{"id":3884,"date":"2017-05-03T21:28:03","date_gmt":"2017-05-03T21:28:03","guid":{"rendered":"https:\/\/lpfch.org\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/"},"modified":"2024-02-19T18:00:17","modified_gmt":"2024-02-19T18:00:17","slug":"unleashing-cancer-immunotherapy-against-a-diabolical-disease","status":"publish","type":"post","link":"https:\/\/lpfch.org\/ko\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/","title":{"rendered":"\uc545\ub9c8\uc758 \uc9c8\ubcd1\uc5d0 \ub9de\uc11c \uc554 \uba74\uc5ed \uc694\ubc95\uc744 \ud3bc\uce58\ub2e4"},"content":{"rendered":"

\uc2a4\ud0e0\ud37c\ub4dc \uc554 \uc5f0\uad6c\uc18c \ubd80\uc18c\uc7a5\uc774\uc790 \uc2a4\ud0e0\ud37c\ub4dc \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uc18c\uc544\uacfc(\ud608\uc561\ud559\/\uc885\uc591\ud559) \ubc0f \ub0b4\uacfc \uad50\uc218\uc778 \ud06c\ub9ac\uc2a4\ud0c8 \ub9e5\uceec \ubc15\uc0ac\ub294 \ucd08\ub4f1\ud559\uad50 6\ud559\ub144 \ub54c \ucc98\uc74c\uc73c\ub85c \uc758\uc0ac\uac00 \ub418\uace0 \uc2f6\ub2e4\ub294 \uafc8\uc744 \uafb8\uc5c8\uc2b5\ub2c8\ub2e4. \ub9e5\uceec \ubc15\uc0ac\ub294 "\uc800\uc5d0\uac8c \ud070 \uc601\uac10\uc744 \uc8fc\uc168\ub358 \uc5ec\uc131 \uacfc\ud559 \uc120\uc0dd\ub2d8\uc774 \uacc4\uc168\uc5b4\uc694."\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4. "\ud574\ubd80\ud559\uacfc \uc0dd\ub9ac\ud559\uc5d0 \ub300\ud55c \uacf5\ubd80\ub97c \ub9ce\uc774 \ud588\ub294\ub370, \uc138\uc0c1\uc5d0\uc11c \uac00\uc7a5 \uba4b\uc9c4 \ubd84\uc57c\ub77c\uace0 \uc0dd\uac01\ud588\uc5b4\uc694."<\/p>\n

\uc2a4\ud0e0\ud37c\ub4dc \uc138\ud3ec \ubc0f \uc720\uc804\uc790 \uc758\ud559 \uc5f0\uad6c\uc18c\uc758 \uc758\ub8cc \uacf5\ub3d9 \ucc45\uc784\uc790\uc774\uae30\ub3c4 \ud55c \ub9e5\uceec\uc740 \uc218\ub828 \uae30\uac04 \ub3d9\uc548 \ubaa9\ud45c\ub97c \ub2e4\ub4ec\uc5b4 \ub098\uac00\ub294 \ub3d9\uc548\uc5d0\ub3c4 \uc790\uc2e0\uc758 \uafc8\uc5d0 \ucda9\uc2e4\ud588\uc2b5\ub2c8\ub2e4. \ub9e5\uceec\uc740 "\uc2ec\uc7a5\uc678\uacfc \uc758\uc0ac\uac00 \ub418\uace0 \uc2f6\ub2e4\uace0 \uc0dd\uac01\ud588\uc5b4\uc694."\ub77c\uace0 \ub9d0\ud558\uba70, "\ud558\uc9c0\ub9cc \uc190\uc7ac\uc8fc\uac00 \ubcc4\ub85c \uc5c6\uc5c8\uace0, \uc218\uc220\uc2e4\uc5d0 \ub4e4\uc5b4\uac08 \ub54c\ub9c8\ub2e4 \ucf54\uac00 \ud56d\uc0c1 \uac00\ub824\uc6e0\uc5b4\uc694."\ub77c\uace0 \ub367\ubd99\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n

