{"id":20948,"date":"2025-05-16T17:00:05","date_gmt":"2025-05-16T17:00:05","guid":{"rendered":"https:\/\/lpfch.org\/?p=20948"},"modified":"2025-05-22T18:17:30","modified_gmt":"2025-05-22T18:17:30","slug":"supercharging-car-t-cell-therapy","status":"publish","type":"post","link":"https:\/\/lpfch.org\/tl\/impact-stories\/supercharging-car-t-cell-therapy\/","title":{"rendered":"Supercharging CAR T-Cell Therapy"},"content":{"rendered":"<p><span data-contrast=\"auto\">Sa nakalipas na 50 taon, ang mga mananaliksik ay gumawa ng hindi kapani-paniwalang pag-unlad sa pagpapagamot ng pediatric cancer. Habang humigit-kumulang 60% ng mga batang pasyente ng kanser ang namatay mula sa kanilang sakit noong kalagitnaan ng 1970s, ngayon, 85% ng mga pasyente ang nakaligtas. Ang pag-unlad na ito ay posible lamang sa pamamagitan ng mga klinikal na pagsubok na pinamumunuan ng mga akademikong sentrong medikal tulad ng Lucile Packard Children&#039;s Hospital Stanford.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Sa kabila ng mga pagsulong na ito, ang kanser ay nananatiling pangunahing sanhi ng pagkamatay ng sakit sa mga batang may edad 15 pababa. Para sa mga maaaring gumaling, ang malupit na paggamot ay kadalasang nagdudulot ng mga hamon sa kalusugan sa bandang huli ng buhay, tulad ng pinsala sa organ, kawalan ng katabaan, o pangalawang kanser.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><a href=\"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/CAR-T_Graphic_color_art.png\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-20955 size-full\" src=\"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/CAR-T_Graphic_color_art.png\" alt=\"\" width=\"1600\" height=\"1025\" \/><\/a><\/p>\n<p><em>Ilustrasyon ni Alece Birnbach<\/em><\/p>\n<p><span data-contrast=\"none\">C<\/span><span data-contrast=\"none\">rystal Mackall, MD, ang <\/span><i><span data-contrast=\"none\">Ernest at Amelia Gallo Family Professor, <\/span><\/i><span data-contrast=\"none\">propesor ng pediatrics at medisina, at sentro<\/span> <span data-contrast=\"none\">direktor para sa Parker Institute for Cancer<\/span> <span data-contrast=\"none\">Immunotherapy sa Stanford Medicine, ay nangunguna sa<\/span> <span data-contrast=\"none\">singilin upang mag-alok ng pag-asa para sa mga bata na higit na nangangailangan nito. Para sa higit pa<\/span> <span data-contrast=\"none\">higit sa 40 taon, si Mackall ay naging pioneer sa cancer<\/span> <span data-contrast=\"none\">immunotherapy\u2014isang larangan na gumagamit ng sariling katawan<\/span> <span data-contrast=\"none\">immune cells upang labanan ang sakit. Noong 2017, inilunsad si Mackall<\/span> <span data-contrast=\"none\">ang Center for Cancer Cell Therapy sa Stanford para isulong<\/span> <span data-contrast=\"none\">mga breakthrough mula sa lab hanggang sa bedside ng mga pasyente bilang<\/span> <span data-contrast=\"none\">mabilis hangga&#039;t maaari.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">&quot;Ang Stanford ay, sa aking opinyon, ang lugar kung saan ang pinaka-malikhaing agham ay ginagawa sa buong mundo,&quot; sabi ni Mackall. &quot;Nais kong bumuo ng mga cell therapy dito dahil alam kong magagawa kong magtrabaho kasama ang ilan sa mga pinaka-kahanga-hangang isip-mga investigator na interesado sa mga bagay tulad ng synthetic biology, artificial intelligence, translational research, at human immunology.&quot;<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Ang koponan ni Mackall ay nangunguna sa mga rebolusyonaryong pagpapabuti sa mga chimeric antigen receptor (CAR) T-cell na mga therapies. Ang pamamaraang ito, na naging kapansin-pansing epektibo laban sa ilang mga kanser sa dugo, ay inhinyero ang immune system ng isang pasyente upang hanapin at sirain ang mga selula ng kanser. Ngayon ay nagsusumikap si Mackall na gawing epektibo ang paggamot na ito para sa mga solidong kanser at mga tumor sa utak, na may pangunahing pagtutok sa mga bata. Nakipagtulungan si Mackall kay Michelle Monje, MD, PhD, ang <\/span><i><span data-contrast=\"none\">Milan Gambhir Propesor ng Pediatric Neuro-Oncology, <\/span><\/i><span data-contrast=\"none\">sa isang malaking tagumpay gamit ang CAR T cells upang gamutin ang diffuse intrinsic pontine glioma, isang pediatric brain tumor na itinuturing na nakamamatay sa pangkalahatan\u2014hanggang ngayon.