{"id":3555,"date":"2014-08-21T00:26:35","date_gmt":"2014-08-21T00:26:35","guid":{"rendered":"https:\/\/lpfch.org\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/"},"modified":"2024-10-23T16:28:14","modified_gmt":"2024-10-23T16:28:14","slug":"many-minds-one-goal-toward-a-cure-for-childhood-cancer","status":"publish","type":"post","link":"https:\/\/lpfch.org\/vi\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/","title":{"rendered":"Nhi\u1ec1u T\u00e2m Tr\u00ed, M\u1ed9t M\u1ee5c Ti\u00eau: H\u01b0\u1edbng \u0110\u1ebfn Ph\u01b0\u01a1ng Ph\u00e1p Ch\u1eefa Tr\u1ecb Ung Th\u01b0 \u1ede Tr\u1ebb Em"},"content":{"rendered":"

Ung th\u01b0 b\u1eaft \u0111\u1ea7u nh\u01b0 th\u1ebf n\u00e0o? Nh\u00e0 sinh v\u1eadt h\u1ecdc ung th\u01b0 Julien Sage, Ti\u1ebfn s\u0129, t\u1ea1i Stanford \u0111\u00e3 d\u00e0nh ph\u1ea7n l\u1edbn s\u1ef1 nghi\u1ec7p c\u1ee7a m\u00ecnh \u0111\u1ec3 gi\u1ea3i quy\u1ebft c\u00e2u h\u1ecfi c\u01a1 b\u1ea3n \u0111\u00f3.<\/span><\/p>\n

Sage kh\u00f4ng \u0111\u01a1n \u0111\u1ed9c trong n\u1ed7 l\u1ef1c n\u00e0y, nhi\u1ec1u nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i Tr\u01b0\u1eddng Y Stanford c\u0169ng \u0111ang nghi\u00ean c\u1ee9u nguy\u00ean nh\u00e2n v\u00e0 ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb cho nhi\u1ec1u lo\u1ea1i ung th\u01b0 v\u00e0 b\u1ec7nh m\u00e1u \u1edf tr\u1ebb em: b\u1ec7nh b\u1ea1ch c\u1ea7u, u nguy\u00ean b\u00e0o v\u00f5ng m\u1ea1c, u x\u01b0\u01a1ng \u00e1c t\u00ednh v\u00e0 b\u1ec7nh thi\u1ebfu m\u00e1u h\u1ed3ng c\u1ea7u h\u00ecnh li\u1ec1m, c\u00f9ng nhi\u1ec1u b\u1ec7nh kh\u00e1c.<\/p>\n

Nhi\u1ec1u t\u00e2m tr\u00ed<\/h2>\n

Theo Sage, ung th\u01b0 c\u00f3 th\u1ec3 b\u1eaft \u0111\u1ea7u t\u1eeb DNA c\u1ee7a t\u1ebf b\u00e0o g\u1ed1c, c\u00f3 kh\u1ea3 n\u0103ng chuy\u1ec3n h\u00f3a th\u00e0nh t\u1ebf b\u00e0o m\u00e1u, gan, n\u00e3o v\u00e0 c\u00e1c t\u1ebf b\u00e0o tr\u01b0\u1edfng th\u00e0nh kh\u00e1c \u2013 m\u1ed9t qu\u00e1 tr\u00ecnh g\u1ecdi l\u00e0 bi\u1ec7t h\u00f3a.<\/p>\n

\u201cT\u1ebf b\u00e0o g\u1ed1c b\u00ecnh th\u01b0\u1eddng ph\u00e2n chia th\u00e0nh c\u00e1c t\u1ebf b\u00e0o bi\u1ec7t h\u00f3a c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 s\u1eeda ch\u1eefa v\u00e0 duy tr\u00ec m\u00f4,\u201d Sage, ph\u00f3 gi\u00e1o s\u01b0 sinh h\u1ecdc ung th\u01b0 nhi khoa v\u00e0 di truy\u1ec1n h\u1ecdc, \u0111\u1ed3ng th\u1eddi l\u00e0 H\u1ecdc gi\u1ea3 Khoa Y h\u1ecdc Chuy\u1ec3n d\u1ecbch Nhi khoa Tashia v\u00e0 John Morgridge, gi\u1ea3i th\u00edch. \u201cNh\u01b0ng trong ung th\u01b0, t\u1ebf b\u00e0o g\u1ed1c \u0111\u1ed9t bi\u1ebfn v\u00e0 ph\u00e2n chia kh\u00f4ng ki\u1ec3m so\u00e1t. Thay v\u00ec t\u1ea1o ra m\u00f4 b\u00ecnh th\u01b0\u1eddng, c\u00e1c t\u1ebf b\u00e0o b\u1eaft \u0111\u1ea7u t\u1ea1o ra kh\u1ed1i u. Ch\u00fang t\u00f4i quan t\u00e2m \u0111\u1ebfn vi\u1ec7c t\u00ecm hi\u1ec3u s\u1ef1 c\u00e2n b\u1eb1ng tinh t\u1ebf gi\u1eefa qu\u00e1 tr\u00ecnh t\u00e1i t\u1ea1o t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng v\u00e0 s\u1ef1 t\u0103ng sinh b\u1ea5t th\u01b0\u1eddng c\u1ee7a ung th\u01b0.\u201d<\/p>\n

Sage \u0111ang nghi\u00ean c\u1ee9u c\u00e1c gen g\u00e2y ra b\u1ec7nh u nguy\u00ean b\u00e0o v\u00f5ng m\u1ea1c, d\u1ea1ng ung th\u01b0 m\u1eaft ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf tr\u1ebb em. Ch\u00edn trong s\u1ed1 10 tr\u1ebb em \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n m\u1eafc b\u1ec7nh n\u00e0y \u1edf Hoa K\u1ef3 \u0111\u1ec1u \u0111\u01b0\u1ee3c ch\u1eefa kh\u1ecfi, m\u1eb7c d\u00f9 t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t th\u1ea5p h\u01a1n nhi\u1ec1u \u1edf c\u00e1c n\u01b0\u1edbc \u0111ang ph\u00e1t tri\u1ec3n.<\/p>\n