\uc5bc\ub9c8 \uc9c0\ub098\uc9c0 \uc54a\uc544 \uadf8\ub140\ub294 \uc790\uc2e0\uc5d0\uac8c \ub531 \ub9de\ub294 \ubd84\uc57c\ub97c \ucc3e\uc558\uc2b5\ub2c8\ub2e4. \ubc14\ub85c \uc18c\uc544\uc554 \uc804\ubb38\uc758\uc600\uc2b5\ub2c8\ub2e4. "\uc774\uacf3\uc5d0 \uc81c \uc5d0\ub108\uc9c0\ub97c \uc3df\uace0 \uc2f6\ub2e4\ub294 \uc0dd\uac01\uc774 \ub4e4\uc5c8\uc5b4\uc694. \uc774 \uc138\uc0c1\uc5d0\uc11c \uc544\uc774\ub4e4\uc758 \uc554\uacfc \uc2f8\uc6b0\ub294 \uac83\ubcf4\ub2e4 \ub354 \uc88b\uc740 \uc2f8\uc6c0\uc740 \uc5c6\uc73c\ub2c8\uae4c\uc694."<\/p>\n

\uadf8 \uc774\ud6c4\ub85c \ub9e5\uceec\uc758 \uc5f0\uad6c\ub294 \uc804\ud22c\uc758 \uc804\uc120\uc744 \uc815\uc758\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. 1984\ub144, \uadf8\ub140\ub294 \uc554 \uba74\uc5ed \uc694\ubc95\uc5d0 \ub300\ud55c \ucd08\uae30 \ub17c\ubb38\uc744 \uc77d\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uc694\ubc95\uc740 \uc2e0\uccb4\uc758 \uba74\uc5ed \uccb4\uacc4\ub97c \uc774\uc6a9\ud558\uc5ec \uc554\uc138\ud3ec\uc5d0 \ub300\ud56d\ud558\ub294 \uc811\uadfc\ubc95\uc785\ub2c8\ub2e4. "\uc544\ubb34\ub3c4 \uadf8\uac83\uc774 \uc815\ub9d0 \ud6a8\uacfc\uac00 \uc788\uc744 \uac70\ub77c\uace0 \uc0dd\uac01\ud558\uc9c0 \ubabb\ud588\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ub9e5\uceec\uc740 \ub9d0\ud569\ub2c8\ub2e4. \uadf8\ub140\ub294 "\uc6b0\ub9ac\uac00 \uc885\uc591\ud559\uc5d0\uc11c \uc77c\uc885\uc758 \ubcc0\ub450\ub9ac\uc600\uc8e0. \uc0ac\ub78c\ub4e4\uc740 \uc6b0\ub9ac\uac00 \uc880 '\ub0af\uc120' \uc874\uc7ac\ub77c\uace0 \uc0dd\uac01\ud588\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ub9d0\ud558\uba70, \ucd08\ucc3d\uae30\ub97c \uc544\uc9c1\ub3c4 \uc0dd\uc0dd\ud558\uac8c \uae30\uc5b5\ud569\ub2c8\ub2e4.<\/p>\n

\ubcfc\ub4dc \uba58\ud1a0\ub9c1<\/h3>\n

1989\ub144, \uadf8\ub140\ub294 \ud544\ub9bd \ud53c\uc870 \ubc15\uc0ac\uc758 \uc9c0\ub3c4 \uc544\ub798 \uad6d\ub9bd\ubcf4\uac74\uc6d0\uc5d0\uc11c \uc554\uc758 \uba74\uc5ed \uccb4\uacc4\ub97c \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4. \ud53c\uc870 \ubc15\uc0ac\ub294 \uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c \uc18c\uc544\uacfc\uc7a5\uc774\uc5c8\uace0, \ub098\uc911\uc5d0 2001\ub144\ubd80\ud130 2012\ub144\uae4c\uc9c0 \uc2a4\ud0e0\ud3ec\ub4dc \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \ud559\uc7a5\uc744 \uc5ed\uc784\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n

"\ud06c\ub9ac\uc2a4\ud138\uc740 \ucd08\ucc3d\uae30\ubd80\ud130 \uba74\uc5ed\ud559\uacfc \uba74\uc5ed\uce58\ub8cc\uc758 \uac00\ub2a5\uc131\uc5d0 \ud5cc\uc2e0\ud588\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ud53c\uc870\ub294 \ud68c\uc0c1\ud569\ub2c8\ub2e4. "\uc800\ub294 \uadf8 \uc810\uc5d0 \uc815\ub9d0 \uac10\uba85\uc744 \ubc1b\uc558\uace0, \uadf8\ub140\uac00 \uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c\uc5d0\uc11c \uc790\uc2e0\uc758 \ube44\uc804\uc744 \ucd94\uad6c\ud558\uba70 \uc131\uc7a5\ud574 \uacb0\uad6d \uc81c\uac00 \ud55c\ub54c \ub9e1\uc558\ub358 \ub9ac\ub354\uc2ed \uc790\ub9ac\ub97c \ucc28\uc9c0\ud558\ub294 \ubaa8\uc2b5\uc744 \uc9c0\ucf1c\ubcf4\uba70 \ubfcc\ub4ef\ud568\uc744 \ub290\uaf08\uc2b5\ub2c8\ub2e4."<\/p>\n

