uc790\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc778\ud574 \ubc1c\uc0dd\ud569\ub2c8\ub2e4. \uc138\uc774\uc9c0\ub294 \ucd5c\uadfc RB \uc720\uc804\uc790\uc640 \uadf8 \uacc4\uc5f4 \uc720\uc804\uc790\uac00 \ubd88\ud65c\uc131\ud654\ub418\uba74 \uac04\uc758 \uc904\uae30\uc138\ud3ec\uac00 \ube60\ub974\uac8c \uc99d\uc2dd\ud558\uc5ec \uac04\uc138\ud3ec\uc554(HCC)\uc774\ub77c\ub294 \uce58\uba85\uc801\uc778 \uc885\uc591\uc73c\ub85c \ubc1c\uc804\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ub610\ud55c Notch\ub77c\ub294 \ud2b9\uc815 \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uac00 \uc885\uc591\uc758 \uc131\uc7a5\uc744 \uc2e4\uc81c\ub85c \ub2a6\ucd9c \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\ub3c4 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \uacb0\ub860\uc801\uc73c\ub85c, Notch \ud65c\uc131\ub3c4\ub294 HCC \ud658\uc790\uc758 \uc0dd\uc874\uc728\uc744 \uc608\uce21\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc138\uc774\uc9c0\ub294 &quot;Notch \uacbd\ub85c\ub97c \uc774\ud574\ud558\uba74 \uc18c\uc544 \uc885\uc591\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\ub2e4&quot;\uace0 \uc124\uba85\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<h2>\ub9ce\uc740 \ub9c8\uc74c<\/h2>\n<p>\uc138\uc774\uc9c0\ub294 \ud604\uc7ac \uc12c\uc720\uce35\ud310\uc554\uc774\ub77c\ub294 \ud76c\uadc0 \uc18c\uc544 \uac04\uc138\ud3ec\uc554(HCC) \ud658\uc790 8\uba85\uc758 \uc870\uc9c1 \uc0d8\ud50c\uc744 \uac80\uc0ac\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\uc640 \uc2a4\ud0e0\ud37c\ub4dc \uc720\uc804\uccb4 \uae30\uc220 \uc13c\ud130\uc758 \ub3d9\ub8cc\ub4e4\uc740 \uc885\uc591 \uc138\ud3ec\uc758 DNA\uc640 \uac74\uac15\ud55c \uac04\uc758 DNA\ub97c \ube44\uad50\ud558\ub294 \ud798\ub4e0 \uc791\uc5c5\uc5d0 \ucc29\uc218\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&quot;\uc6b0\ub9ac\ub294 \uadf8\ub4e4\uc774 \uc5b4\ub5a4 \uc885\ub958\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c0\uace0 \uc788\ub294\uc9c0, \uc5b4\ub5bb\uac8c \uc2dc\uc791\ub418\ub294\uc9c0, \uadf8\ub9ac\uace0 \uc65c \uadf8\ub807\uac8c \ub4dc\ubb38\uc9c0 \uc54c\uc544\ub0b4\uace0\uc790 \ud569\ub2c8\ub2e4.&quot;\ub77c\uace0 \uc138\uc774\uc9c0\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uc774\ub7ec\ud55c \uc9c0\uc2dd\uc740 \uc18c\uc544\uc5d0\uc11c \ub2e4\ub978 \uc720\ud615\uc758 \uc554\uc744 \uc720\ubc1c\ud558\ub294 \uadfc\ubcf8\uc801\uc778 \uba54\ucee4\ub2c8\uc998\uc744 \uc774\ud574\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.