{"id":4351,"date":"2023-08-22T20:50:34","date_gmt":"2023-08-22T20:50:34","guid":{"rendered":"https:\/\/lpfch.org\/from-loss-comes-hope\/"},"modified":"2025-05-28T21:42:33","modified_gmt":"2025-05-28T21:42:33","slug":"from-loss-comes-hope","status":"publish","type":"post","link":"https:\/\/lpfch.org\/ko\/impact-stories\/from-loss-comes-hope\/","title":{"rendered":"\uc0c1\uc2e4\uc5d0\uc11c \ud76c\ub9dd\uc774 \uc628\ub2e4"},"content":{"rendered":"<h4><em>\uc0c8\ub85c\uc6b4 \uba74\uc5ed \uce58\ub8cc\ubc95\uc774 \uce58\uba85\uc801\uc778 \ub1cc\uc885\uc591 \ud658\uc790\uc5d0\uac8c \ud6a8\uacfc\uac00 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4.<\/em><\/h4>\n<p>\uc81c\uc774\uc2a4 \uc6cc\ub4dc\uac00 2020\ub144 9\uc6d4 \uc2a4\ud0e0\ud37c\ub4dc \ub8e8\uc2e4 \ud328\ucee4\ub4dc \uc5b4\ub9b0\uc774 \ubcd1\uc6d0\uc5d0 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95 \uc784\uc0c1\uc2dc\ud5d8\uc5d0 \ucc38\uc5ec\ud558\uae30 \uc704\ud574 \uc654\uc744 \ub54c, \uadf8\ub294 1\ub144 \ub118\uac8c \uce58\uba85\uc801\uc778 \ub1cc\uac04 \uc885\uc591\uacfc \uc2f8\uc6b0\uace0 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\uc758 \uc9c4\ub2e8\uc740 \ubbf8\ub9cc\uc131 \ub0b4\uc778\uc131 \ub1cc\uad50\uc885(DIPG)\uc774\uc5c8\ub294\ub370, \uae30\uc874\uc758 \uc554 \uce58\ub8cc\ubc95\uc73c\ub85c\ub294 \uce58\ub8cc\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \uc774 \uc9c8\ubcd1\uc758 5\ub144 \uc0dd\uc874\uc728\uc740 1% \ubbf8\ub9cc\uc785\ub2c8\ub2e4.<\/p>\n<p>\uc81c\uc774\uc2a4 \uac19\uc740 \ud658\uc790\uc5d0\uac8c\ub294 \ud76c\ub9dd\uc774 \uc5c6\uc5c8\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc \uadf8\uac00 \ucc99\uc218\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub610 \ub2e4\ub978 \ubc00\uc811\ud55c \uad00\ub828 \uc554\uc778 DIPG(\ub514\ud504\ud14c\ub9ac\uc544\uc131 \ubc31\ud608\ubcd1) \ud658\uc790 \ub124 \uba85 \uc911 \ud55c \uba85\uc774 \ub418\uae30 \uc804\uae4c\uc9c0\ub294 \ub9d0\uc785\ub2c8\ub2e4. \uc774 \uc9c8\ubcd1\uacfc \uc2f8\uc6b0\ub3c4\ub85d \uc124\uacc4\ub41c \uba74\uc5ed \uc138\ud3ec\ub97c \ud22c\uc5ec\ubc1b\uc740 \uccab \ubc88\uc9f8 \ud658\uc790\uc600\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \uc2dc\ud5d8 \ub300\uc0c1 \ud658\uc790\uac00 \uc9c8\ubcd1\uc774\ub098 \ud569\ubcd1\uc99d\uc73c\ub85c \uc0ac\ub9dd\ud588\uc9c0\ub9cc, \uadf8\uc911 \uc138 \uba85\uc740 \uc124\uacc4\ub41c \uc138\ud3ec\ub85c\ubd80\ud130 \uc0c1\ub2f9\ud55c \uc784\uc0c1\uc801 \ud6a8\uacfc\ub97c \uacbd\ud5d8\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc774 \uc5f0\uad6c\uc758 \ucc45\uc784 \uc5f0\uad6c\uc790\uc774\uc790 \uc18c\uc544 \uc2e0\uacbd\uc885\uc591\ud559\uc790\uc778 \ubbf8\uc178 \ubaac\uc81c(MD, PhD) \ubc15\uc0ac\ub294 &quot;\uc774 \ub124 \uba85\uc758 \ud658\uc790\ub4e4\uc740 \uc601\uc6c5\uc785\ub2c8\ub2e4.