{"id":20948,"date":"2025-05-16T17:00:05","date_gmt":"2025-05-16T17:00:05","guid":{"rendered":"https:\/\/lpfch.org\/?p=20948"},"modified":"2025-05-22T18:17:30","modified_gmt":"2025-05-22T18:17:30","slug":"supercharging-car-t-cell-therapy","status":"publish","type":"post","link":"https:\/\/lpfch.org\/vi\/impact-stories\/supercharging-car-t-cell-therapy\/","title":{"rendered":"Li\u1ec7u ph\u00e1p t\u0103ng c\u01b0\u1eddng t\u1ebf b\u00e0o T CAR"},"content":{"rendered":"

Trong 50 n\u0103m qua, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng ti\u1ebfn b\u1ed9 \u0111\u00e1ng kinh ng\u1ea1c trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 nhi khoa. Trong khi kho\u1ea3ng 60% b\u1ec7nh nh\u00e2n ung th\u01b0 tr\u1ebb tu\u1ed5i t\u1eed vong v\u00ec c\u0103n b\u1ec7nh n\u00e0y v\u00e0o gi\u1eefa nh\u1eefng n\u0103m 1970, th\u00ec ng\u00e0y nay, 85% b\u1ec7nh nh\u00e2n s\u1ed1ng s\u00f3t. Ti\u1ebfn b\u1ed9 n\u00e0y ch\u1ec9 c\u00f3 th\u1ec3 \u0111\u1ea1t \u0111\u01b0\u1ee3c th\u00f4ng qua c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng do c\u00e1c trung t\u00e2m y khoa h\u00e0n l\u00e2m nh\u01b0 B\u1ec7nh vi\u1ec7n Nhi \u0111\u1ed3ng Lucile Packard Stanford d\u1eabn \u0111\u1ea7u.<\/span>\u00a0<\/span><\/p>\n

B\u1ea5t ch\u1ea5p nh\u1eefng ti\u1ebfn b\u1ed9 n\u00e0y, ung th\u01b0 v\u1eabn l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y t\u1eed vong h\u00e0ng \u0111\u1ea7u \u1edf tr\u1ebb em d\u01b0\u1edbi 15 tu\u1ed5i. \u0110\u1ed1i v\u1edbi nh\u1eefng ng\u01b0\u1eddi c\u00f3 th\u1ec3 ch\u1eefa kh\u1ecfi, c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u1eafc nghi\u1ec7t th\u01b0\u1eddng g\u00e2y ra nh\u1eefng v\u1ea5n \u0111\u1ec1 s\u1ee9c kh\u1ecfe v\u1ec1 sau, ch\u1eb3ng h\u1ea1n nh\u01b0 t\u1ed5n th\u01b0\u01a1ng n\u1ed9i t\u1ea1ng, v\u00f4 sinh ho\u1eb7c ung th\u01b0 th\u1ee9 ph\u00e1t.<\/span>\u00a0<\/span><\/p>\n

\"\"<\/a><\/p>\n

Minh h\u1ecda b\u1edfi Alece Birnbach<\/em><\/p>\n

C<\/span>rystal Mackall, MD, <\/span>Gi\u00e1o s\u01b0 gia \u0111\u00ecnh Ernest v\u00e0 Amelia Gallo, <\/span><\/i>gi\u00e1o s\u01b0 nhi khoa v\u00e0 y khoa, v\u00e0 trung t\u00e2m<\/span> gi\u00e1m \u0111\u1ed1c Vi\u1ec7n Ung th\u01b0 Parker<\/span> Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch t\u1ea1i Stanford Medicine \u0111ang d\u1eabn \u0111\u1ea7u<\/span> \u0111\u1ec3 mang l\u1ea1i hy v\u1ecdng cho nh\u1eefng \u0111\u1ee9a tr\u1ebb c\u1ea7n n\u00f3 nh\u1ea5t. \u0110\u1ec3 bi\u1ebft th\u00eam<\/span> h\u01a1n 40 n\u0103m, Mackall \u0111\u00e3 l\u00e0 ng\u01b0\u1eddi ti\u00ean phong trong l\u0129nh v\u1ef1c ung th\u01b0<\/span> li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch\u2014m\u1ed9t l\u0129nh v\u1ef1c khai th\u00e1c ch\u00ednh c\u01a1 th\u1ec3<\/span> t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch \u0111\u1ec3 ch\u1ed1ng l\u1ea1i b\u1ec7nh t\u1eadt. N\u0103m 2017, Mackall \u0111\u00e3 ra m\u1eaft<\/span> Trung t\u00e2m Li\u1ec7u ph\u00e1p T\u1ebf b\u00e0o Ung th\u01b0 t\u1ea1i Stanford \u0111\u1ec3 th\u00fac \u0111\u1ea9y<\/span> nh\u1eefng \u0111\u1ed9t ph\u00e1 t\u1eeb ph\u00f2ng th\u00ed nghi\u1ec7m \u0111\u1ebfn gi\u01b0\u1eddng b\u1ec7nh nh\u00e2n nh\u01b0<\/span> nhanh nh\u1ea5t c\u00f3 th\u1ec3.<\/span>\u00a0<\/span><\/p>\n