U nguy\u00ean b\u00e0o v\u00f5ng m\u1ea1c l\u00e0 do \u0111\u1ed9t bi\u1ebfn gen RB. Sage g\u1ea7n \u0111\u00e2y \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng khi gen RB v\u00e0 c\u00e1c th\u00e0nh vi\u00ean c\u00f9ng h\u1ecd b\u1ecb b\u1ea5t ho\u1ea1t, c\u00e1c t\u1ebf b\u00e0o g\u1ed1c trong gan s\u1ebd nh\u00e2n l\u00ean nhanh ch\u00f3ng v\u00e0 ph\u00e1t tri\u1ec3n th\u00e0nh m\u1ed9t kh\u1ed1i u ch\u1ebft ng\u01b0\u1eddi g\u1ecdi l\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o gan (HCC). Tuy nhi\u00ean, \u00f4ng c\u0169ng ph\u00e1t hi\u1ec7n ra r\u1eb1ng m\u1ed9t con \u0111\u01b0\u1eddng truy\u1ec1n t\u00edn hi\u1ec7u \u0111\u1eb7c hi\u1ec7u g\u1ecdi l\u00e0 Notch th\u1ef1c s\u1ef1 c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a kh\u1ed1i u. V\u1ec1 b\u1ea3n ch\u1ea5t, m\u1ee9c \u0111\u1ed9 ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Notch c\u00f3 th\u1ec3 gi\u00fap d\u1ef1 \u0111o\u00e1n kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t c\u1ee7a b\u1ec7nh nh\u00e2n HCC.<\/p>\n

Sage gi\u1ea3i th\u00edch: \u201cVi\u1ec7c hi\u1ec3u \u0111\u01b0\u1ee3c con \u0111\u01b0\u1eddng Notch c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi cho kh\u1ed1i u \u1edf tr\u1ebb em\u201d.<\/p>\n

Nhi\u1ec1u t\u00e2m tr\u00ed<\/h2>\n

Sage hi\u1ec7n \u0111ang ki\u1ec3m tra c\u00e1c m\u1eabu m\u00f4 t\u1eeb t\u00e1m b\u1ec7nh nh\u00e2n m\u1eafc m\u1ed9t d\u1ea1ng ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o gan hi\u1ebfm g\u1eb7p \u1edf tr\u1ebb em, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 ung th\u01b0 bi\u1ec3u m\u00f4 s\u1ee3i phi\u1ebfn. \u00d4ng v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p t\u1ea1i Trung t\u00e2m C\u00f4ng ngh\u1ec7 B\u1ed9 gen Stanford \u0111\u00e3 b\u1eaft \u0111\u1ea7u c\u00f4ng vi\u1ec7c kh\u00f3 kh\u0103n l\u00e0 so s\u00e1nh DNA trong c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u v\u1edbi DNA t\u1eeb gan kh\u1ecfe m\u1ea1nh.<\/p>\n

"Ch\u00fang t\u00f4i hy v\u1ecdng t\u00ecm ra lo\u1ea1i \u0111\u1ed9t bi\u1ebfn n\u00e0o ch\u00fang m\u1eafc ph\u1ea3i, ch\u00fang b\u1eaft \u0111\u1ea7u nh\u01b0 th\u1ebf n\u00e0o v\u00e0 t\u1ea1i sao ch\u00fang l\u1ea1i hi\u1ebfm \u0111\u1ebfn v\u1eady", Sage n\u00f3i. "Ki\u1ebfn th\u1ee9c \u0111\u00f3 c\u00f3 th\u1ec3 gi\u00fap ch\u00fang t\u00f4i hi\u1ec3u \u0111\u01b0\u1ee3c c\u00e1c c\u01a1 ch\u1ebf c\u01a1 b\u1ea3n kh\u1edfi ph\u00e1t c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c \u1edf tr\u1ebb em."<\/p>\n

Nghi\u00ean c\u1ee9u v\u1ec1 ung th\u01b0 bi\u1ec3u m\u00f4 s\u1ee3i l\u00e0 n\u1ed7 l\u1ef1c \u0111a ng\u00e0nh tr\u00ean to\u00e0n khu\u00f4n vi\u00ean tr\u01b0\u1eddng, bao g\u1ed3m nh\u00f3m gh\u00e9p gan t\u1ea1i B\u1ec7nh vi\u1ec7n nhi Packard, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u b\u1ec7nh h\u1ecdc, nh\u00e0 ph\u00e2n t\u00edch DNA v\u00e0 nhi\u1ec1u chuy\u00ean gia kh\u00e1c.<\/p>\n

"Ch\u00fang t\u00f4i mu\u1ed1n th\u1ef1c hi\u1ec7n gi\u1ea3i tr\u00ecnh t\u1ef1 v\u00e0 ph\u00e2n t\u00edch theo th\u1eddi gian th\u1ef1c \u0111\u1ee7 nhanh \u0111\u1ec3 c\u00f3 th\u1ec3 th\u1ef1c s\u1ef1 gi\u00fap \u0111\u1ee1 b\u1ec7nh nh\u00e2n", Sage n\u00f3i. "Hi\u1ec7n t\u1ea1i, qu\u00e1 tr\u00ecnh \u0111\u00f3 m\u1ea5t s\u00e1u th\u00e1ng ho\u1eb7c h\u01a1n. Ch\u00fang t\u00f4i kh\u00f4ng th\u1ec3 m\u1eafc sai l\u1ea7m v\u00e0 ch\u1ea9n \u0111o\u00e1n sai b\u1ec7nh ung th\u01b0."<\/p>\n

Y h\u1ecdc c\u00e1 nh\u00e2n h\u00f3a<\/h2>\n

Lo\u1ea1i h\u00ecnh nghi\u00ean c\u1ee9u h\u1ee3p t\u00e1c n\u00e0y l\u00e0 \u0111i\u1ec3m \u0111\u1eb7c tr\u01b0ng c\u1ee7a ch\u01b0\u01a1ng tr\u00ecnh Sinh h\u1ecdc Ung th\u01b0 Nhi khoa t\u1ea1i Stanford. D\u01b0\u1edbi s\u1ef1 ch\u1ec9 \u0111\u1ea1o c\u1ee7a Ti\u1ebfn s\u0129 Michael Cleary, Gi\u00e1o s\u01b0 Gia \u0111\u00ecnh Lindhard v\u1ec1 Sinh h\u1ecdc Ung th\u01b0 Nhi khoa, Sage v\u00e0 c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u kh\u00e1c \u0111ang ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb nh\u1eafm m\u1ee5c ti\u00eau ph\u00f9 h\u1ee3p v\u1edbi t\u1eebng b\u1ec7nh nh\u00e2n - m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 y h\u1ecdc c\u00e1 nh\u00e2n h\u00f3a.<\/p>\n