&quot;\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uadf8\ub4e4\uc740 \uc6b0\ub9ac\uc5d0\uac8c \ub9ce\uc740 \uac83\uc744 \uac00\ub974\uccd0 \uc8fc\uc5c8\uace0, \uadf8 \uc9c0\uc2dd\uc740 \uc774\ubbf8 \ub2e4\ub978 \uc544\uc774\ub4e4\uc744 \ub3d5\ub294 \ub370 \ud65c\uc6a9\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.&quot;<\/p>\n<p>FDA\ub294 2017\ub144\uc5d0 \ud608\uc561\uc554 \uce58\ub8cc\ub97c \uc704\ud574 CAR-T \uc138\ud3ec\ub77c\uace0\ub3c4 \ud558\ub294 \uc870\uc791\ub41c \uba74\uc5ed \uc138\ud3ec\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83\uc744 \uc2b9\uc778\ud588\uc9c0\ub9cc, \uc774 \uae30\uc220\uc774 \uace0\ud615 \uc885\uc591\uc5d0 \ud6a8\uacfc\uac00 \uc788\uc5c8\ub358 \uc801\uc740 \uc5c6\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc5f0\uad6c\ud300\uc740 \uc544\uc9c1 \uc774 \uc720\ud615\uc758 \uc2e0\uacbd\uad50\uc885\uc744 \uce58\ub8cc\ud558\ub294 \ubc29\ubc95\uc744 \uac1c\ubc1c\ud558\uc9c0 \ubabb\ud588\uc9c0\ub9cc, \uc774\ubc88 \uc5f0\uad6c \uacb0\uacfc\ub97c \uc911\uc694\ud55c \uc774\uc815\ud45c\ub85c \uc5ec\uae41\ub2c8\ub2e4.<\/p>\n<p>&quot;\uc774 \ubb34\uc11c\uc6b4 \uc9c8\ubcd1\uc5d0\uc11c CAR-T \uc138\ud3ec \uce58\ub8cc\ubc95\uc774 \uc0c1\ub2f9\ud55c \ud56d\uc885\uc591 \ud6a8\uacfc\ub97c \ubcf4\uc774\ub294 \uac83\uc744 \ud655\uc778\ud588\uc2b5\ub2c8\ub2e4.&quot;\ub77c\uace0 \ubaac\uc81c\uc640 \ud568\uaed8 \uc0c8\ub85c\uc6b4 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud55c \ud06c\ub9ac\uc2a4\ud0c8 \ub9e5\uce7c \ubc15\uc0ac\ub294 \ub9d0\ud588\uc2b5\ub2c8\ub2e4. \ub9e5\uce7c \ubc15\uc0ac\ub294 \uc554 \uba74\uc5ed\uc694\ubc95 \uc804\ubb38\uac00\uc774\uc790 \uc5b4\ub2c8\uc2a4\ud2b8 &amp; \uc544\uba5c\ub9ac\uc544 \uac08\ub85c \uac00\uc871 \uc18c\uc544\uacfc \ubc0f \ub0b4\uacfc \uad50\uc218\uc785\ub2c8\ub2e4. \uadf8\ub140\ub294 &quot;\uc774\ubc88 \uc5f0\uad6c \uacb0\uacfc\ub294 \uc774 \uc885\uc591\ubfd0\ub9cc \uc544\ub2c8\ub77c \ub2e4\uc591\ud55c \uc720\ud615\uc758 \ub1cc\uc885\uc591\uc5d0 \ud76c\ub9dd\uc801\uc778 \uc2e0\ud638\uc785\ub2c8\ub2e4.