\u201cTheo t\u00f4i, Stanford l\u00e0 n\u01a1i khoa h\u1ecdc s\u00e1ng t\u1ea1o nh\u1ea5t th\u1ebf gi\u1edbi \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n,\u201d Mackall n\u00f3i. \u201cT\u00f4i mu\u1ed1n ph\u00e1t tri\u1ec3n li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o \u1edf \u0111\u00e2y v\u00ec t\u00f4i bi\u1ebft m\u00ecnh s\u1ebd c\u00f3 th\u1ec3 l\u00e0m vi\u1ec7c v\u1edbi nh\u1eefng b\u1ed9 \u00f3c tuy\u1ec7t v\u1eddi nh\u1ea5t\u2014nh\u1eefng nh\u00e0 nghi\u00ean c\u1ee9u quan t\u00e2m \u0111\u1ebfn nh\u1eefng l\u0129nh v\u1ef1c nh\u01b0 sinh h\u1ecdc t\u1ed5ng h\u1ee3p, tr\u00ed tu\u1ec7 nh\u00e2n t\u1ea1o, nghi\u00ean c\u1ee9u chuy\u1ec3n d\u1ecbch v\u00e0 mi\u1ec5n d\u1ecbch h\u1ecdc \u1edf ng\u01b0\u1eddi.\u201d<\/span>\u00a0<\/span><\/p>\n

Nh\u00f3m c\u1ee7a Mackall \u0111ang d\u1eabn \u0111\u1ea7u nh\u1eefng c\u1ea3i ti\u1ebfn mang t\u00ednh c\u00e1ch m\u1ea1ng trong li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T th\u1ee5 th\u1ec3 kh\u00e1ng nguy\u00ean kh\u1ea3m (CAR). Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y, v\u1ed1n \u0111\u00e3 t\u1ecf ra hi\u1ec7u qu\u1ea3 \u0111\u00e1ng k\u1ec3 trong \u0111i\u1ec1u tr\u1ecb m\u1ed9t s\u1ed1 b\u1ec7nh ung th\u01b0 m\u00e1u, gi\u00fap h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ec7nh nh\u00e2n t\u00ecm ki\u1ebfm v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0. Hi\u1ec7n nay, Mackall \u0111ang n\u1ed7 l\u1ef1c \u0111\u1ec3 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i ung th\u01b0 r\u1eafn v\u00e0 kh\u1ed1i u n\u00e3o, t\u1eadp trung ch\u1ee7 y\u1ebfu v\u00e0o tr\u1ebb em. Mackall \u0111\u00e3 h\u1ee3p t\u00e1c v\u1edbi Michelle Monje, Ti\u1ebfn s\u0129, B\u00e1c s\u0129 Y khoa, <\/span>Milan Gambhir Gi\u00e1o s\u01b0 v\u1ec1 Ung th\u01b0 th\u1ea7n kinh nhi khoa, <\/span><\/i>v\u1ec1 m\u1ed9t b\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 l\u1edbn trong vi\u1ec7c s\u1eed d\u1ee5ng t\u1ebf b\u00e0o CAR T \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb u th\u1ea7n kinh \u0111\u1ec7m c\u1ea7u n\u00e3o lan t\u1ecfa, m\u1ed9t kh\u1ed1i u n\u00e3o \u1edf tr\u1ebb em \u0111\u01b0\u1ee3c coi l\u00e0 c\u00f3 th\u1ec3 g\u00e2y t\u1eed vong cho \u0111\u1ebfn nay.<\/span>\u00a0<\/span><\/p>\n

B\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 n\u00e0y \u0111\u01b0\u1ee3c th\u00fac \u0111\u1ea9y b\u1edfi s\u1ef1 h\u1ed7 tr\u1ee3 r\u1ed9ng r\u00e3i c\u1ee7a c\u00e1c nh\u00e0 t\u00e0i tr\u1ee3, v\u00e0 Mackall bi\u1ebft r\u1eb1ng \u0111\u00e2y ch\u1ec9 l\u00e0 b\u01b0\u1edbc kh\u1edfi \u0111\u1ea7u. B\u00e0 \u0111ang ph\u00e1t tri\u1ec3n c\u00e1i m\u00e0 b\u00e0 g\u1ecdi l\u00e0 li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch "th\u1ebf h\u1ec7 ti\u1ebfp theo" - d\u1ef1a tr\u00ean c\u00e1c c\u00f4ng ngh\u1ec7 hi\u1ec7n t\u1ea1i \u0111\u1ec3 l\u00e0m cho li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch an to\u00e0n h\u01a1n, hi\u1ec7u qu\u1ea3 h\u01a1n v\u00e0 ti\u1ebft ki\u1ec7m chi ph\u00ed h\u01a1n.<\/span>\u00a0<\/span><\/p>\n