\ub9e5\uce7c\uc740 "\ud544 \ud53c\uc870\ub294 \uc800\uc5d0\uac8c \ubb34\uc11c\uc6b4 \uc9c8\ubcd1\uc744 \uc553\uace0 \uc788\ub294 \uc5b4\ub9b0\uc774\ub97c \ub300\uc0c1\uc73c\ub85c \uc784\uc0c1 \uc5f0\uad6c\ub97c \ud558\ub294 \ub370 \uc788\uc5b4\uc11c \ub300\ub2f4\ud568\uc744 \ubcf4\uc5ec\uc8fc\uace0, \uc5b4\ub9b0\uc774\ub97c \uc704\ud55c \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \ub370 \uc788\uc5b4\uc11c\ub3c4 \ub300\ub2f4\ud568\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \ub300\ub2f4\ud568\uc740 \ub9e5\uce7c\uc774 20\ub144 \ub118\uac8c \ub048\uae30 \uc788\uac8c \ub178\ub825\ud558\ub294 \ub370 \uc6d0\ub3d9\ub825\uc774 \ub418\uc5c8\uace0, \uadf8\ub140\uc640 \ub3d9\ub8cc\ub4e4\uc740 \uba74\uc5ed\uc694\ubc95\uc758 \ube44\ubc00\uc744 \uc810\ucc28 \ubc1d\ud600\ub0c8\uc2b5\ub2c8\ub2e4. \ucd08\uae30 \uc811\uadfc\ubc95\uc740 \ud6a8\uacfc\ub97c \ubcf4\uc774\uae30 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4. \ub9e5\uce7c\uc740 "\ub2e4\ub978 \ubaa8\ub4e0 \uce58\ub8cc\ubc95\uc5d0 \ub0b4\uc131\uc744 \ubcf4\uc600\ub358 \uc554\ub3c4 \uba74\uc5ed\uc694\ubc95\uc73c\ub85c \uc870\uc808\ud558\uace0 \uc644\ud654\ud560 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4.<\/p>\n

\uadf8\ub7ec\ub2e4 2010\ub144, \ub9e5\uce7c\uc758 \uc9c0\ud718 \uc544\ub798 \uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c\uac00 \uc2e0\uccb4\uc758 \uc790\uccb4 \uba74\uc5ed \ubc18\uc751\uc744 \ud65c\uc131\ud654\ud558\ub294 \ud45c\uc801 \uc811\uadfc\ubc95\uc73c\ub85c \ucd5c\ucd08\uc758 \uc784\uc0c1\uc801 \uc131\uacf5 \uc0ac\ub840 \uc911 \ud558\ub098\ub97c \ubcf4\uace0\ud558\uba74\uc11c "\ubaa8\ub4e0 \uac83\uc774 \ubc14\ub00c\uc5c8\uc2b5\ub2c8\ub2e4." \ub9e5\uce7c\uc740 "\ubaa8\ub4e0 \uac83\uc774 \ud3ed\ubc1c\uc801\uc73c\ub85c \ubc1c\uc804\ud588\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ub367\ubd99\uc600\uc2b5\ub2c8\ub2e4. "\uc774\uc81c \uc554 \uce58\ub8cc \ubd84\uc57c\uc5d0\uc11c \uac00\uc7a5 \ud070 \ubc1c\uc804\uc785\ub2c8\ub2e4."<\/p>\n