Nhi\u1ec1u t\u00e2m tr\u00ed<\/h2>\n

Trong s\u1ed1 nh\u00f3m nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 Matthew Porteus, Ti\u1ebfn s\u0129, Ti\u1ebfn s\u0129, ph\u00f3 gi\u00e1o s\u01b0 nhi khoa, ng\u01b0\u1eddi \u0111ang ph\u00e1t tri\u1ec3n m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p m\u1edbi cho li\u1ec7u ph\u00e1p gen.<\/p>\n

\u201cPh\u01b0\u01a1ng ph\u00e1p truy\u1ec1n th\u1ed1ng l\u00e0 s\u1eed d\u1ee5ng virus bi\u1ebfn \u0111\u1ed5i gen \u0111\u1ec3 \u0111\u01b0a phi\u00ean b\u1ea3n kh\u1ecfe m\u1ea1nh c\u1ee7a m\u1ed9t gen b\u1ecb t\u1ed5n th\u01b0\u01a1ng v\u00e0o DNA c\u1ee7a b\u1ec7nh nh\u00e2n,\u201d Porteus n\u00f3i. \u201cC\u00e1ch n\u00e0y hi\u1ec7u qu\u1ea3 v\u1edbi m\u1ed9t s\u1ed1 b\u1ec7nh nh\u1ea5t \u0111\u1ecbnh, nh\u01b0ng \u0111i\u1ec1u \u0111\u00e1ng lo ng\u1ea1i l\u00e0 b\u1ea1n kh\u00f4ng th\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c v\u1ecb tr\u00ed virus x\u00e2m nh\u1eadp v\u00e0o b\u1ed9 gen. \u0110\u00f4i khi, n\u00f3 k\u00edch ho\u1ea1t c\u00e1c gen b\u00ecnh th\u01b0\u1eddng, khi\u1ebfn t\u1ebf b\u00e0o tr\u1edf th\u00e0nh t\u1ebf b\u00e0o ung th\u01b0.\u201d<\/p>\n

Thay v\u00ec s\u1eed d\u1ee5ng virus, Porteus \u0111ang kh\u00e1m ph\u00e1 ph\u01b0\u01a1ng ph\u00e1p "c\u1eaft v\u00e0 d\u00e1n" trong li\u1ec7u ph\u00e1p gen. B\u01b0\u1edbc \u0111\u1ea7u ti\u00ean l\u00e0 tr\u00edch xu\u1ea5t t\u1ebf b\u00e0o g\u1ed1c b\u1ecb b\u1ec7nh t\u1eeb b\u1ec7nh nh\u00e2n. Ti\u1ebfp theo, \u00f4ng ti\u00eam v\u00e0o DNA c\u1ee7a t\u1ebf b\u00e0o c\u00e1c protein \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf \u0111\u1ec3 nh\u1eadn di\u1ec7n gen \u0111\u1ed9t bi\u1ebfn, chia \u0111\u00f4i n\u00f3, sau \u0111\u00f3 s\u1eeda l\u1ed7i \u0111\u1ed9t bi\u1ebfn v\u00e0 d\u00e1n l\u1ea1i DNA kh\u1ecfe m\u1ea1nh. Porteus v\u00e0 nh\u00f3m c\u1ee7a \u00f4ng hi\u1ec7n \u0111ang t\u1eadp trung v\u00e0o vi\u1ec7c s\u1eeda ch\u1eefa gen g\u00e2y b\u1ec7nh thi\u1ebfu m\u00e1u h\u1ed3ng c\u1ea7u h\u00ecnh li\u1ec1m, nh\u01b0ng k\u1ef9 thu\u1eadt n\u00e0y c\u00f3 th\u1ec3 \u00e1p d\u1ee5ng cho c\u00e1c b\u1ec7nh di truy\u1ec1n kh\u00e1c.<\/p>\n

G\u1ea7n \u0111\u00e2y, Porteus \u0111\u00e3 \u0111\u01b0\u1ee3c vinh danh l\u00e0 H\u1ecdc gi\u1ea3 Khoa Laurie Kraus Lacob. Gi\u1ea3i th\u01b0\u1edfng n\u0103m n\u0103m n\u00e0y h\u1ed7 tr\u1ee3 nh\u00e2n s\u1ef1 v\u00e0 c\u00e1c d\u1ef1 \u00e1n trong ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a \u00f4ng. "S\u1ef1 h\u1ed7 tr\u1ee3 t\u00e0i ch\u00ednh nh\u01b0 gi\u1ea3i th\u01b0\u1edfng Lacob r\u1ea5t quan tr\u1ecdng, b\u1edfi v\u00ec lo\u1ea1i h\u00ecnh nghi\u00ean c\u1ee9u n\u00e0y kh\u00f4ng th\u1ec3 th\u1ef1c hi\u1ec7n m\u1ed9t s\u1edbm m\u1ed9t chi\u1ec1u", \u00f4ng n\u00f3i. "\u0110\u00f3 l\u00e0 m\u1ed9t cam k\u1ebft d\u00e0i h\u1ea1n, cung c\u1ea5p th\u1eddi gian v\u00e0 ngu\u1ed3n l\u1ef1c c\u1ea7n thi\u1ebft \u0111\u1ec3 ch\u00fang t\u00f4i \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng ti\u1ebfn b\u1ed9 r\u00f5 r\u1ec7t."
\nH\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch \u0111\u01b0\u1ee3c x\u00e2y d\u1ef1ng l\u1ea1i<\/p>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ea1i Stanford c\u0169ng \u0111ang nghi\u00ean c\u1ee9u nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p m\u1edbi \u0111\u1ec3 c\u1ea3i thi\u1ec7n li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 nhi khoa b\u1eb1ng c\u00e1ch s\u1eed d\u1ee5ng t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n \u2013 giai \u0111o\u1ea1n trung gian gi\u1eefa t\u1ebf b\u00e0o g\u1ed1c v\u00e0 t\u1ebf b\u00e0o tr\u01b0\u1edfng th\u00e0nh.<\/p>\n