&quot;\ub77c\uace0 \ub367\ubd99\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ub9e5\uce7c\uacfc \ubaac\uc81c\uc758 \uc5f0\uad6c\ub294 \uae30\ubd80\uc790\ub4e4\uc758 \uc544\ub08c\uc5c6\ub294 \uc790\uc120 \uc9c0\uc6d0\uc744 \ud1b5\ud574 \uac00\ub2a5\ud588\uc2b5\ub2c8\ub2e4. \uae30\ubd80\uc790 \uc911 \ub9ce\uc740 \uc218\uac00 \uc774 \uc9c8\ubcd1\uc73c\ub85c \uc778\ud574 \uc790\ub140\ub97c \uc783\uc740 \ubd80\ubaa8\ub4e4\uc774\uba70 \uce58\ub8cc\ubc95\uc744 \ucc3e\uae30 \uc704\ud574 \ud5cc\uc2e0\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<h3>\uc81c\uc774\uc2a4 \uc6cc\ub4dc \uc0ac\uac74<\/h3>\n<p>\uc81c\uc774\uc2a4\ub294 2019\ub144 \ucd08, \uba87 \uc8fc\uac04 \uc8fc\ubcc0 \uc2dc\uc57c \uc7a5\uc560\ub97c \uacaa\uc740 \ud6c4 \uc2e0\uacbd\uad50\uc885 \uc9c4\ub2e8\uc744 \ubc1b\uc558\uc744 \ub2f9\uc2dc 20\uc138\uc600\uc2b5\ub2c8\ub2e4. \uadf8\uc640 \uadf8\uc758 \uac00\uc871\uc740 \uc9c4\ub2e8 \uacb0\uacfc\uc5d0 \ucda9\uaca9\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \uce94\uc790\uc2a4\uc5d0 \uc788\ub294 \uc81c\uc774\uc2a4\uc758 \uc2e0\uacbd\uacfc \uc804\ubb38\uc758\ub294 \uadf8\uc758 \ub0a8\uc740 \uc218\uba85\uc774 6\uac1c\uc6d4\uc5d0\uc11c 9\uac1c\uc6d4\uc774\ub77c\uace0 \uc608\uce21\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ub3d9\uc815\uc801 \uc0ac\uc6a9(compassionate use) \ubc29\uc2dd\uc73c\ub85c \uc2e4\ud5d8\uc801 \ud56d\uc554 \ud654\ud559\uc694\ubc95\uc81c\ub97c \ud22c\uc5ec\ubc1b\uc558\uace0, \uc2a4\ud0e0\ud37c\ub4dc \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \ucc38\uc5ec\ud560 \uae30\ud68c\uac00 \uc0dd\uae30\uae30 \uc804\uae4c\uc9c0 \uac70\uc758 14\uac1c\uc6d4 \ub3d9\uc548 \uc774 \ubcd1\uc744 \uc553\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uadf8\uc640 \uadf8\uc758 \uc5c4\ub9c8 \ub9ac\uc0ac\uac00 \uc2a4\ud0e0\ud37c\ub4dc\uc5d0 \ub3c4\ucc29\ud588\uc744 \ub54c\ucbe4\uc5d0\ub294 \uc885\uc591\uc774 \uc810\uc810 \ub354 \uc9c4\ud589\ub418\uace0 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc81c\uc774\uc2a4\ub294 \uc774 \uc2e4\ud5d8\uc774 \uc790\uc2e0\uc758 \ubaa9\uc228\uc744 \uad6c\ud560 \uc218 \uc5c6\uc744 \uac83 \uac19\ub2e4\ub294 \uac83\uc744 \uc54c\uace0 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. &quot;\uadf8\ub294 &#039;\ub0b4\uac00 \uc8fd\uc744 \uac70\ub77c\ub294 \uac78 \uc54c\uc544\uc694. \uadf8\ub9ac\uace0 \uc774\uac74 \uc54c\uc544\uc694.&#039;\ub77c\uace0 \ub9d0\ud588\uc5b4\uc694.&quot;<\/p>\n<p>&quot;\uc5b8\uc820\uac00\ub294 \uce58\ub8cc\uac00 \ub2e4\ub978 \uc544\uc774\ub4e4\uc744 \uce58\ub8cc\ud558\ub294 \ubc29\ubc95\uc774 \ub420 \uac70\uc608\uc694.