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Ang tagumpay na ito ay na-catalyzed ng malawak na suporta ng donor, at alam ni Mackall na ito ay simula pa lamang. Gumagawa siya ng tinatawag niyang &quot;next-gen&quot; na mga immunotherapies\u2014pagbuo sa mga kasalukuyang teknolohiya upang gawing mas ligtas, mas epektibo, at mas epektibo ang mga immunotherapies.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Ang isa sa mga inobasyong ito ay idinisenyo upang mapabuti ang kahabaan ng buhay, kaligtasan, at pagiging epektibo ng CAR T-cell therapies. Natuklasan ni Mackall at ng kanyang koponan na maaari silang gumamit ng isang umiiral nang gamot\u2014isang tabletang hepatitis na inaprubahan ng FDA\u2014upang &quot;i-on&quot; ang mga natutulog na CAR pagkatapos na maipasok ang mga ito pabalik sa pasyente<\/span><i><span data-contrast=\"none\">\u02bc<\/span><\/i><span data-contrast=\"none\">ng katawan. Ang bagong pamamaraang ito, na tinatawag na &quot;SNIP CAR T,&quot; ay nagbibigay sa kanila ng hindi pa nagagawang kontrol sa hindi lamang kung kailan at kung saan inilalagay ang paggamot, kundi pati na rin ang antas ng pag-activate.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">&quot;Gumawa kami ng &#039;remote-controlled&#039; na CAR T-cell therapy na naaayos para sa bawat pasyente,&quot; paliwanag ni Mackall. &quot;Ang binagong CAR T cells ay hindi lamang mas ligtas, ngunit mas makapangyarihan din ang mga ito at mas maraming nalalaman kaysa sa orihinal na CAR T cells.&quot;<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Ang makabagong agham tulad ng Mackall&#039;s ay mangangailangan ng matatag na suporta mula sa mga mamumuhunan na nag-iisip ng pasulong. Gayunpaman, ang ganitong uri ng suporta ay maaaring mahirap makuha sa pamamagitan ng tradisyonal na mga mapagkukunan ng pagpopondo.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">&quot;Ang mga kumpanya ng venture capital at biopharmaceutical ay hindi karaniwang namumuhunan sa mga bihirang sakit, at lahat ng mga kanser ng mga bata ay mga bihirang sakit,&quot; paliwanag niya. &quot;Ngunit ang aming layunin ay gumawa ng nakakagambalang agham. Gusto naming baguhin ang paraan ng pagtrato sa mga pasyente sa hinaharap.&quot;<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Ang suportang pilantropo ay nagpasigla sa mga natuklasan ni Mackall at magiging kritikal habang sumusulong siya. Ang mga donor na tulad ni Chris Gallo\u2014na ang pamilya ay nagtatag ng isang endowed professorship para kay Mackall\u2014ay nakatuon sa pagpapasigla sa kanyang mahalagang gawain. Alam ni Gallo na mas mabilis ang pag-unlad kung makikiisa ang ibang mga pilantropo.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">&quot;Ang aming pamilya ay matagal nang tagasuporta ng makabagong agham tulad ng pananaliksik ni Dr. Mackall na humahantong sa mas mahusay na paggamot para sa mga bata,&quot; sabi ni Gallo. &quot;Kami ay ipinagmamalaki na ipagpatuloy ang legacy na ito sa aming pagkakawanggawa.&quot;<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Sa napakalaking tagumpay at walang katapusang posibilidad, itinatakda ni Mackall ang kurso para sa isang bagong panahon ng medisina at isang mas malusog na hinaharap para sa mga bata.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\"> <\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Sa nakalipas na 50 taon, ang mga mananaliksik ay gumawa ng hindi kapani-paniwalang pag-unlad sa pagpapagamot ng pediatric cancer. Habang humigit-kumulang 60% ng mga batang pasyente ng kanser ang namatay dahil sa kanilang sakit...<\/p>","protected":false},"author":7,"featured_media":20951,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[148],"class_list":["post-20948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-the-news","health_topic-pediatric-cancer"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Supercharging CAR T-Cell Therapy - Lucile Packard Foundation for Children&#039;s Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lpfch.org\/tl\/impact-stories\/supercharging-car-t-cell-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Supercharging CAR T-Cell Therapy\" \/>\n<meta property=\"og:description\" content=\"Over the past 50 years, researchers have made incredible progress in treating pediatric cancer. While about 60% of young cancer patients died from their disease...