Ti\u1ebfn s\u0129 Kenneth Weinberg \u0111ang nghi\u00ean c\u1ee9u m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o m\u1edbi \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n c\u00f3 t\u00ean l\u00e0 ti\u1ec1n th\u00e2n commonmphoid (CLP), t\u1ebf b\u00e0o g\u1ed1c c\u1ee7a t\u1ebf b\u00e0o t\u1ee7y x\u01b0\u01a1ng. CLP s\u1ea3n sinh ra t\u1ebf b\u00e0o lympho - t\u1ebf b\u00e0o b\u1ea1ch c\u1ea7u ch\u1ed1ng nhi\u1ec5m tr\u00f9ng - v\u00e0 c\u00f3 th\u1ec3 gi\u00fap t\u0103ng c\u01b0\u1eddng kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch cho tr\u1ebb em \u0111\u00e3 \u0111\u01b0\u1ee3c gh\u00e9p t\u1ee7y x\u01b0\u01a1ng.<\/p>\n

Nhi\u1ec1u b\u1ec7nh nh\u00e2n ung th\u01b0 m\u00e1u \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi h\u00f3a tr\u1ecb, ph\u01b0\u01a1ng ph\u00e1p n\u00e0y ti\u00eau di\u1ec7t t\u1ebf b\u00e0o m\u00e1u ung th\u01b0 b\u1eb1ng c\u00e1ch ph\u00e1 h\u1ee7y t\u1ee7y x\u01b0\u01a1ng. Tr\u1ebb em kh\u00f4ng dung n\u1ea1p \u0111\u01b0\u1ee3c li\u1ec1u h\u00f3a tr\u1ecb cao \u0111\u00f4i khi \u0111\u01b0\u1ee3c gh\u00e9p t\u1ee7y x\u01b0\u01a1ng sau \u0111\u00f3 \u0111\u1ec3 t\u00e1i t\u1ea1o h\u1ec7 mi\u1ec5n d\u1ecbch.<\/p>\n

Weinberg, Gi\u00e1o s\u01b0 Anne T. v\u00e0 Robert M. Bass v\u1ec1 Ung th\u01b0 Nhi khoa v\u00e0 B\u1ec7nh m\u00e1u, \u0111\u1eb7t c\u00e2u h\u1ecfi: "C\u00e2u h\u1ecfi \u0111\u1eb7t ra l\u00e0 l\u00e0m th\u1ebf n\u00e0o ch\u00fang ta c\u00f3 th\u1ec3 t\u0103ng c\u01b0\u1eddng h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch m\u1edbi \u0111\u1ec3 n\u00f3 ph\u1ee5c h\u1ed3i nhanh h\u01a1n v\u00e0 ki\u1ec3m so\u00e1t b\u1ec7nh ung th\u01b0 nhanh h\u01a1n?"<\/p>\n

Th\u00f4ng th\u01b0\u1eddng, ph\u1ea3i m\u1ea5t t\u1eeb s\u00e1u th\u00e1ng \u0111\u1ebfn m\u1ed9t n\u0103m sau khi gh\u00e9p t\u1ee7y x\u01b0\u01a1ng \u0111\u1ec3 h\u1ec7 mi\u1ec5n d\u1ecbch m\u1edbi ph\u00e1t tri\u1ec3n. Tuy nhi\u00ean, c\u00e1c nghi\u00ean c\u1ee9u do Weinberg v\u00e0 c\u1ed9ng s\u1ef1 th\u1ef1c hi\u1ec7n cho th\u1ea5y vi\u1ec7c k\u1ebft h\u1ee3p CLP v\u00e0 y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng interleukin-7 c\u00f3 th\u1ec3 t\u1ea1o ra m\u1ed9t h\u1ec7 mi\u1ec5n d\u1ecbch m\u1edbi ch\u1ec9 t\u1eeb ba \u0111\u1ebfn s\u00e1u tu\u1ea7n sau khi gh\u00e9p.<\/p>\n

Weinberg gi\u1ea3i th\u00edch: "H\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch c\u1ee7a b\u1ea1n ph\u00e1t tri\u1ec3n c\u00e0ng nhanh th\u00ec kh\u1ea3 n\u0103ng b\u1ec7nh b\u1ea1ch c\u1ea7u t\u00e1i ph\u00e1t c\u00e0ng th\u1ea5p".<\/p>\n

\u201cM\u1ed9t v\u1ea5n \u0111\u1ec1 kh\u00e1c v\u1edbi gh\u00e9p t\u1ea1ng v\u00e0 h\u00f3a tr\u1ecb l\u00e0 b\u1ec7nh nh\u00e2n c\u00f3 nguy c\u01a1 nhi\u1ec5m tr\u00f9ng cao. Trong ph\u00f2ng th\u00ed nghi\u1ec7m, ch\u00fang t\u00f4i ph\u00e1t hi\u1ec7n ra r\u1eb1ng CLP v\u1ec1 c\u01a1 b\u1ea3n c\u00f3 th\u1ec3 ng\u0103n ng\u1eeba nhi\u1ec5m tr\u00f9ng.\u201d<\/p>\n