\uc9c0\ub09c 40\ub144 \ub3d9\uc548 \uc18c\uc544\uc554 \uce58\ub8cc\uc640 \uc0dd\uc874\uc728\uc5d0 \ub9ce\uc740 \uc9c4\uc804\uc774 \uc788\uc5c8\uc74c\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, \uc554 \uba74\uc5ed\uce58\ub8cc\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub294 \uc5ec\uc804\ud788 \uc808\uc2e4\ud788 \ud544\uc694\ud569\ub2c8\ub2e4. \ud654\ud559\uc694\ubc95, \ubc29\uc0ac\uc120\uc694\ubc95, \uc904\uae30\uc138\ud3ec \uc774\uc2dd\uacfc \uac19\uc740 \uce58\ub8cc\ubc95 \ub355\ubd84\uc5d0 \uc18c\uc544\uc554 \ud658\uc790\uc758 5\ub144 \uc0dd\uc874\uc728\uc740 \ud55c\ub54c 10%\uc5d0 \ubd88\uacfc\ud588\uc9c0\ub9cc, \uc774\uc81c\ub294 85%\ub97c \ub118\uc5b4\uc130\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud76c\uadc0\uc554\uc758 \uc0dd\uc874\uc728\uc740 \ud6e8\uc52c \ub0ae\uc73c\uba70, \ud45c\uc900 \uce58\ub8cc\ub294 \uc2dc\uac04\uc774 \uc624\ub798 \uac78\ub9ac\uace0 \ub54c\ub85c\ub294 \uc218\ub144\uc774 \uac78\ub9ac\uba70 \uc2ec\uac01\ud55c \ubd80\uc791\uc6a9\uc744 \ub3d9\ubc18\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. ("\uc6d0\ub354\uac78\uc5d0\uac8c\ub3c4 \uc601\uc6c5\uc774 \ud544\uc694\ud558\ub2e4<\/a>.\u201d) \uadf8\ub9ac\uace0 \uae30\uc874 \uce58\ub8cc\ubc95\uc774 \ud6a8\uacfc\uac00 \uc5c6\uac70\ub098 \uc5ec\ub7ec \ubc88 \uc7ac\ubc1c\ud558\uc5ec \uce58\ub8cc\uc5d0 \ub300\ud55c \ubc18\uc751\uc774 \ub0ae\uc544\uc9c0\ub294 \uc5b4\ub9b0\uc774\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n

"\uc554\uc740 \uc545\ub9c8\uc801\uc785\ub2c8\ub2e4."\ub77c\uace0 \ub9e5\uceec\uc740 \ub9d0\ud55c\ub2e4. "\uc554\uc740 \uc801\uc751\ub825\uc774 \ub6f0\uc5b4\ub098\uace0, \uacc4\uc18d\ud574\uc11c \uc7ac\ubc1c\ud560 \ubc29\ubc95\uc744 \ucc3e\uc544\ub0c5\ub2c8\ub2e4. \uc6b0\ub9ac\ub294 \uc554\uc744 \uc774\uaca8\ub0b4\uc57c \ud569\ub2c8\ub2e4."<\/p>\n

\ud0c0\uac9f\ud654\ub41c \uc811\uadfc \ubc29\uc2dd<\/h3>\n

\uc554\uc744 \uadf9\ubcf5\ud558\ub294 \uadf8\ub140\uc758 \uc9c4\uc804\uc758 \ud575\uc2ec \uc911 \ud558\ub098\ub294 \uc18c\uc544 \uc885\uc591\uacfc \uc131\uc778 \uc885\uc591\uc758 \ucc28\uc774\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \uba74\uc5ed \uc138\ud3ec\ub294 \uc774\uc0c1\uc744 \ucc3e\uc544\ub0b4\ub294\ub370, \uc131\uc778 \uc554\uc5d0\uc11c\ub294 \ub3cc\uc5f0\ubcc0\uc774\uac00 \ub9e4\uc6b0 \ub9ce\uc544 \uc774\ub7ec\ud55c \uc774\uc0c1\uc744 \uc27d\uac8c \ubc1c\uacac\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub9e5\uce98\uc740 \uc18c\uc544 \uc885\uc591\uc740 \uc774\uc0c1\uc774 \uc801\uae30 \ub54c\ubb38\uc5d0 "\ubbf8\uc131\uc219 \uc138\ud3ec\ucc98\ub7fc \ubcf4\uc774\uae30 \ub54c\ubb38\uc5d0 \uba74\uc5ed \uccb4\uacc4\uac00 \uc774\ub97c \uc54c\uc544\ucc28\ub9ac\uc9c0 \ubabb\ud569\ub2c8\ub2e4."\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4. \uc9c1\uad00\uc5d0 \uc5b4\uae0b\ub098 \ubcf4\uc77c \uc218 \uc788\uc9c0\ub9cc, \uc18c\uc544 \uc885\uc591\uc758 \uc0c1\ub300\uc801\uc778 \uacb0\ud568\uc774 \uc18c\uc544 \uc885\uc591\uacfc\uc758 \uc2f8\uc6c0\uc744 \ub354\uc6b1 \uc5b4\ub835\uac8c \ub9cc\ub4dc\ub294 \uc694\uc778\uc774\uae30\ub3c4 \ud569\ub2c8\ub2e4.<\/p>\n