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/lpfch.org\/tl\/impact-stories\/supercharging-car-t-cell-therapy\/\" \/>\n<meta property=\"og:site_name\" content=\"Lucile Packard Foundation for Children&#039;s Health\" \/>\n<meta property=\"article:published_time\" content=\"2025-05-16T17:00:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-22T18:17:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/570A5356-1024x683.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"683\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"brian.pendergast\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"brian.pendergast\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/\"},\"author\":{\"name\":\"brian.pendergast\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/km\\\/#\\\/schema\\\/person\\\/9895de43ccd8af24fe591c84bb4d5d07\"},\"headline\":\"Supercharging CAR T-Cell Therapy\",\"datePublished\":\"2025-05-16T17:00:05+00:00\",\"dateModified\":\"2025-05-22T18:17:30+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/\"},\"wordCount\":677,\"image\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/lpfch.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/570A5356.png\",\"articleSection\":[\"In the News\"],\"inLanguage\":\"tl\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/\",\"url\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/\",\"name\":\"Supercharging CAR T-Cell Therapy - Lucile Packard Foundation for Children&#039;s Health\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/km\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/lpfch.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/570A5356.png\",\"datePublished\":\"2025-05-16T17:00:05+00:00\",\"dateModified\":\"2025-05-22T18:17:30+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/km\\\/#\\\/schema\\\/person\\\/9895de43ccd8af24fe591c84bb4d5d07\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/#breadcrumb\"},\"inLanguage\":\"tl\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tl\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/#primaryimage\",\"url\":\"https:\\\/\\\/lpfch.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/570A5356.png\",\"contentUrl\":\"https:\\\/\\\/lpfch.org\\\/wp-content\\\/uploads\\\/2025\\\/05\\\/570A5356.png\",\"width\":1600,\"height\":1067,\"caption\":\"Dr Crystal Mackall poses in her lab with her team.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/impact-stories\\\/supercharging-car-t-cell-therapy\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/lpfch.org\\\/km\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Supercharging CAR T-Cell&hellip;\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/km\\\/#website\",\"url\":\"https:\\\/\\\/lpfch.org\\\/km\\\/\",\"name\":\"Lucile Packard Foundation for Children&#039;s Health\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/lpfch.org\\\/km\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tl\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/km\\\/#\\\/schema\\\/person\\\/9895de43ccd8af24fe591c84bb4d5d07\",\"name\":\"brian.pendergast\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tl\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/0dcdb9a925c4f258a9f8d40f548ea898ec3bf75801a0c9c8fc158d93031c7e10?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/0dcdb9a925c4f258a9f8d40f548ea898ec3bf75801a0c9c8fc158d93031c7e10?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/0dcdb9a925c4f258a9f8d40f548ea898ec3bf75801a0c9c8fc158d93031c7e10?s=96&d=mm&r=g\",\"caption\":\"brian.pendergast\"},\"url\":\"https:\\\/\\\/lpfch.org\\\/tl\\\/impact-stories\\\/author\\\/brian-pendergast\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Supercharging CAR T-Cell Therapy - Lucile Packard Foundation para sa Kalusugan ng mga Bata","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/lpfch.org\/tl\/impact-stories\/supercharging-car-t-cell-therapy\/","og_locale":"en_US","og_type":"article","og_title":"Supercharging CAR T-Cell Therapy","og_description":"Over the past 50 years, researchers have made incredible progress in treating pediatric cancer. While about 60% of young cancer patients died from their disease...","og_url":"https:\/\/lpfch.org\/tl\/impact-stories\/supercharging-car-t-cell-therapy\/","og_site_name":"Lucile