&quot;<\/p>\n<p>\uc12c\uc720\uce35\uc0c1\uc554 \uc5f0\uad6c\ub294 \ucea0\ud37c\uc2a4 \uc804\uccb4\uc5d0 \uac78\uce5c \ub2e4\ud559\uc81c\uc801 \ub178\ub825\uc73c\ub85c, \ud329\ucee4\ub4dc \uc5b4\ub9b0\uc774 \ubcd1\uc6d0\uc758 \uac04 \uc774\uc2dd \ud300, \ubcd1\ub9ac\ud559\uc790, DNA \ubd84\uc11d\uac00 \ub4f1 \ub9ce\uc740 \uad6c\uc131\uc6d0\uc774 \ucc38\uc5ec\ud569\ub2c8\ub2e4.<\/p>\n<p>\uc138\uc774\uc9c0\ub294 &quot;\uc2e4\uc2dc\uac04 \uc2dc\ud000\uc2f1\uacfc \ubd84\uc11d\uc744 \ucda9\ubd84\ud788 \ube60\ub974\uac8c \uc9c4\ud589\ud558\uc5ec \ud658\uc790\uc5d0\uac8c \uc2e4\uc9c8\uc801\uc778 \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\uae30\ub97c \ubc14\ub78d\ub2c8\ub2e4.&quot;\ub77c\uace0 \ub9d0\ud588\uc2b5\ub2c8\ub2e4. &quot;\ud604\uc7ac \uc774 \uacfc\uc815\uc5d0\ub294 6\uac1c\uc6d4 \uc774\uc0c1\uc774 \uac78\ub9bd\ub2c8\ub2e4. \uc2e4\uc218\ub85c \uc554\uc744 \uc624\uc9c4\ud558\ub294 \uc77c\uc774 \uc788\uc5b4\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4.&quot;<\/p>\n<h2>\uac1c\uc778 \ub9de\ucda4 \uc758\ud559<\/h2>\n<p>\uc774\ub7ec\ud55c \uc720\ud615\uc758 \ud611\ub825 \uc5f0\uad6c\ub294 \uc2a4\ud0e0\ud37c\ub4dc \uc18c\uc544\uc554 \uc0dd\ubb3c\ud559 \ud504\ub85c\uadf8\ub7a8\uc758 \ucc28\ubcc4\uc810\uc785\ub2c8\ub2e4. \ub9b0\ub4dc\ud558\ub974\ud2b8 \uac00\ubb38 \uc18c\uc544\uc554 \uc0dd\ubb3c\ud559 \uad50\uc218\uc778 \ub9c8\uc774\ud074 \ud074\ub9ac\uc5b4\ub9ac \ubc15\uc0ac\uc758 \uc9c0\ud718 \uc544\ub798, \uc138\uc774\uc9c0\uc640 \ub2e4\ub978 \uc5f0\uad6c\uc9c4\uc740 \uac1c\ubcc4 \ud658\uc790\uc5d0 \ub9de\ucd98 \ud45c\uc801 \uce58\ub8cc\ubc95, \uc989 \uac1c\uc778 \ub9de\ucda4 \uc758\ud559\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<h2>\ub9ce\uc740 \ub9c8\uc74c<\/h2>\n<p>\uc774\ub7ec\ud55c \uc5f0\uad6c\uc9c4 \uc911\uc5d0\ub294 \uc18c\uc544\uacfc \uc870\uad50\uc218\uc778 \ub9e4\ud29c \ud3ec\ub974\ud14c\uc6b0\uc2a4 \ubc15\uc0ac\uac00 \uc788\ub294\ub370, \uadf8\ub294 \uc720\uc804\uc790 \uce58\ub8cc\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uc811\uadfc\ubc95\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&quot;\uc804\ud1b5\uc801\uc778 \uc811\uadfc\ubc95\uc740 \uc720\uc804\uc790 \uc870\uc791 \ubc14\uc774\ub7ec\uc2a4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc190\uc0c1\ub41c \uc720\uc804\uc790\uc758 \uac74\uac15\ud55c \ubc84\uc804\uc744 \ud658\uc790\uc758 DNA\uc5d0 \uc8fc\uc785\ud558\ub294 \uac83\uc785\ub2c8\ub2e4.