Weinberg v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u0111ang l\u00ean k\u1ebf ho\u1ea1ch cho m\u1ed9t nghi\u00ean c\u1ee9u th\u00ed \u0111i\u1ec3m v\u00e0o n\u0103m t\u1edbi \u0111\u1ec3 ki\u1ec3m tra hi\u1ec7u qu\u1ea3 c\u1ee7a CLP \u1edf b\u1ec7nh nh\u00e2n ung th\u01b0. H\u1ecd hy v\u1ecdng s\u1ebd tuy\u1ec3n \u0111\u01b0\u1ee3c hai m\u01b0\u01a1i tr\u1ebb em b\u1ecb b\u1ec7nh b\u1ea1ch c\u1ea7u t\u00e1i ph\u00e1t sau h\u00f3a tr\u1ecb. Tuy nhi\u00ean, Weinberg cho bi\u1ebft c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng r\u1ea5t t\u1ed1n k\u00e9m, v\u00e0 vi\u1ec7c nh\u1eadn \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 t\u1eeb Vi\u1ec7n Y t\u1ebf Qu\u1ed1c gia (NIH), m\u1ed9t ngu\u1ed3n t\u00e0i tr\u1ee3 truy\u1ec1n th\u1ed1ng, \u0111\u00e3 tr\u1edf n\u00ean c\u1ef1c k\u1ef3 c\u1ea1nh tranh.<\/p>\n

\u201cC\u00e1c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng m\u00e0 ch\u00fang t\u00f4i th\u1ef1c hi\u1ec7n t\u1ea1i Packard l\u00e0 m\u1ed9t trong nh\u1eefng nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean thu\u1ed9c lo\u1ea1i n\u00e0y,\u201d Weinberg n\u00f3i, \u201cnh\u01b0ng c\u00e1i th\u1eddi ch\u00fang t\u00f4i ch\u1ec9 c\u00f3 th\u1ec3 d\u1ef1a v\u00e0o ngu\u1ed3n t\u00e0i tr\u1ee3 c\u1ee7a NIH \u0111\u00e3 qua l\u00e2u r\u1ed3i. Ch\u00fang t\u00f4i ng\u00e0y c\u00e0ng ph\u1ee5 thu\u1ed9c v\u00e0o ho\u1ea1t \u0111\u1ed9ng t\u1eeb thi\u1ec7n \u0111\u1ec3 duy tr\u00ec t\u00ednh li\u00ean t\u1ee5c cho nghi\u00ean c\u1ee9u c\u1ee7a m\u00ecnh.\u201d<\/p>\n

T\u00ecm g\u00f3t ch\u00e2n Achilles<\/h2>\n

U sarcoma Ewing v\u00e0 u sarcoma x\u01b0\u01a1ng, hai lo\u1ea1i ung th\u01b0 x\u01b0\u01a1ng ph\u1ed5 bi\u1ebfn nh\u1ea5t \u1edf tr\u1ebb em, c\u00f3 t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t l\u00ean \u0111\u1ebfn 70% n\u1ebfu \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n s\u1edbm. \u0110\u00e1ng ti\u1ebfc l\u00e0, khi nhi\u1ec1u b\u1ec7nh nh\u00e2n tr\u1ebb \u0111\u1ebfn B\u1ec7nh vi\u1ec7n Nhi Packard \u0111\u1ec3 ch\u1ea9n \u0111o\u00e1n, kh\u1ed1i u \u0111\u00e3 di c\u0103n.<\/p>\n

"Nh\u1eefng \u0111\u1ee9a tr\u1ebb \u0111\u00f3 ch\u1ec9 c\u00f3 20% c\u01a1 h\u1ed9i s\u1ed1ng s\u00f3t", Ti\u1ebfn s\u0129 Alejandro Sweet-Cordero, ph\u00f3 gi\u00e1o s\u01b0 khoa sinh h\u1ecdc ung th\u01b0 nhi khoa, cho bi\u1ebft. "Ch\u00fang t\u00f4i \u0111ang c\u1ed1 g\u1eafng t\u00ecm hi\u1ec3u s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa kh\u1ed1i u x\u01b0\u01a1ng di c\u0103n v\u00e0 kh\u1ed1i u kh\u00f4ng di c\u0103n. C\u00e0ng hi\u1ec3u r\u00f5 v\u1ec1 \u0111\u1eb7c \u0111i\u1ec3m sinh h\u1ecdc c\u1ee7a kh\u1ed1i u, ch\u00fang t\u00f4i c\u00e0ng c\u00f3 kh\u1ea3 n\u0103ng x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c \u0111i\u1ec3m y\u1ebfu c\u1ee7a n\u00f3 v\u00e0 k\u00ea \u0111\u01a1n thu\u1ed1c \u0111\u1ec3 ng\u0103n ch\u1eb7n n\u00f3."<\/p>\n

U sarcoma Ewing v\u00e0 u sarcoma x\u01b0\u01a1ng l\u00e0 do \u0111\u1ed9t bi\u1ebfn DNA x\u1ea3y ra sau khi tr\u1ebb ch\u00e0o \u0111\u1eddi. "Tuy nhi\u00ean, m\u1eb7c d\u00f9 ch\u00fang ta hi\u1ec3u \u0111\u01b0\u1ee3c nguy\u00ean nh\u00e2n ph\u00e2n t\u1eed c\u1ee7a c\u0103n b\u1ec7nh n\u00e0y, ch\u00fang ta v\u1eabn ch\u01b0a bi\u1ebft t\u1ea1i sao n\u00f3 l\u1ea1i x\u1ea3y ra \u1edf m\u1ed9t s\u1ed1 ng\u01b0\u1eddi m\u00e0 kh\u00f4ng x\u1ea3y ra \u1edf nh\u1eefng ng\u01b0\u1eddi kh\u00e1c", Sweet-Cordero, \u0111\u1ed3ng th\u1eddi l\u00e0 H\u1ecdc gi\u1ea3 Khoa Y h\u1ecdc Chuy\u1ec3n d\u1ecbch Nhi khoa c\u1ee7a Tashia v\u00e0 John Morgridge, gi\u1ea3i th\u00edch.<\/p>\n