\ub9e5\uce98\uc740 \ubc31\ud608\ubcd1\uacfc \uac19\uc740 \ud2b9\uc815 \uc720\ud615\uc758 \uc885\uc591\uc5d0\uc11c \ubc1c\uacac\ub418\ub294 \uc138\ud3ec\ub97c \ud45c\uc801\uc73c\ub85c \uc0bc\ub294 \uc811\uadfc\ubc95\uc758 \uac00\ub2a5\uc131\uc5d0 \uc9d1\uc911\ud574 \uc654\uc2b5\ub2c8\ub2e4. \uadf8\ub140\ub294 \ud569\uc131\uc0dd\ubb3c\ud559\uc774\ub77c\uace0 \ubd80\ub974\ub294 \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uc5ec "\uc6b0\ub9ac\ub294 \uc0c8\ub85c\uc6b4 \uac83\uc744 \ucc3d\uc870\ud569\ub2c8\ub2e4. \uba74\uc5ed \uccb4\uacc4\ub97c \uc7a5\uc545\ud558\ub294 \uac83\uc774\uc8e0."\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4. "\ub9c8\uce58 \uc0ac\ub0e5\uac1c\uc640 \uac19\uc2b5\ub2c8\ub2e4. \ub0c4\uc0c8\ub97c \ub9e1\uace0 '\uc774\uac78 \uc7a1\uc544\ub77c'\ub77c\uace0 \ub9d0\ud558\ub294 \uac70\uc8e0." \uc18c\uc544\uc554\uc758 \uacbd\uc6b0, \uba74\uc5ed \uccb4\uacc4\ub97c \uc774\uc0c1\uc774\ub098 \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc720\ub3c4\ud558\ub294 \uac83\ub9cc\uc73c\ub85c\ub294 \ucda9\ubd84\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc774\uc0c1\uc774\ub098 \ub3cc\uc5f0\ubcc0\uc774\uc758 \uc218\uac00 \ucda9\ubd84\ud558\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. "\uc6b0\ub9ac\ub294 \uc2e4\uc81c\ub85c \uc138\ud3ec\ub97c \uc885\uc591\uc73c\ub85c \uc720\ub3c4\ud574\uc57c \ud569\ub2c8\ub2e4."<\/p>\n

T \uc138\ud3ec, \uc989 "\ube14\ub7ec\ub4dc\ud558\uc6b4\ub4dc"\ub294 \ud658\uc790\uc5d0\uac8c\uc11c \ucd94\ucd9c\ub418\uc5b4 \ub9e5\uce98\uc758 \ube44\uc720\uc5d0\uc11c "\ub0c4\uc0c8"\ub85c \ubd88\ub9ac\ub294 \ud0a4\uba54\ub77c \ud56d\uc6d0 \uc218\uc6a9\uccb4(CAR)\ub97c \ubc1c\ud604\ud558\ub3c4\ub85d \uc870\uc791\ub41c \ud6c4, \ud658\uc790\uc758 \ud608\ub958\ub85c \ub2e4\uc2dc \uc720\uc785\ub418\uc5b4 \ud45c\uc801 \uba74\uc5ed \uce58\ub8cc \ubc18\uc751\uc744 \uc2dc\uc791\ud569\ub2c8\ub2e4. CAR\uc740 T \uc138\ud3ec\ub97c \uae09\uc131 \ub9bc\ud504\ubaa8\uad6c \ubc31\ud608\ubcd1(ALL)\uc758 CD19\uc640 \uac19\uc740 \ud2b9\uc815 \uc885\uc591 \uc138\ud3ec\ub85c \uc720\ub3c4\ud569\ub2c8\ub2e4. \ud65c\uc131 \uc6a9\ub7c9 \ubc94\uc704\uc758 CD19-CAR \uba74\uc5ed \uc694\ubc95\uc73c\ub85c \uce58\ub8cc\ud588\uc744 \ub54c, \uc774\uc804\uc5d0 \uc7ac\ubc1c\ud588\uac70\ub098 \ub2e4\ub978 \uce58\ub8cc \uc635\uc158\uc774 \uc5c6\uc5c8\ub358 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \ucc38\uc5ec\ud55c ALL \uc18c\uc544 \ud658\uc790\ub4e4\uc740 \uc774\ubbf8 80%\uc758 \ubc18\uc751\ub960\uc744 \ubcf4\uc774\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc774 \uce58\ub8cc\ubc95\uc740 \ud45c\uc900 \uce58\ub8cc\ubc95\ubcf4\ub2e4 \uce58\ub8cc \uae30\uac04\uc774 \uc9e7\uc73c\uba70, \uc7a5\uae30\uc801\uc778 \ubd80\uc791\uc6a9\ub3c4 \uc801\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ud569\ub2c8\ub2e4. \ub9e5\uce98\uc740 \uac00\uae4c\uc6b4 \uc2dc\uc77c \ub0b4\uc5d0 FDA\uc758 CD19-CAR \uc2b9\uc778\uc744 \uae30\ub300\ud569\ub2c8\ub2e4.<\/p>\n