&quot;\ub77c\uace0 \ud3ec\ub974\ud14c\uc6b0\uc2a4\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uc774 \ubc29\ubc95\uc740 \ud2b9\uc815 \uc9c8\ubcd1\uc5d0\ub294 \ud6a8\uacfc\uac00 \uc788\uc9c0\ub9cc, \ubb38\uc81c\ub294 \ubc14\uc774\ub7ec\uc2a4\uac00 \uc720\uc804\uccb4\uc758 \uc5b4\ub290 \uacf3\uc73c\ub85c \uce68\ud22c\ud558\ub294\uc9c0 \ud1b5\uc81c\ud560 \uc218 \uc5c6\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \ub54c\ub85c\ub294 \uc815\uc0c1\uc801\uc778 \uc720\uc804\uc790\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \uc138\ud3ec\uac00 \uc554\uc138\ud3ec\ub85c \ubcc0\ud558\uac8c \ub9cc\ub4e4\uae30\ub3c4 \ud569\ub2c8\ub2e4.&quot;<\/p>\n<p>\ud3ec\ub974\ud14c\uc6b0\uc2a4\ub294 \ubc14\uc774\ub7ec\uc2a4 \ub300\uc2e0 &#039;\uc798\ub77c \ubd99\uc774\uae30&#039; \ubc29\uc2dd\uc758 \uc720\uc804\uc790 \uce58\ub8cc\ub97c \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uccab \ubc88\uc9f8 \ub2e8\uacc4\ub294 \ud658\uc790\ub85c\ubd80\ud130 \uc9c8\ubcd1\uc5d0 \uac78\ub9b0 \uc904\uae30\uc138\ud3ec\ub97c \ucd94\ucd9c\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \ub2e4\uc74c\uc73c\ub85c, \ub3cc\uc5f0\ubcc0\uc774 \uc720\uc804\uc790\ub97c \uc778\uc2dd\ud558\ub294 \ud2b9\uc218 \ub2e8\ubc31\uc9c8\uc744 \uc904\uae30\uc138\ud3ec DNA\uc5d0 \uc8fc\uc785\ud558\uc5ec \uc808\ubc18\uc73c\ub85c \ub098\ub204\uace0, \ub3cc\uc5f0\ubcc0\uc774\ub97c \uad50\uc815\ud55c \ud6c4 \uac74\uac15\ud55c DNA\ub97c \ub2e4\uc2dc \ubd99\uc5ec \ub123\uc2b5\ub2c8\ub2e4. \ud3ec\ub974\ud14c\uc6b0\uc2a4\uc640 \uadf8\uc758 \uc5f0\uad6c\ud300\uc740 \ud604\uc7ac \uacb8\uc0c1 \uc801\ud608\uad6c \ube48\ud608\uc744 \uc720\ubc1c\ud558\ub294 \uc720\uc804\uc790\ub97c \ubcf5\uad6c\ud558\ub294 \ub370 \uc9d1\uc911\ud558\uace0 \uc788\uc9c0\ub9cc, \uc774 \uae30\uc220\uc740 \ub2e4\ub978 \uc720\uc804 \uc9c8\ud658\uc5d0\ub3c4 \uc801\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ucd5c\uadfc \ud3ec\ub974\ud14c\uc6b0\uc2a4\ub294 \ub85c\ub9ac \ud06c\ub77c\uc6b0\uc2a4 \ub77c\ucf65 \uad50\uc218 \uc7a5\ud559\uc0dd(Laurie Kraus Lacob Faculty Scholar)\uc73c\ub85c \uc120\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 5\ub144 \uc7a5\ud559\uae08\uc740 \uadf8\uc758 \uc5f0\uad6c\uc2e4 \uc778\ub825\uacfc \ud504\ub85c\uc81d\ud2b8\ub97c \uc9c0\uc6d0\ud569\ub2c8\ub2e4. &quot;\ub77c\ucf65 \uc7a5\ud559\uae08\uacfc \uac19\uc740 \uae30\ubd80\uae08\uc740 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uc774\ub7f0 \uc885\ub958\uc758 \uc5f0\uad6c\ub294 \ub2e8\uc2dc\uac04\uc5d0 \uc774\ub8e8\uc5b4\uc9c8 \uc218 \uc5c6\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.