Packard Foundation for Children&#039;s Health","article_published_time":"2025-05-16T17:00:05+00:00","article_modified_time":"2025-05-22T18:17:30+00:00","og_image":[{"width":1024,"height":683,"url":"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/570A5356-1024x683.png","type":"image\/png"}],"author":"brian.pendergast","twitter_card":"summary_large_image","twitter_misc":{"Written by":"brian.pendergast","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/#article","isPartOf":{"@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/"},"author":{"name":"brian.pendergast","@id":"https:\/\/lpfch.org\/km\/#\/schema\/person\/9895de43ccd8af24fe591c84bb4d5d07"},"headline":"Supercharging CAR T-Cell Therapy","datePublished":"2025-05-16T17:00:05+00:00","dateModified":"2025-05-22T18:17:30+00:00","mainEntityOfPage":{"@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/"},"wordCount":677,"image":{"@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/570A5356.png","articleSection":["In the News"],"inLanguage":"tl"},{"@type":"WebPage","@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/","url":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/","name":"Supercharging CAR T-Cell Therapy - Lucile Packard Foundation para sa Kalusugan ng mga Bata","isPartOf":{"@id":"https:\/\/lpfch.org\/km\/#website"},"primaryImageOfPage":{"@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/#primaryimage"},"image":{"@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/#primaryimage"},"thumbnailUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/570A5356.png","datePublished":"2025-05-16T17:00:05+00:00","dateModified":"2025-05-22T18:17:30+00:00","author":{"@id":"https:\/\/lpfch.org\/km\/#\/schema\/person\/9895de43ccd8af24fe591c84bb4d5d07"},"breadcrumb":{"@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/#breadcrumb"},"inLanguage":"tl","potentialAction":[{"@type":"ReadAction","target":["https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/"]}]},{"@type":"ImageObject","inLanguage":"tl","@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/#primaryimage","url":"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/570A5356.png","contentUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2025\/05\/570A5356.png","width":1600,"height":1067,"caption":"Dr Crystal Mackall poses in her lab with her team."},{"@type":"BreadcrumbList","@id":"https:\/\/lpfch.org\/impact-stories\/supercharging-car-t-cell-therapy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lpfch.org\/km\/"},{"@type":"ListItem","position":2,"name":"Supercharging CAR T-Cell&hellip;"}]},{"@type":"WebSite","@id":"https:\/\/lpfch.org\/km\/#website","url":"https:\/\/lpfch.org\/km\/","name":"Lucile Packard Foundation para sa Kalusugan ng mga Bata","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lpfch.org\/km\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tl"},{"@type":"Person","@id":"https:\/\/lpfch.org\/km\/#\/schema\/person\/9895de43ccd8af24fe591c84bb4d5d07","name":"brian.pendergast","image":{"@type":"ImageObject","inLanguage":"tl","@id":"https:\/\/secure.gravatar.com\/avatar\/0dcdb9a925c4f258a9f8d40f548ea898ec3bf75801a0c9c8fc158d93031c7e10?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/0dcdb9a925c4f258a9f8d40f548ea898ec3bf75801a0c9c8fc158d93031c7e10?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/0dcdb9a925c4f258a9f8d40f548ea898ec3bf75801a0c9c8fc158d93031c7e10?s=96&d=mm&r=g","caption":"brian.pendergast"},"url":"https:\/\/lpfch.org\/tl\/impact-stories\/author\/brian-pendergast\/"}]}},"_links":{"self":[{"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/posts\/20948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/comments?post=20948"}],"version-history":[{"count":7,"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/posts\/20948\/revisions"}],"predecessor-version":[{"id":21006,"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/posts\/20948\/revisions\/21006"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/media\/20951"}],"wp:attachment":[{"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/media?parent=20948"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lpfch.org\/tl\/wp-json\/wp\/v2\/categories?post=20948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}