CD19-CAR\uc758 \uac15\ub825\ud55c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c, \ub9e5\uce7c\uacfc \uadf8\ub140\uc758 \ud300\uc740 \ub450 \ubc88\uc9f8 \ud45c\uc801\uc778 CD22\ub97c \uc5f0\uad6c\ud588\uc2b5\ub2c8\ub2e4. CD22\uc5d0 \ub300\ud55c \uc784\uc0c1\uc2dc\ud5d8\uc740 2015\ub144\uc5d0 \uc2dc\uc791\ub418\uc5c8\uc73c\uba70, \ub9e5\uce7c\uc740 \uace7 \uacb0\uacfc\ub97c \ubc1c\ud45c\ud560 \uc608\uc815\uc785\ub2c8\ub2e4. \uc774\uc81c \ub450 \ubc88\uc9f8 \ud45c\uc801\uc744 \ud655\ubcf4\ud568\uc73c\ub85c\uc368 \uc758\uc0ac\ub4e4\uc740 \uac01 \ud45c\uc801\uc744 \uc21c\ucc28\uc801\uc73c\ub85c \uc2dc\ub3c4\ud558\ub294 \uac83 \uc678\uc5d0\ub3c4 \ub450 \ud45c\uc801\uc744 \ub3d9\uc2dc\uc5d0 \uacf5\uaca9\ud560 \uc218 \uc788\ub294 \uae30\ud68c\ub97c \uc5bb\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub9e5\uce7c\uc740 "\ud55c \ubc88\uc5d0 \ud55c \ub2e8\uacc4\uc529 \uc2dc\ub3c4\ud558\ub294 \uac83\uc740 \uc885\uc591\uc774 \uc801\uc751\ud560 \uc2dc\uac04\uc744 \ub108\ubb34 \ub9ce\uc774 \uc8fc\ub294 \uac83 \uac19\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ub9d0\ud558\uba70, "\uadf8\ub798\uc11c \uc774\uc81c \ucd5c\ucd08\uc758 \uc774\uc911 CAR\uc744 \uac1c\ubc1c\ud558\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ub367\ubd99\uc600\uc2b5\ub2c8\ub2e4. CD19\uc640 CD22\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uc774\uc911 CAR\uc758 \uccab \ubc88\uc9f8 \uc778\uccb4 \uc784\uc0c1\uc2dc\ud5d8\uc740 \uba87 \ub2ec \uc548\uc5d0 \uc2a4\ud0e0\ud37c\ub4dc\uc640 \ubbf8\uad6d \uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c\uc5d0\uc11c \uc2dc\uc791\ub420 \uc608\uc815\uc785\ub2c8\ub2e4.<\/p>\n