&quot;\ub77c\uace0 \uadf8\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uc774 \uc7a5\ud559\uae08\uc740 \uc2e4\uc9c8\uc801\uc778 \uc9c4\uc804\uc744 \uc774\ub8e8\ub294 \ub370 \ud544\uc694\ud55c \uc2dc\uac04\uacfc \uc790\uc6d0\uc744 \uc81c\uacf5\ud558\ub294 \uc7a5\uae30\uc801\uc778 \uc9c0\uc6d0\uc785\ub2c8\ub2e4.&quot;<br \/>\n\uc7ac\uac74\ub41c \uba74\uc5ed \uccb4\uacc4<\/p>\n<p>\uc2a4\ud0e0\ud3ec\ub4dc \uacfc\ud559\uc790\ub4e4\uc740 \ub610\ud55c \uc904\uae30\uc138\ud3ec\uc640 \uc131\uc219\uc138\ud3ec\uc758 \uc911\uac04 \ub2e8\uacc4\uc778 \uc804\uad6c\uc138\ud3ec\ub97c \uc774\uc6a9\ud574 \uc18c\uc544\uc554 \uce58\ub8cc\ubc95\uc744 \uac1c\uc120\ud558\ub294 \uc0c8\ub85c\uc6b4 \ubc29\ubc95\uc744 \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ucf00\ub124\uc2a4 \uc640\uc778\ubc84\uadf8 \ubc15\uc0ac\ub294 \ucd5c\uadfc \ubc1c\uacac\ub41c \uace8\uc218 \uc138\ud3ec\uc758 \uc790\uc190\uc778 \uacf5\ud1b5\ud615 \ubaa8\uc138\ud3ec \uc804\uad6c\uc138\ud3ec(CLP)\ub77c\ub294 \uc138\ud3ec \uc720\ud615\uc744 \uc5f0\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. CLP\ub294 \uac10\uc5fc\uacfc \uc2f8\uc6b0\ub294 \ubc31\ud608\uad6c\uc778 \ub9bc\ud504\uad6c\ub97c \uc0dd\uc131\ud558\uba70, \uace8\uc218 \uc774\uc2dd\uc744 \ubc1b\uc740 \uc5b4\ub9b0\uc774\uc758 \uba74\uc5ed\ub825 \uac15\ud654\uc5d0 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ub9ce\uc740 \ubc31\ud608\ubcd1 \ud658\uc790\ub4e4\uc774 \uace8\uc218\ub97c \ud30c\uad34\ud558\uc5ec \uc554\uc138\ud3ec\ub97c \uc8fd\uc774\ub294 \ud56d\uc554 \ud654\ud559\uc694\ubc95\uc5d0 \uc798 \ubc18\uc751\ud569\ub2c8\ub2e4. \uace0\uc6a9\ub7c9\uc758 \ud56d\uc554 \ud654\ud559\uc694\ubc95\uc744 \uacac\ub51c \uc218 \uc5c6\ub294 \uc18c\uc544\ub294 \uba74\uc5ed \uccb4\uacc4 \ud68c\ubcf5\uc744 \uc704\ud574 \uace8\uc218 \uc774\uc2dd\uc744 \ubc1b\uae30\ub3c4 \ud569\ub2c8\ub2e4.<\/p>\n<p>&quot;\ubb38\uc81c\ub294 \uc0c8\ub85c\uc6b4 \uba74\uc5ed \uccb4\uacc4\ub97c \uac15\ud654\ud558\uc5ec \ub354 \ube68\ub9ac \ud68c\ubcf5\uc2dc\ud0a4\uace0 \uc554\uc744 \ub354 \ube68\ub9ac \ud1b5\uc81c\ud560 \uc218 \uc788\ub294 \ubc29\ubc95\uc740 \ubb34\uc5c7\uc778\uac00\uc785\ub2c8\ub2e4.&quot; \uc18c\uc544\uc554 \ubc0f \ud608\uc561 \uc9c8\ud658 \ubd84\uc57c\uc758 \uc564 T. \ubc0f \ub85c\ubc84\ud2b8 M. \ubca0\uc774\uc2a4 \uad50\uc218\uc778 \uc640\uc778\ubc84\uadf8\uac00 \uc9c8\ubb38\ud569\ub2c8\ub2e4.