\u0110\u1ec3 gi\u00fap gi\u1ea3i quy\u1ebft b\u00e0i to\u00e1n di truy\u1ec1n n\u00e0y, Sweet-Cordero \u0111\u00e3 chuy\u1ec3n sang s\u1eed d\u1ee5ng c\u01a1 s\u1edf gi\u1ea3i tr\u00ecnh t\u1ef1 DNA th\u00f4ng l\u01b0\u1ee3ng cao t\u1ea1i Stanford. "C\u00f4ng ngh\u1ec7 n\u00e0y c\u00f3 th\u1ec3 ch\u1ee5p \u1ea3nh to\u00e0n b\u1ed9 kh\u1ed1i u v\u00e0 xem x\u00e9t t\u1ea5t c\u1ea3 nh\u1eefng thay \u0111\u1ed5i \u0111ang di\u1ec5n ra trong t\u1ea5t c\u1ea3 c\u00e1c gen c\u00f9ng m\u1ed9t l\u00fac", \u00f4ng n\u00f3i. "N\u00f3 gi\u00fap ch\u00fang t\u00f4i x\u00e1c \u0111\u1ecbnh c\u00e1c s\u1ef1 ki\u1ec7n di truy\u1ec1n trong kh\u1ed1i u v\u00e0 li\u00ean h\u1ec7 ch\u00fang v\u1edbi di\u1ec5n bi\u1ebfn c\u1ee7a b\u1ec7nh ho\u1eb7c c\u00e1ch b\u1ec7nh nh\u00e2n \u0111\u00e1p \u1ee9ng v\u1edbi li\u1ec7u ph\u00e1p \u0111i\u1ec1u tr\u1ecb."<\/p>\n

Sweet-Cordero c\u0169ng \u0111ang h\u1ee3p t\u00e1c v\u1edbi c\u00e1c \u0111\u1ed3ng nghi\u1ec7p t\u1ea1i Vi\u1ec7n Sinh h\u1ecdc T\u1ebf b\u00e0o g\u1ed1c v\u00e0 Y h\u1ecdc t\u00e1i t\u1ea1o Stanford \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh xem c\u00f3 lo\u1ea1i t\u1ebf b\u00e0o c\u1ee5 th\u1ec3 n\u00e0o c\u00f3 nhi\u1ec5m s\u1eafc th\u1ec3 \u0111\u1eb7c bi\u1ec7t d\u1ec5 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi c\u00e1c s\u1ef1 ki\u1ec7n di truy\u1ec1n c\u1ee5 th\u1ec3 g\u00e2y ra ung th\u01b0 hay kh\u00f4ng.<\/p>\n

"N\u1ebfu ch\u00fang ta c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c lo\u1ea1i t\u1ebf b\u00e0o \u0111\u00f3, c\u00f3 th\u1ec3 s\u1ebd c\u00f3 c\u01a1 h\u1ed9i cho c\u00e1c li\u1ec7u ph\u00e1p t\u1ed1t h\u01a1n", \u00f4ng n\u00f3i. "\u0110i\u1ec1u \u0111\u00f3 r\u1ea5t th\u00fa v\u1ecb. Ch\u00fang ta \u0111ang \u1edf giai \u0111o\u1ea1n \u0111\u1ea7u c\u1ee7a m\u1ed9t cu\u1ed9c c\u00e1ch m\u1ea1ng trong c\u00e1ch \u0111i\u1ec1u tr\u1ecb t\u1eebng b\u1ec7nh nh\u00e2n."<\/p>\n

\u0110\u00e3 ch\u1eefa kh\u1ecfi 100 ph\u1ea7n tr\u0103m<\/h2>\n

Khi Kathleen Sakamoto, Ti\u1ebfn s\u0129, B\u00e1c s\u0129 Y khoa, c\u00f2n h\u1ecdc tr\u01b0\u1eddng y c\u00e1ch \u0111\u00e2y 30 n\u0103m, ti\u00ean l\u01b0\u1ee3ng cho tr\u1ebb em m\u1eafc b\u1ec7nh b\u1ea1ch c\u1ea7u t\u1ee7y c\u1ea5p t\u00ednh (AML) r\u1ea5t \u1ea3m \u0111\u1ea1m.<\/p>\n

\u201cH\u1ed3i \u0111\u00f3, ch\u01b0a \u0111\u1ebfn 20% b\u1ec7nh nhi m\u1eafc AML s\u1ed1ng s\u00f3t,\u201d Sakamoto n\u00f3i. \u201cNg\u00e0y nay, t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t chung l\u00e0 kho\u1ea3ng 50%, v\u1eabn kh\u00f4ng th\u1ec3 ch\u1ea5p nh\u1eadn \u0111\u01b0\u1ee3c. M\u1ee5c ti\u00eau c\u1ee7a ch\u00fang t\u00f4i l\u00e0 ch\u1eefa kh\u1ecfi 100% tr\u1ebb em m\u1eafc AML.\u201d<\/p>\n

L\u00e0 m\u1ed9t chuy\u00ean gia \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn r\u1ed9ng r\u00e3i v\u1ec1 b\u1ec7nh AML v\u00e0 c\u00e1c b\u1ec7nh v\u1ec1 m\u00e1u kh\u00e1c, Sakamoto g\u1ea7n \u0111\u00e2y \u0111\u00e3 \u0111\u01b0\u1ee3c b\u1ed5 nhi\u1ec7m l\u00e0m tr\u01b0\u1edfng khoa Huy\u1ebft h\u1ecdc nhi khoa, Ung th\u01b0, C\u1ea5y gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c v\u00e0 Sinh h\u1ecdc ung th\u01b0 t\u1ea1i Stanford.<\/p>\n

M\u1ed7i n\u0103m, c\u00f3 kho\u1ea3ng 10 b\u1ec7nh nh\u00e2n t\u1ea1i B\u1ec7nh vi\u1ec7n Nhi Packard \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb AML, m\u1ed9t lo\u1ea1i ung th\u01b0 \u00e1c t\u00ednh t\u01b0\u01a1ng \u0111\u1ed1i ph\u1ed5 bi\u1ebfn \u2013 v\u00e0 th\u01b0\u1eddng g\u00e2y t\u1eed vong \u2013 \u1edf ng\u01b0\u1eddi l\u1edbn nh\u01b0ng hi\u1ebfm g\u1eb7p \u1edf tr\u1ebb em. AML khi\u1ebfn t\u1ee7y x\u01b0\u01a1ng s\u1ea3n sinh ra m\u1ed9t l\u01b0\u1ee3ng l\u1edbn t\u1ebf b\u00e0o m\u00e1u b\u1ea5t th\u01b0\u1eddng, c\u00f3 th\u1ec3 x\u00e2m l\u1ea5n n\u00e3o, l\u00e1 l\u00e1ch v\u00e0 c\u00e1c c\u01a1 quan kh\u00e1c.<\/p>\n