M\u1ed9t trong nh\u1eefng c\u1ea3i ti\u1ebfn n\u00e0y \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 c\u1ea3i thi\u1ec7n tu\u1ed5i th\u1ecd, \u0111\u1ed9 an to\u00e0n v\u00e0 hi\u1ec7u qu\u1ea3 c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o T CAR. Mackall v\u00e0 nh\u00f3m c\u1ee7a b\u00e0 \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng h\u1ecd c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng m\u1ed9t lo\u1ea1i thu\u1ed1c hi\u1ec7n c\u00f3 - m\u1ed9t lo\u1ea1i thu\u1ed1c vi\u00ean \u0111i\u1ec1u tr\u1ecb vi\u00eam gan \u0111\u00e3 \u0111\u01b0\u1ee3c FDA ch\u1ea5p thu\u1eadn - \u0111\u1ec3 "k\u00edch ho\u1ea1t" c\u00e1c t\u1ebf b\u00e0o CAR \u0111ang ng\u1ee7 y\u00ean sau khi ch\u00fang \u0111\u01b0\u1ee3c truy\u1ec1n tr\u1edf l\u1ea1i v\u00e0o c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n.<\/span>\u02bc<\/span><\/i>Ph\u01b0\u01a1ng ph\u00e1p m\u1edbi n\u00e0y, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 \u201cSNIP CAR T\u201d, mang l\u1ea1i cho h\u1ecd kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t ch\u01b0a t\u1eebng c\u00f3 kh\u00f4ng ch\u1ec9 v\u1ec1 th\u1eddi \u0111i\u1ec3m v\u00e0 v\u1ecb tr\u00ed tri\u1ec3n khai li\u1ec7u ph\u00e1p m\u00e0 c\u00f2n v\u1ec1 m\u1ee9c \u0111\u1ed9 k\u00edch ho\u1ea1t.<\/span>\u00a0<\/span><\/p>\n

Mackall gi\u1ea3i th\u00edch: \u201cCh\u00fang t\u00f4i \u0111\u00e3 t\u1ea1o ra m\u1ed9t li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o CAR T '\u0111i\u1ec1u khi\u1ec3n t\u1eeb xa' c\u00f3 th\u1ec3 \u0111i\u1ec1u ch\u1ec9nh cho t\u1eebng b\u1ec7nh nh\u00e2n. C\u00e1c t\u1ebf b\u00e0o CAR T \u0111\u01b0\u1ee3c c\u1ea3i ti\u1ebfn kh\u00f4ng ch\u1ec9 an to\u00e0n h\u01a1n m\u00e0 c\u00f2n m\u1ea1nh h\u01a1n v\u00e0 linh ho\u1ea1t h\u01a1n so v\u1edbi c\u00e1c t\u1ebf b\u00e0o CAR T ban \u0111\u1ea7u.\u201d<\/span>\u00a0<\/span><\/p>\n

Nh\u1eefng nghi\u00ean c\u1ee9u khoa h\u1ecdc ti\u00ean ti\u1ebfn nh\u01b0 c\u1ee7a Mackall s\u1ebd c\u1ea7n s\u1ef1 h\u1ed7 tr\u1ee3 m\u1ea1nh m\u1ebd t\u1eeb c\u00e1c nh\u00e0 \u0111\u1ea7u t\u01b0 c\u00f3 t\u01b0 duy ti\u1ebfn b\u1ed9. Tuy nhi\u00ean, lo\u1ea1i h\u1ed7 tr\u1ee3 n\u00e0y c\u00f3 th\u1ec3 kh\u00f3 c\u00f3 \u0111\u01b0\u1ee3c th\u00f4ng qua c\u00e1c ngu\u1ed3n t\u00e0i tr\u1ee3 truy\u1ec1n th\u1ed1ng.<\/span>\u00a0<\/span><\/p>\n