<\/p>\n<p>\uace8\uc218 \uc774\uc2dd \ud6c4 \uc0c8\ub85c\uc6b4 \uba74\uc5ed \uccb4\uacc4\uac00 \ubc1c\ub2ec\ud558\ub294 \ub370\ub294 \uc77c\ubc18\uc801\uc73c\ub85c 6\uac1c\uc6d4\uc5d0\uc11c 1\ub144\uc774 \uac78\ub9bd\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc640\uc778\ubc84\uadf8\uc640 \uadf8\uc758 \ub3d9\ub8cc\ub4e4\uc774 \uc218\ud589\ud55c \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 CLP\uc640 \uc131\uc7a5 \uc778\uc790 \uc778\ud130\ub8e8\ud0a8-7\uc744 \ubcd1\uc6a9\ud558\uba74 \uc774\uc2dd \ud6c4 3~6\uc8fc \ub9cc\uc5d0 \uc0c8\ub85c\uc6b4 \uba74\uc5ed \uccb4\uacc4\ub97c \ud615\uc131\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc640\uc778\ubc84\uadf8 \ubc15\uc0ac\ub294 &quot;\uba74\uc5ed \uccb4\uacc4\uac00 \ub354 \ube68\ub9ac \ubc1c\ub2ec\ud560\uc218\ub85d \ubc31\ud608\ubcd1\uc774 \uc7ac\ubc1c\ud560 \uac00\ub2a5\uc131\uc740 \ub0ae\uc544\uc9c4\ub2e4&quot;\uace0 \uc124\uba85\ud569\ub2c8\ub2e4.<\/p>\n<p>\uc774\uc2dd\uacfc \ud56d\uc554 \ud654\ud559\uc694\ubc95\uc758 \ub610 \ub2e4\ub978 \ubb38\uc81c\ub294 \ud658\uc790\ub4e4\uc774 \uac10\uc5fc \uc704\ud5d8\uc774 \ub192\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \uc800\ud76c \uc5f0\uad6c\uc2e4\uc5d0\uc11c\ub294 CLP\uac00 \uae30\ubcf8\uc801\uc73c\ub85c \uac10\uc5fc\uc744 \uc608\ubc29\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc640\uc778\ubc84\uadf8\uc640 \uadf8\uc758 \ub3d9\ub8cc\ub4e4\uc740 \ub0b4\ub144\uc5d0 \uc554 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c CLP\uc758 \ud6a8\uacfc\ub97c \uc2dc\ud5d8\ud558\ub294 \uc2dc\ubc94 \uc5f0\uad6c\ub97c \uacc4\ud68d\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc740 \ud56d\uc554 \ud654\ud559\uc694\ubc95 \ud6c4 \ubc31\ud608\ubcd1\uc774 \uc7ac\ubc1c\ud55c \uc5b4\ub9b0\uc774 24\uba85\uc744 \ubaa8\uc9d1\ud560 \uacc4\ud68d\uc785\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uc640\uc778\ubc84\uadf8\ub294 \uc784\uc0c1\uc2dc\ud5d8 \ube44\uc6a9\uc774 \ub9e4\uc6b0 \ube44\uc2f8\uba70, \uc804\ud1b5\uc801\uc778 \uc790\uae08 \uc9c0\uc6d0\ucc98\uc778 \ubbf8\uad6d \uad6d\ub9bd\ubcf4\uac74\uc6d0(NIH)\uc758 \uc9c0\uc6d0\uc744 \ubc1b\ub294 \uac83\uc774 \ub9e4\uc6b0 \uacbd\uc7c1\uc774 \uce58\uc5f4\ud574\uc84c\ub2e4\uace0 \ub9d0\ud569\ub2c8\ub2e4.<\/p>\n<p>&quot;\ud328\ucee4\ub4dc\uc5d0\uc11c \uc9c4\ud589\ud558\ub294 \uc784\uc0c1 \uc5f0\uad6c\ub294 \ub3d9\uc885 \uc5f0\uad6c \uc911 \ucd5c\ucd08\uc5d0 \uc18d\ud569\ub2c8\ub2e4.&quot;\ub77c\uace0 \uc640\uc778\ubc84\uadf8\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\ud558\uc9c0\ub9cc NIH \uc790\uae08 \uc9c0\uc6d0\uc5d0\ub9cc \uc758\uc874\ud558\ub358 \uc2dc\ub300\ub294 \uc774\ubbf8 \uc624\ub798\uc804\uc5d0 \uc9c0\ub098\uac14\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc758 \uc9c0\uc18d\uc131\uc744 \uc704\ud574 \uc790\uc120 \ud65c\ub3d9\uc5d0 \uc810\uc810 \ub354 \uc758\uc874\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.