\ub9e5\uce7c\uc740 \uba74\uc5ed \uc694\ubc95\uc758 \ubc1c\uc804\uc744 \ucd09\uc9c4\ud558\ub294 \uac83 \uc678\uc5d0\ub3c4, \ub9e4\uc6b0 \ub4dc\ubb3c\uc9c0\ub9cc \uc2e0\uacbd \ub3c5\uc131\uc744 \ud3ec\ud568\ud560 \uc218 \uc788\ub294 \ubd80\uc791\uc6a9\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uacc4\uc18d\ud560 \uac83\uc744 \uacb0\uc2ec\ud588\uc2b5\ub2c8\ub2e4. "\uba74\uc5ed \uccb4\uacc4\ub97c \ud65c\uc131\ud654\ud558\uba74 \uc554\uacfc \uc2f8\uc6b0\uae30 \uc704\ud574 \ub9e4\uc6b0 \uac15\ub825\ud558\uac8c \ud65c\uc131\ud654\ud574\uc57c \ud558\ub294\ub370, \uc774\ub294 \ub54c\ub85c\ub294 \uc2ec\uac01\ud55c \ubd80\uc791\uc6a9\uc744 \ucd08\ub798\ud560 \uc218 \uc788\uc73c\uba70, \ub54c\ub85c\ub294 \uc0dd\uba85\uc744 \uc704\ud611\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4."\ub77c\uace0 \ub9e5\uce7c\uc740 \ub9d0\ud569\ub2c8\ub2e4. "\uc6b0\ub9ac\ub294 \ub354 \ub098\uc740 \uc554 \uce58\ub8cc\ubc95\uc744 \ubc1c\uacac\ud558\uace0, \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\uace0, \uc784\uc0c1\uc5d0 \uc801\uc6a9\ud558\uae30 \uc704\ud574 \ub178\ub825\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c, \ub3c5\uc131\uc5d0 \ub300\ud574 \uc5f0\uad6c\ud558\uace0 \uce58\ub8cc\ub97c \ub354 \uc548\uc804\ud558\uac8c \ub9cc\ub4e4\uae30 \uc704\ud574 \ub178\ub825\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4."<\/p>\n

\uc5f0\uad6c \uac00\uc18d\ud654<\/h3>\n

\uc18c\uc544 \uc554 \uba74\uc5ed\uc694\ubc95 \uc5f0\uad6c\ub97c \uc870\uae30\uc5d0 \uc0c1\ub2f9\ud55c \ud22c\uc790\ub85c \uc9c0\uc6d0\ud558\uae30 \uc2dc\uc791\ud55c \ub450 \ub2e8\uccb4\ub294 Stand Up 2 Cancer\uc640 St. Baldrick's Foundation\uc785\ub2c8\ub2e4. \ub450 \ub2e8\uccb4\ub294 2013\ub144\ubd80\ud130 \ub9e5\uce7c\uc774 \uacf5\ub3d9\uc73c\ub85c \uc774\ub044\ub294 8\uac1c \uae30\uad00\uc73c\ub85c \uad6c\uc131\ub41c \uc18c\uc544\uc554 \ub4dc\ub9bc\ud300(Pediatric Cancer Dream Team)\uc5d0 \uc790\uae08\uc744 \uc9c0\uc6d0\ud558\uae30 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4. \ub8e8\uc2e4 \ud328\ucee4\ub4dc \uc18c\uc544\ubcd1\uc6d0 \uc2a4\ud0e0\ud37c\ub4dc\ub294 \ub9e5\uce7c\uc774 \uc2a4\ud0e0\ud37c\ub4dc \ub300\ud559\uad50 \uc758\uacfc\ub300\ud559 \uad50\uc218\uc9c4\uc5d0 \ud569\ub958\ud55c 2016\ub144 1\uc6d4 \uc18c\uc544\uc554 \ub4dc\ub9bc\ud300\uc5d0 \ud569\ub958\ud588\uc2b5\ub2c8\ub2e4. \uc790\uc120\uac00\uc774\uc790 \uae30\uc5c5\uac00\uc778 \uc158 \ud30c\ucee4\uac00 \uc774\ub044\ub294 \uc0c8\ub85c\uc6b4 \ud30c\ucee4 \uc554 \uba74\uc5ed\uc694\ubc95 \uc5f0\uad6c\uc18c(Parker Institute for Cancer Immunotherapy) \ub610\ud55c \uc778\ud504\ub77c\uc640 \uc5f0\uad6c\ub97c \uc9c0\uc6d0\ud569\ub2c8\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \uc790\uae08 \uc9c0\uc6d0\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, \uc18c\uc544\uc554\uc740 \uc5ec\uc804\ud788 \ub9c9\ub300\ud55c \uc9c0\uc6d0 \uae30\ud68c\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \ub9e5\uce7c\uc740 "\uc554\uc740 \ud558\ub098\uc758 \uc9c8\ubcd1\uc774 \uc544\ub2d9\ub2c8\ub2e4."\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4. "\uc5ec\ub7ec \uc9c8\ubcd1\uc774 \ubcf5\ud569\uc801\uc73c\ub85c \uc791\uc6a9\ud569\ub2c8\ub2e4. \uac01 \uc9c8\ubcd1\ub9c8\ub2e4 \ud45c\uc801\uc774 \ub2e4\ub974\uace0, \uc774\ub97c \uac1c\ubc1c\ud558\uae30 \uc704\ud574 \uac01\uae30 \ub2e4\ub978 \uc5f0\uad6c\uc9c4\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc9c8\ubcd1\uc744 \uc81c\ub300\ub85c \uc774\ud574\ud558\uc9c0 \ubabb\ud558\uba74 \uc9c8\ubcd1\uc744 \ud45c\uc801\uc73c\ub85c \uc0bc\uc744 \uc218 \uc5c6\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. \ubc14\ub85c \uc774\uac83\uc774 \uc774 \uc0c8\ub85c\uc6b4 CAR \uc811\uadfc\ubc95\uc758 \uc7a5\uc810\uc785\ub2c8\ub2e4. \uace0\ud615\uc554\uc774\ub098 \ud608\uc561\uc554 \uce58\ub8cc\uc5d0\ub3c4 \uc801\uc6a9 \uac00\ub2a5\ud558\uba70, \ub2e4\ub978 \uce58\ub8cc\ubc95\uacfc \ubcd1\ud589\ud558\uc5ec \uc0ac\uc6a9\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4."<\/p>\n