&quot; \ubaac\uc81c\ub294 \ud68c\uc0c1\ud55c\ub2e4. &quot;\uac15\uc778\ud558\uace0 \ucd95\uad6c\ub97c \uc798\ud558\ub294 21\uc0b4 \uc18c\ub144\uc774 \uc81c\uac8c &#039;\ub2e4\uc12f \uc0b4\uc9dc\ub9ac \uc544\uc774\uac00 \uba3c\uc800 \uce58\ub8cc\ub97c \ubc1b\ub294 \uac74 \uc6d0\uce58 \uc54a\uc544\uc694.&#039;\ub77c\uace0 \ub9d0\ud588\uc5b4\uc694.&quot;<\/p>\n<h3>&quot;\ub098\ub294 \uc8fd\uc744 \uc218 \uc5c6\uc5b4. \ubc14\ube60.&quot;<\/h3>\n<p>\uc81c\uc774\uc2a4\uac00 CAR-T \uc138\ud3ec \uc784\uc0c1\uc2dc\ud5d8\uc5d0 \ucc38\uc5ec\ud588\uc744 \ub2f9\uc2dc, \uadf8\ub294 \uce94\uc790\uc2a4 \uc8fc\ub9bd\ub300\ud559\uad50 3\ud559\ub144\uc73c\ub85c \uae30\uc5c5\uac00 \uc815\uc2e0\uacfc \ubc95\ud559\uc744 \uc804\uacf5\ud558\uace0 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc9c4\ub2e8 \ud6c4, \uc81c\uc774\uc2a4\ub294 DIPG(\ubc1c\ub2ec\uc131 \ubc31\ud608\ubcd1)\ub97c \uc553\uace0 \uc788\ub294 \uc544\uc774\ub4e4\uc744 \uc704\ud55c \uc639\ud638\uc790\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ub9ac\uc0ac\ub294 &quot;\uc81c\uc774\uc2a4\ub294 \uc758\ud68c, \uad6d\ub9bd\ubcf4\uac74\uc6d0, \ud76c\uadc0\uc554\uc5d0 \ub300\ud55c \uc628\ub77c\uc778 \ud3ec\ub7fc\uc5d0\uc11c \uc5f0\uc124\ud588\uc2b5\ub2c8\ub2e4.&quot;\ub77c\uace0 \ub9d0\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uc81c\uc774\uc2a4\ub294 \uc554 \uc5f0\uad6c \ubc0f \uce58\ub8cc \uc811\uadfc\uc131 \ud655\ub300\ub97c \uc704\ud574 1,000\ub9cc \ub2ec\ub7ec(\uc57d 25\uc5b5 \uc6d0) \uc774\uc0c1\uc744 \ubaa8\uae08\ud55c \ucea0\ud398\uc778\uc5d0 \ucc38\uc5ec\ud588\uc2b5\ub2c8\ub2e4. \ub610\ud55c \ub1cc\uc885\uc591 \uc5b4\ub9b0\uc774\ub4e4\uc774 \ucc38\uc5ec\ud560 \uc218 \uc788\ub294 \uc784\uc0c1 \uc2dc\ud5d8\uc5d0 \ub300\ud55c \uc804\ubb38\uac00 \uc758\uacac\uc744 \uc5bb\uc744 \uc218 \uc788\ub3c4\ub85d \ub3d5\ub294 \ube44\uc601\ub9ac \ub2e8\uccb4\ub97c \uc124\ub9bd\ud558\ub294 \ub370\uc5d0\ub3c4 \ud798\uc37c\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ub9ac\uc0ac\ub294 &quot;\uc81c\uc774\uc2a4\ub294 \uce5c\uad6c\ub4e4\uacfc \uac00\uc871\ub4e4\uc5d0\uac8c &#039;\ub09c \uc8fd\uc744 \uc218 \uc5c6\uc5b4. \ubc14\ube60\uc11c&#039;\ub77c\uace0 \uc704\ub85c\ud558\uace4 \ud588\uc5b4\uc694.&quot;\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uadf8\uac8c \uc81c\uc774\uc2a4\uc758 \uc8fc\ubb38\uc774 \ub418\uc5c8\uc8e0.