&quot;<\/p>\n<h2>\uc544\ud0ac\ub808\uc2a4\uac74\uc744 \ucc3e\uc544\uc11c<\/h2>\n<p>\uc18c\uc544 \uace8\uc554 \uc911 \uac00\uc7a5 \ud754\ud55c \ub450 \uac00\uc9c0 \uc720\ud615\uc778 \uc720\uc789 \uc721\uc885\uacfc \uace8\uc721\uc885\uc740 \uc870\uae30\uc5d0 \ubc1c\uacac \uc2dc \uc0dd\uc874\uc728\uc774 70%\uc5d0 \ub2ec\ud569\ub2c8\ub2e4. \uc548\ud0c0\uae5d\uac8c\ub3c4 \ub9ce\uc740 \uc5b4\ub9b0 \ud658\uc790\ub4e4\uc774 \ud328\ucee4\ub4dc \uc5b4\ub9b0\uc774\ubcd1\uc6d0\uc5d0 \uc9c4\ub2e8\uc744 \ubc1b\uc73c\ub7ec \uc62c \ub54c\ucbe4\uc774\uba74 \uc885\uc591\uc740 \uc774\ubbf8 \uc804\uc774\ub41c \ud6c4\uc785\ub2c8\ub2e4.<\/p>\n<p>&quot;\uc774 \uc544\uc774\ub4e4\uc758 \uc0dd\uc874 \ud655\ub960\uc740 20%\uc5d0 \ubd88\uacfc\ud569\ub2c8\ub2e4.&quot;\ub77c\uace0 \uc18c\uc544\uc554 \uc0dd\ubb3c\ud559 \uc870\uad50\uc218\uc778 \uc54c\ub808\ud55c\ub4dc\ub85c \uc2a4\uc704\ud2b8-\ucf54\ub370\ub85c \ubc15\uc0ac\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uc800\ud76c\ub294 \uc804\uc774\uc131 \uace8\uc885\uc591\uacfc \uadf8\ub807\uc9c0 \uc54a\uc740 \uace8\uc885\uc591\uc758 \ucc28\uc774\ub97c \uc774\ud574\ud558\ub824\uace0 \ub178\ub825\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc885\uc591\uc758 \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uc5d0 \ub300\ud574 \ub354 \ub9ce\uc774 \uc54c\uc218\ub85d, \uadf8 \uc544\ud0ac\ub808\uc2a4\uac74\uc744 \ud30c\uc545\ud558\uace0 \uc774\ub97c \ucc28\ub2e8\ud558\ub294 \uc57d\ubb3c\uc744 \ucc98\ubc29\ud560 \uac00\ub2a5\uc131\uc774 \ub192\uc544\uc9d1\ub2c8\ub2e4.&quot;<\/p>\n<p>\uc720\uc789 \uc721\uc885\uacfc \uace8\uc721\uc885\uc740 \uc544\uc774\uac00 \ud0dc\uc5b4\ub09c \ud6c4 \ubc1c\uc0dd\ud558\ub294 DNA \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc778\ud574 \ubc1c\uc0dd\ud569\ub2c8\ub2e4. &quot;\ud558\uc9c0\ub9cc \uc774 \uc9c8\ubcd1\uc758 \ubd84\uc790\uc801 \uc6d0\uc778\uc740 \uc774\ud574\ud558\uc9c0\ub9cc, \uc65c \uc5b4\ub5a4 \uc0ac\ub78c\uc5d0\uac8c\ub294 \ubc1c\uc0dd\ud558\uace0 \ub2e4\ub978 \uc0ac\ub78c\uc5d0\uac8c\ub294 \ubc1c\uc0dd\ud558\uc9c0 \uc54a\ub294\uc9c0\ub294 \uc544\uc9c1 \ubaa8\ub985\ub2c8\ub2e4.&quot;\ub77c\uace0 \ud0c0\uc2dc\uc544 \ubc0f \uc874 \ubaa8\uadf8\ub9ac\uc9c0 \uc18c\uc544 \uc911\uac1c\uc758\ud559 \uad50\uc218\uc778 \uc2a4\uc704\ud2b8-\ucf54\ub370\ub85c\ub294 \uc124\uba85\ud569\ub2c8\ub2e4.