\ub9e5\uce7c\uc740 "\uc6b0\ub9ac\uac00 \ub2e4\uc74c\uc5d0 \ub2e4\ub8f0 \uc218 \uc788\ub294 \uae30\ud68c\ub294 \ubb34\uad81\ubb34\uc9c4\ud569\ub2c8\ub2e4."\ub77c\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

"\ud558\uc9c0\ub9cc \uc9c0\uae08 \ub2f9\uc7a5\uc740 \uc790\uc6d0\uc5d0 \ub530\ub77c \uc120\ud0dd\ud574\uc57c \ud569\ub2c8\ub2e4. \ub354 \ub9ce\uc740 \uc608\uc0b0\uc774 \uc788\uc73c\uba74 \ub354 \ub9ce\uc740 \uc554\uc744 \ub3d9\uc2dc\uc5d0 \uce58\ub8cc\ud560 \uc218 \uc788\uc744 \uac81\ub2c8\ub2e4."<\/p>\n

\ub9e5\uceec\uc774 \uc774 \uc5f0\uad6c\ub97c \uc8fc\ub3c4\ud568\uc5d0 \ub530\ub77c, \uc2a4\ud0e0\ud37c\ub4dc\ub294 \uc18c\uc544 \uc885\uc591\ud559 \ubd84\uc57c\ub97c \uc0c8\ub85c\uc6b4 \ubc1c\uacac\uacfc \uce58\ub8cc\uc758 \uc601\uc5ed\uc73c\ub85c \uc774\ub04c\uc5b4 \uc18c\uc544\uc554\uc5d0 \ub300\ud55c \uc774\ud574\ubfd0 \uc544\ub2c8\ub77c \uc774\ub97c \uadfc\uc808\ud558\uae30 \uc704\ud55c \ub178\ub825\uae4c\uc9c0 \uc7ac\uc815\uc758\ud558\ub294 \ub370 \uae30\uc5ec\ud560 \uac83\uc785\ub2c8\ub2e4. \uacfc\ud559 \uc218\uc5c5\uc744 \uc990\uae30\ub358 6\ud559\ub144 \uc5ec\ud559\uc0dd\uc774 \uc774 \uc5f0\uad6c\ub97c \ud1b5\ud574 \ubcf4\uc5ec\uc900 \uace0\ubb34\uc801\uc778 \uc131\uacfc\uc785\ub2c8\ub2e4.<\/p>\n

\uc774 \uae30\uc0ac\ub294 2017\ub144 \ubd04\ud638\uc5d0 \ucc98\uc74c \uac8c\uc7ac\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub8e8\uc2e4 \ud328\ucee4\ub4dc \uc5b4\ub9b0\uc774 \ub274\uc2a4<\/a>.<\/em><\/p>\n

\ub4e3\uae30: Crystal Mackall\uc774 \uc218\uc2ed \ub144 \ub3d9\uc548 \uc554\uc5d0 \uac00\uc7a5 \ud070 \ud0c0\uaca9\uc744 \uc900 \uac83\uc5d0 \ub300\ud574 \ub17c\uc758\ud569\ub2c8\ub2e4. supportLPCH.org\/fight<\/a>.<\/strong><\/p>","protected":false},"excerpt":{"rendered":"

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