Nguy\u00ean nh\u00e2n g\u00e2y ra AML v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5, nh\u01b0ng Sakamoto v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 t\u00ecm ra m\u1ed9t manh m\u1ed1i quan tr\u1ecdng. "Ch\u00fang t\u00f4i \u0111ang n\u1ed7 l\u1ef1c t\u00ecm hi\u1ec3u c\u00e1c t\u00edn hi\u1ec7u b\u00e1o hi\u1ec7u t\u1ebf b\u00e0o ph\u00e2n chia, tr\u01b0\u1edfng th\u00e0nh ho\u1eb7c tr\u1ea3i qua qu\u00e1 tr\u00ecnh ch\u1ebft t\u1ebf b\u00e0o theo ch\u01b0\u01a1ng tr\u00ecnh", b\u00e0 n\u00f3i. "Kho\u1ea3ng m\u1ed9t th\u1eadp k\u1ef7 tr\u01b0\u1edbc, ch\u00fang t\u00f4i \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c m\u1ed9t lo\u1ea1i protein g\u1ecdi l\u00e0 CREB, \u0111\u01b0\u1ee3c s\u1ea3n xu\u1ea5t qu\u00e1 m\u1ee9c trong t\u1ebf b\u00e0o t\u1ee7y x\u01b0\u01a1ng \u1edf b\u1ec7nh nh\u00e2n AML. CREB l\u00e0 m\u1ed9t protein b\u00ecnh th\u01b0\u1eddng gi\u00fap t\u1ebf b\u00e0o ph\u00e1t tri\u1ec3n, nh\u01b0ng khi c\u00f3 qu\u00e1 nhi\u1ec1u, n\u00f3 s\u1ebd g\u00e2y ra s\u1ef1 ph\u00e1t tri\u1ec3n qu\u00e1 m\u1ee9c v\u00e0 c\u00f3 th\u1ec3 tr\u1edf th\u00e0nh ung th\u01b0."<\/p>\n

M\u1ee5c ti\u00eau c\u1ee7a Sakamoto l\u00e0 ph\u00e1t tri\u1ec3n m\u1ed9t lo\u1ea1i thu\u1ed1c cho tr\u1ebb em m\u1eafc AML, \u1ee9c ch\u1ebf ch\u1ee9c n\u0103ng c\u1ee7a CREB m\u00e0 kh\u00f4ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn c\u00e1c t\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng. M\u1ed9t h\u1ee3p ch\u1ea5t \u0111\u00e3 cho th\u1ea5y k\u1ebft qu\u1ea3 kh\u1ea3 quan, nh\u01b0ng vi\u1ec7c \u0111\u01b0a n\u00f3 t\u1eeb ph\u00f2ng th\u00ed nghi\u1ec7m \u0111\u1ebfn gi\u01b0\u1eddng b\u1ec7nh nh\u00e2n s\u1ebd m\u1ea5t nhi\u1ec1u n\u0103m nghi\u00ean c\u1ee9u v\u00e0 th\u1eed nghi\u1ec7m h\u01a1n. \u0110\u1ed1i v\u1edbi Sakamoto, vi\u1ec7c h\u1ecdc t\u1eadp t\u1ea1i Stanford \u0111\u00e3 gi\u00fap qu\u00e1 tr\u00ecnh n\u00e0y b\u1edbt kh\u00f3 kh\u0103n h\u01a1n r\u1ea5t nhi\u1ec1u.<\/p>\n

\u201cCh\u00fang t\u00f4i v\u00f4 c\u00f9ng may m\u1eafn khi c\u00f3 m\u1ed9t b\u1ec7nh vi\u1ec7n nhi, tr\u01b0\u1eddng y, b\u1ec7nh vi\u1ec7n ng\u01b0\u1eddi l\u1edbn v\u00e0 tr\u01b0\u1eddng \u0111\u1ea1i h\u1ecdc h\u00e0ng \u0111\u1ea7u, t\u1ea5t c\u1ea3 \u0111\u1ec1u n\u1eb1m trong m\u1ed9t khu\u00f4n vi\u00ean t\u1ea1i trung t\u00e2m Thung l\u0169ng Silicon, th\u1ee7 ph\u1ee7 c\u00f4ng ngh\u1ec7 sinh h\u1ecdc c\u1ee7a th\u1ebf gi\u1edbi,\u201d b\u00e0 n\u00f3i. \u201cN\u1ec1n v\u0103n h\u00f3a \u0111\u1ed5i m\u1edbi c\u00f4ng ngh\u1ec7 v\u00e0 khoa h\u1ecdc ti\u00ean ti\u1ebfn n\u00e0y s\u1ebd d\u1eabn \u0111\u1ebfn nh\u1eefng ti\u1ebfn b\u1ed9 y h\u1ecdc quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u1edf tr\u1ebb em.\u201d<\/p>","protected":false},"excerpt":{"rendered":"