<\/p>\n<p>\uc774 \uc720\uc804\uc801 \uc218\uc218\uaed8\ub07c\ub97c \ud480\uae30 \uc704\ud574 \uc2a4\uc704\ud2b8-\ucf54\ub370\ub85c\ub294 \uc2a4\ud0e0\ud37c\ub4dc\uc758 \uace0\ucc98\ub9ac\ub7c9 DNA \uc2dc\ud000\uc2f1 \uc2dc\uc124\uc744 \ud65c\uc6a9\ud588\uc2b5\ub2c8\ub2e4. &quot;\uc774 \uae30\uc220\uc740 \uc885\uc591 \uc804\uccb4\uc758 \uc2a4\ub0c5\uc0f7\uc744 \ucd2c\uc601\ud558\uc5ec \ubaa8\ub4e0 \uc720\uc804\uc790\uc5d0\uc11c \ubc1c\uc0dd\ud558\ub294 \ubaa8\ub4e0 \ubcc0\ud654\ub97c \ub3d9\uc2dc\uc5d0 \uc0b4\ud3b4\ubcfc \uc218 \uc788\uc2b5\ub2c8\ub2e4.&quot;\ub77c\uace0 \uadf8\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uc774 \uae30\uc220\uc740 \uc885\uc591\uc5d0\uc11c \uc720\uc804\uc801 \uc0ac\uac74\uc744 \ud30c\uc545\ud558\uace0 \uc774\ub97c \uc9c8\ubcd1 \uc9c4\ud589 \ubc29\uc2dd\uc774\ub098 \ud658\uc790\uc758 \uce58\ub8cc \ubc18\uc751\uacfc \uc5f0\uad00\uc2dc\ud0a4\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub429\ub2c8\ub2e4.&quot;<\/p>\n<p>\uc2a4\uc704\ud2b8-\ucf54\ub370\ub85c\ub294 \ub610\ud55c \uc2a4\ud0e0\ud3ec\ub4dc \uc904\uae30\uc138\ud3ec \uc0dd\ubb3c\ud559 \ubc0f \uc7ac\uc0dd \uc758\ud559 \uc5f0\uad6c\uc18c\uc758 \ub3d9\ub8cc\ub4e4\uacfc \ud611\ub825\ud558\uc5ec \uc554\uc744 \uc720\ubc1c\ud558\ub294 \ud2b9\uc815 \uc720\uc804\uc801 \uc0ac\uac74\uc5d0 \ud2b9\ud788 \ucde8\uc57d\ud55c \uc5fc\uc0c9\uccb4\ub97c \uac00\uc9c4 \ud2b9\uc815 \uc138\ud3ec \uc720\ud615\uc774 \uc788\ub294\uc9c0 \ud655\uc778\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&quot;\uadf8 \uc138\ud3ec \uc720\ud615\uc744 \uc2dd\ubcc4\ud560 \uc218 \uc788\ub2e4\uba74 \ub354 \ub098\uc740 \uce58\ub8cc\ubc95 \uac1c\ubc1c\uc758 \uae30\ud68c\uac00 \uc0dd\uae38\uc9c0\ub3c4 \ubaa8\ub985\ub2c8\ub2e4.&quot;\ub77c\uace0 \uadf8\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uc815\ub9d0 \ud765\ubbf8\ub85c\uc6b4 \uc77c\uc785\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uac1c\ubcc4 \ud658\uc790 \uce58\ub8cc \ubc29\uc2dd\uc5d0 \ud601\uba85\uc744 \uc77c\uc73c\ud0a4\ub294 \ub2e8\uacc4\uc5d0 \uc788\uc2b5\ub2c8\ub2e4.&quot;<\/p>\n<h2>100% \uacbd\ud654\ub428<\/h2>\n<p>30\ub144 \uc804 \uce90\uc2ac\ub9b0 \uc0ac\uce74\ubaa8\ud1a0 \ubc15\uc0ac\uac00 \uc758\ub300\uc5d0 \ub2e4\ub2d0 \ub2f9\uc2dc, \uae09\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1(AML)\uc744 \uc553\uace0 \uc788\ub294 \uc5b4\ub9b0\uc774\uc758 \uc608\ud6c4\ub294 \ub9e4\uc6b0 \uc554\uc6b8\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&quot;\ub2f9\uc2dc \uc18c\uc544 AML \ud658\uc790\uc758 \uc0dd\uc874\uc728\uc740 20% \ubbf8\ub9cc\uc774\uc5c8\uc2b5\ub2c8\ub2e4.