&quot;<\/p>\n<p>\uc81c\uc774\uc2a4\uac00 CAR-T \uc138\ud3ec\ub97c \ucc98\uc74c \uc8fc\uc785\ubc1b\uc740 \uc9c0 \uc77c\uc8fc\uc77c \ud6c4, \uadf8\ub294 \ubc1c\uc5f4\uacfc \uc800\ud608\uc555, \uc0ac\uc774\ud1a0\uce74\uc778 \uc99d\uac00 \uc9d5\ud6c4\ub97c \ubcf4\uc600\uc73c\uba70 \uc2e0\uacbd\ud559\uc801 \uc99d\uc0c1\uc774 \uc545\ud654\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ud558\uc9c0\ub9cc 2\uc8fc\uac00 \uc9c0\ub098\uc790 \uc99d\uc0c1\uc774 \uc644\ud654\ub418\uace0 \uc5bc\uad74\uc5d0 \uac10\uac01\uc774 \ub354 \uc88b\uc544\uc84c\uc2b5\ub2c8\ub2e4. \uc774\uc804\uc5d0\ub294 \uc5b4\uc0c9\ud588\ub358 \uac78\uc74c\uac78\uc774\ub3c4 \uac70\uc758 \uc815\uc0c1\uc73c\ub85c \ub3cc\uc544\uc654\uc2b5\ub2c8\ub2e4. \ud55c \ub2ec \ub9cc\uc5d0 \uc2e0\uacbd\ud559\uc801 \uac80\uc0ac \uacb0\uacfc\ub3c4 \uac70\uc758 \uc815\uc0c1\uc73c\ub85c \ub3cc\uc544\uc654\uc2b5\ub2c8\ub2e4.<\/p>\n<p>&quot;\uae09\uaca9\ud558\uac8c \uc9c4\ud589\ub418\ub294 DIPG\ub97c \uc553\ub358 \uc80a\uc740\uc774\uac00 \uac70\uc758 \uc815\uc0c1\uc801\uc778 \uc2e0\uacbd\ud559\uc801 \uac80\uc0ac\ub97c \ubc1b\ub294 \ubaa8\uc2b5\uc744 \ubcf4\ub294 \uac74 \uc804\ub840 \uc5c6\ub294 \uc77c\uc785\ub2c8\ub2e4.&quot;\ub77c\uace0 \ubaac\uc81c\ub294 \ub9d0\ud569\ub2c8\ub2e4. &quot;\uc5b8\uc820\uac00\ub294 \uc774 \ubcd1\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\uc744 \uac70\ub77c\ub294 \uc0dd\uac01\uc774 \ucc98\uc74c\uc73c\ub85c \ub4e4\uc5c8\uc2b5\ub2c8\ub2e4.&quot;<\/p>\n<p>\uc81c\uc774\uc2a4\ub294 2021\ub144 2\uc6d4, \uc544\ubc84\uc9c0 \ub85c\uc800\uc640 \ud568\uaed8 \uc288\ud37c\ubcfc\uc5d0 \uac00\uc11c \uc0ac\ub791\ud558\ub294 \uace0\ud5a5 \ud300\uc778 \uce94\uc790\uc2a4\uc2dc\ud2f0 \uce58\ud504\uc2a4\uc758 \uacbd\uae30\ub97c \ubcf4\ub294 \uafc8\uc744 \uc774\ub8f0 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \ub9ac\uc0ac\ub294 &quot;\uc81c\uc774\uc2a4\ub294 \uc815\ub9d0 \ud070 \uc790\uc720\ub97c \uc5bb\uc5c8\uace0, \ud76c\ub9dd\uc758 \ube5b\uc774 \ube44\uce58\ub294 \uac83 \uac19\uc558\uc5b4\uc694.&quot;\ub77c\uace0 \ub9d0\ud569\ub2c8\ub2e4. 2021\ub144 6\uc6d4 30\uc77c, \uc81c\uc774\uc2a4\ub294 \uc138\uc778\ud2b8\ub8e8\uc774\uc2a4 \ubcd1\uc6d0\uc5d0 \uc785\uc6d0\ud588\uace0 7\uc6d4 3\uc77c\uc5d0 \uc138\uc0c1\uc744 \ub5a0\ub0ac\uc2b5\ub2c8\ub2e4. \uc2ac\ud514\uc5d0 \uc7a0\uae34 \ubd80\ubaa8\ub2d8, \ud615, \ub204\ub098, \ud615\uc218, \uadf8\ub9ac\uace0 \uc870\uce74\ub97c \ub0a8\uaca8\ub450\uace0 \ub9d0\uc785\ub2c8\ub2e4.<\/p>\n<p>&quot;\uc81c\uc774\uc2a4\uac00 DIPG\uac00 \ubb54\uc9c0\ub3c4 \ubaa8\ub978 \ucc44 \uc5ec\uae30 \uc788\uc5c8\uc73c\uba74 \uc88b\uc558\uc744 \ud150\ub370. \ubb3c\ub860\uc774\uc8e0.&quot; 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