Ung th\u01b0 b\u1eaft \u0111\u1ea7u nh\u01b0 th\u1ebf n\u00e0o? Nh\u00e0 sinh h\u1ecdc ung th\u01b0 Julien Sage, Ti\u1ebfn s\u0129, t\u1ea1i \u0110\u1ea1i h\u1ecdc Stanford, \u0111\u00e3 d\u00e0nh ph\u1ea7n l\u1edbn s\u1ef1 nghi\u1ec7p c\u1ee7a m\u00ecnh \u0111\u1ec3 gi\u1ea3i quy\u1ebft c\u00e2u h\u1ecfi c\u01a1 b\u1ea3n \u0111\u00f3. Sage kh\u00f4ng ph\u1ea3i l\u00e0 ng\u01b0\u1eddi duy nh\u1ea5t\u2026<\/p>","protected":false},"author":17,"featured_media":3556,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[148],"class_list":["post-3555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-the-news","health_topic-pediatric-cancer"],"acf":[],"yoast_head":"\nMany Minds, One Goal: Toward a Cure for Childhood Cancer - Lucile Packard Foundation for Children's Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/lpfch.org\/vi\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Many Minds, One Goal: Toward a Cure for Childhood Cancer\" \/>\n<meta property=\"og:description\" content=\"How does cancer start? Stanford cancer biologist Julien Sage, PhD, has spent much of his career tackling that fundamental question. Sage is not alone in...\" \/>\n<meta property=\"og:url\" content=\"http:\/\/lpfch.org\/vi\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Lucile Packard Foundation for Children's Health\" \/>\n<meta property=\"article:published_time\" content=\"2014-08-21T00:26:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-10-23T16:28:14+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1374\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#article\",\"isPartOf\":{\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/lpfch.org\/km\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c\"},\"headline\":\"Many Minds, One Goal: Toward a Cure for Childhood Cancer\",\"datePublished\":\"2014-08-21T00:26:35+00:00\",\"dateModified\":\"2024-10-23T16:28:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/\"},\"wordCount\":1723,\"commentCount\":0,\"image\":{\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg\",\"articleSection\":[\"In the News\"],\"inLanguage\":\"vi\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/\",\"url\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/\",\"name\":\"Many Minds, One Goal: Toward a Cure for Childhood Cancer - Lucile Packard Foundation for Children's Health\",\"isPartOf\":{\"@id\":\"https:\/\/lpfch.org\/km\/#website\"},\"primaryImageOfPage\":{\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#primaryimage\"},\"image\":{\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg\",\"datePublished\":\"2014-08-21T00:26:35+00:00\",\"dateModified\":\"2024-10-23T16:28:14+00:00\",\"author\":{\"@id\":\"https:\/\/lpfch.org\/km\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c\"},\"breadcrumb\":{\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#breadcrumb\"},\"inLanguage\":\"vi\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"vi\",\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#primaryimage\",\"url\":\"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg\",\"contentUrl\":\"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg\",\"width\":2560,\"height\":1374,\"caption\":\"Julien Sage, PhD works in his cancer lab.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/lpfch.org\/hy\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Many Minds, One Goal:…\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/lpfch.org\/km\/#website\",\"url\":\"https:\/\/lpfch.org\/km\/\",\"name\":\"Lucile Packard Foundation for Children's Health\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/lpfch.org\/km\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"vi\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/lpfch.org\/km\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"vi\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/lpfch.org\/wp\"],\"url\":\"https:\/\/lpfch.org\/vi\/impact-stories\/author\/admin\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Nhi\u1ec1u b\u1ed9 \u00f3c, m\u1ed9t m\u1ee5c ti\u00eau: H\u01b0\u1edbng t\u1edbi ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb ung th\u01b0 \u1edf tr\u1ebb em - Qu\u1ef9 Lucile Packard v\u00ec s\u1ee9c kh\u1ecfe tr\u1ebb em","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/lpfch.org\/vi\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/","og_locale":"vi_VN","og_type":"article","og_title":"Many Minds, One Goal: Toward a Cure for Childhood Cancer","og_description":"How does cancer start? Stanford cancer biologist Julien Sage, PhD, has spent much of his career tackling that fundamental question. Sage is not alone in...","og_url":"http:\/\/lpfch.org\/vi\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/","og_site_name":"Lucile Packard Foundation for Children's Health","article_published_time":"2014-08-21T00:26:35+00:00","article_modified_time":"2024-10-23T16:28:14+00:00","og_image":[{"width":2560,"height":1374,"url":"http:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#article","isPartOf":{"@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/"},"author":{"name":"admin","@id":"https:\/\/lpfch.org\/km\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c"},"headline":"Many Minds, One Goal: Toward a Cure for Childhood Cancer","datePublished":"2014-08-21T00:26:35+00:00","dateModified":"2024-10-23T16:28:14+00:00","mainEntityOfPage":{"@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/"},"wordCount":1723,"commentCount":0,"image":{"@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg","articleSection":["In the News"],"inLanguage":"vi","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#respond"]}]},{"@type":"WebPage","@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/","url":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/","name":"Nhi\u1ec1u b\u1ed9 \u00f3c, m\u1ed9t m\u1ee5c ti\u00eau: H\u01b0\u1edbng t\u1edbi ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb ung th\u01b0 \u1edf tr\u1ebb em - Qu\u1ef9 Lucile Packard v\u00ec s\u1ee9c kh\u1ecfe tr\u1ebb em","isPartOf":{"@id":"https:\/\/lpfch.org\/km\/#website"},"primaryImageOfPage":{"@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#primaryimage"},"image":{"@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg","datePublished":"2014-08-21T00:26:35+00:00","dateModified":"2024-10-23T16:28:14+00:00","author":{"@id":"https:\/\/lpfch.org\/km\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c"},"breadcrumb":{"@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#breadcrumb"},"inLanguage":"vi","potentialAction":[{"@type":"ReadAction","target":["http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/"]}]},{"@type":"ImageObject","inLanguage":"vi","@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#primaryimage","url":"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg","contentUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/manymindsonegoal-scaled.jpg","width":2560,"height":1374,"caption":"Julien Sage, PhD works in his cancer lab."},{"@type":"BreadcrumbList","@id":"http:\/\/lpfch.org\/impact-stories\/many-minds-one-goal-toward-a-cure-for-childhood-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lpfch.org\/hy\/"},{"@type":"ListItem","position":2,"name":"Many Minds, One Goal:…"}]},{"@type":"WebSite","@id":"https:\/\/lpfch.org\/km\/#website","url":"https:\/\/lpfch.org\/km\/","name":"Qu\u1ef9 Lucile Packard v\u00ec S\u1ee9c kh\u1ecfe Tr\u1ebb em","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lpfch.org\/km\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"vi"},{"@type":"Person","@id":"https:\/\/lpfch.org\/km\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c","name":"qu\u1ea3n tr\u1ecb vi\u00ean","image":{"@type":"ImageObject","inLanguage":"vi","@id":"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/lpfch.org\/wp"],"url":"https:\/\/lpfch.org\/vi\/impact-stories\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/posts\/3555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/comments?post=3555"}],"version-history":[{"count":2,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/posts\/3555\/revisions"}],"predecessor-version":[{"id":18838,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/posts\/3555\/revisions\/18838"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/media\/3556"}],"wp:attachment":[{"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/media?parent=3555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/categories?post=3555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}