&quot;\ub77c\uace0 \uc0ac\uce74\ubaa8\ud1a0 \ubc15\uc0ac\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\ud604\uc7ac \uc804\uccb4 \uc0dd\uc874\uc728\uc740 \uc57d 50%\ub85c, \uc5ec\uc804\ud788 \uc6a9\ub0a9\ud560 \uc218 \uc5c6\ub294 \uc218\uc900\uc785\ub2c8\ub2e4. \uc6b0\ub9ac\uc758 \ubaa9\ud45c\ub294 AML \uc18c\uc544 \ud658\uc790\uc758 100%\ub97c \uc644\uce58\ud558\ub294 \uac83\uc785\ub2c8\ub2e4.&quot;<\/p>\n<p>AML \ubc0f \uae30\ud0c0 \ud608\uc561 \uc9c8\ud658 \ubd84\uc57c\uc758 \ub110\ub9ac \uc54c\ub824\uc9c4 \uc804\ubb38\uac00\uc778 \uc0ac\uce74\ubaa8\ud1a0\ub294 \ucd5c\uadfc \uc2a4\ud0e0\ud3ec\ub4dc \ub300\ud559\uc758 \uc18c\uc544 \ud608\uc561\ud559, \uc885\uc591\ud559, \uc904\uae30\uc138\ud3ec \uc774\uc2dd \ubc0f \uc554 \uc0dd\ubb3c\ud559 \ubd80\ubb38\uc758 \ucc45\uc784\uc790\ub85c \uc784\uba85\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ud328\ucee4\ub4dc \uc5b4\ub9b0\uc774\ubcd1\uc6d0\uc5d0\uc11c\ub294 \ub9e4\ub144 \uc57d 10\uba85\uc758 \ud658\uc790\uac00 \uae09\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1(AML)\uc73c\ub85c \uce58\ub8cc\ub97c \ubc1b\uc2b5\ub2c8\ub2e4. \uae09\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1\uc740 \uc131\uc778\uc5d0\uc11c\ub294 \ube44\uad50\uc801 \ud754\ud558\uace0 \uc885\uc885 \uce58\uba85\uc801\uc774\uc9c0\ub9cc \uc18c\uc544\uc5d0\uc11c\ub294 \ub4dc\ubb45\ub2c8\ub2e4. \uae09\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1\uc740 \uace8\uc218\uc5d0\uc11c \ub2e4\ub7c9\uc758 \ube44\uc815\uc0c1\uc801\uc778 \ud608\uc561 \uc138\ud3ec\ub97c \uc0dd\uc131\ud558\uac8c \ud558\ub294\ub370, \uc774\ub7ec\ud55c \ud608\uc561 \uc138\ud3ec\ub294 \ub1cc, \ube44\uc7a5 \ubc0f \uae30\ud0c0 \uc7a5\uae30\ub97c \uce68\ubc94\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>AML\uc758 \uc6d0\uc778\uc740 \uc544\uc9c1 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\uc9c0\ub9cc, \uc0ac\uce74\ubaa8\ud1a0\uc640 \ub3d9\ub8cc\ub4e4\uc740 \uc911\uc694\ud55c \ub2e8\uc11c\ub97c \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. &quot;\uc6b0\ub9ac\ub294 \uc138\ud3ec \ubd84\uc5f4, \uc131\uc219, \ub610\ub294 \ud504\ub85c\uadf8\ub7a8\ub41c \uc138\ud3ec \uc0ac\uba78\uc744 \uc720\ub3c4\ud558\ub294 \uc2e0\ud638\ub97c \uc774\ud574\ud558\uae30 \uc704\ud574 \ub178\ub825\ud574 \uc654\uc2b5\ub2c8\ub2e4.&quot;\ub77c\uace0 \uadf8\ub140\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uc57d 10\ub144 \uc804, \uc6b0\ub9ac\ub294 CREB\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc744 \ubc1c\uacac\ud588\ub294\ub370, \uc774 \ub2e8\ubc31\uc9c8\uc740 AML \ud658\uc790\uc758 \uace8\uc218 \uc138\ud3ec\uc5d0\uc11c \uacfc\ub2e4 \uc0dd\uc131\ub418\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. 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