\u201cC\u00e1c c\u00f4ng ty \u0111\u1ea7u t\u01b0 m\u1ea1o hi\u1ec3m v\u00e0 d\u01b0\u1ee3c ph\u1ea9m sinh h\u1ecdc th\u01b0\u1eddng kh\u00f4ng \u0111\u1ea7u t\u01b0 v\u00e0o c\u00e1c b\u1ec7nh hi\u1ebfm g\u1eb7p, v\u00e0 t\u1ea5t c\u1ea3 c\u00e1c b\u1ec7nh ung th\u01b0 \u1edf tr\u1ebb em \u0111\u1ec1u l\u00e0 b\u1ec7nh hi\u1ebfm g\u1eb7p\u201d, b\u00e0 gi\u1ea3i th\u00edch. \u201cNh\u01b0ng m\u1ee5c ti\u00eau c\u1ee7a ch\u00fang t\u00f4i l\u00e0 t\u1ea1o ra m\u1ed9t n\u1ec1n khoa h\u1ecdc \u0111\u1ed9t ph\u00e1. Ch\u00fang t\u00f4i mu\u1ed1n thay \u0111\u1ed5i c\u00e1ch \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n trong t\u01b0\u01a1ng lai.\u201d<\/span>\u00a0<\/span><\/p>\n

S\u1ef1 h\u1ed7 tr\u1ee3 t\u1eeb thi\u1ec7n \u0111\u00e3 th\u00fac \u0111\u1ea9y nh\u1eefng kh\u00e1m ph\u00e1 c\u1ee7a Mackall v\u00e0 s\u1ebd r\u1ea5t quan tr\u1ecdng tr\u00ean con \u0111\u01b0\u1eddng ph\u00eda tr\u01b0\u1edbc c\u1ee7a b\u00e0. Nh\u1eefng nh\u00e0 t\u00e0i tr\u1ee3 nh\u01b0 Chris Gallo\u2014ng\u01b0\u1eddi \u0111\u00e3 trao t\u1eb7ng Mackall m\u1ed9t h\u1ecdc v\u1ecb gi\u00e1o s\u01b0 t\u00e0i tr\u1ee3\u2014cam k\u1ebft ti\u1ebfp s\u1ee9c cho c\u00f4ng tr\u00ecnh quan tr\u1ecdng c\u1ee7a b\u00e0. Gallo bi\u1ebft r\u1eb1ng ti\u1ebfn tr\u00ecnh s\u1ebd di\u1ec5n ra nhanh h\u01a1n n\u1eefa n\u1ebfu c\u00f3 s\u1ef1 tham gia c\u1ee7a c\u00e1c nh\u00e0 h\u1ea3o t\u00e2m kh\u00e1c.<\/span>\u00a0<\/span><\/p>\n

Gallo n\u00f3i: \u201cGia \u0111\u00ecnh ch\u00fang t\u00f4i t\u1eeb l\u00e2u \u0111\u00e3 \u1ee7ng h\u1ed9 nh\u1eefng nghi\u00ean c\u1ee9u khoa h\u1ecdc ti\u00ean ti\u1ebfn nh\u01b0 c\u1ee7a Ti\u1ebfn s\u0129 Mackall - nh\u1eefng nghi\u00ean c\u1ee9u d\u1eabn \u0111\u1ebfn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb t\u1ed1t h\u01a1n cho tr\u1ebb em. Ch\u00fang t\u00f4i t\u1ef1 h\u00e0o ti\u1ebfp n\u1ed1i di s\u1ea3n n\u00e0y b\u1eb1ng ho\u1ea1t \u0111\u1ed9ng t\u1eeb thi\u1ec7n c\u1ee7a m\u00ecnh.\u201d<\/span>\u00a0<\/span><\/p>\n

V\u1edbi th\u00e0nh c\u00f4ng ti\u00ean phong v\u00e0 kh\u1ea3 n\u0103ng v\u00f4 t\u1eadn, Mackall \u0111ang v\u1ea1ch ra h\u01b0\u1edbng \u0111i cho m\u1ed9t k\u1ef7 nguy\u00ean y h\u1ecdc m\u1edbi v\u00e0 m\u1ed9t t\u01b0\u01a1ng lai kh\u1ecfe m\u1ea1nh h\u01a1n cho tr\u1ebb em.<\/span>\u00a0<\/span><\/p>\n

<\/span><\/p>","protected":false},"excerpt":{"rendered":"

Trong 50 n\u0103m qua, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng ti\u1ebfn b\u1ed9 \u0111\u00e1ng kinh ng\u1ea1c trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 nhi khoa. Trong khi kho\u1ea3ng 60% b\u1ec7nh nh\u00e2n ung th\u01b0 tr\u1ebb tu\u1ed5i t\u1eed vong v\u00ec c\u0103n b\u1ec7nh n\u00e0y\u2026<\/p>","protected":false},"author":7,"featured_media":20951,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[148],"class_list":["post-20948","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-the-news","health_topic-pediatric-cancer"],"acf":[],"yoast_head":"\nSupercharging CAR T-Cell Therapy - Lucile Packard Foundation for Children's Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lpfch.org\/vi\/impact-stories\/supercharging-car-t-cell-therapy\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Supercharging CAR T-Cell Therapy\" \/>\n<meta property=\"og:description\" content=\"Over the past 50 years, researchers have made incredible progress in treating pediatric cancer. 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