{"id":3884,"date":"2017-05-03T21:28:03","date_gmt":"2017-05-03T21:28:03","guid":{"rendered":"https:\/\/lpfch.org\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/"},"modified":"2024-02-19T18:00:17","modified_gmt":"2024-02-19T18:00:17","slug":"unleashing-cancer-immunotherapy-against-a-diabolical-disease","status":"publish","type":"post","link":"https:\/\/lpfch.org\/vi\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/","title":{"rendered":"Gi\u1ea3i ph\u00f3ng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ung th\u01b0 ch\u1ed1ng l\u1ea1i c\u0103n b\u1ec7nh hi\u1ec3m ngh\u00e8o"},"content":{"rendered":"

Ch\u00ednh v\u00e0o n\u0103m l\u1edbp 6, Ti\u1ebfn s\u0129 Y khoa Crystal Mackall, ph\u00f3 gi\u00e1m \u0111\u1ed1c Vi\u1ec7n Ung th\u01b0 Stanford, gi\u00e1o s\u01b0 nhi khoa (huy\u1ebft h\u1ecdc\/ung th\u01b0 h\u1ecdc) v\u00e0 y khoa t\u1ea1i Tr\u01b0\u1eddng Y \u0110\u1ea1i h\u1ecdc Stanford, \u0111\u00e3 l\u1ea7n \u0111\u1ea7u ti\u00ean bi\u1ebft m\u00ecnh mu\u1ed1n tr\u1edf th\u00e0nh b\u00e1c s\u0129. "T\u00f4i c\u00f3 m\u1ed9t gi\u00e1o vi\u00ean khoa h\u1ecdc n\u1eef, ng\u01b0\u1eddi \u0111\u00e3 truy\u1ec1n c\u1ea3m h\u1ee9ng cho t\u00f4i r\u1ea5t nhi\u1ec1u", Mackall k\u1ec3 l\u1ea1i. "Ch\u00fang t\u00f4i \u0111\u00e3 h\u1ecdc r\u1ea5t nhi\u1ec1u v\u1ec1 gi\u1ea3i ph\u1eabu v\u00e0 sinh l\u00fd h\u1ecdc, v\u00e0 t\u00f4i ngh\u0129 \u0111\u00f3 l\u00e0 nh\u1eefng m\u00f4n h\u1ecdc tuy\u1ec7t v\u1eddi nh\u1ea5t tr\u00ean \u0111\u1eddi."<\/p>\n

Mackall, \u0111\u1ed3ng gi\u00e1m \u0111\u1ed1c y khoa c\u1ee7a Ph\u00f2ng th\u00ed nghi\u1ec7m Y h\u1ecdc T\u1ebf b\u00e0o v\u00e0 Gen Stanford, v\u1eabn ki\u00ean \u0111\u1ecbnh v\u1edbi \u01b0\u1edbc m\u01a1 c\u1ee7a m\u00ecnh, ngay c\u1ea3 khi c\u00f4 \u0111\u00e3 trau d\u1ed3i m\u1ee5c ti\u00eau trong qu\u00e1 tr\u00ecnh \u0111\u00e0o t\u1ea1o. "T\u00f4i t\u1eebng ngh\u0129 m\u00ecnh mu\u1ed1n tr\u1edf th\u00e0nh b\u00e1c s\u0129 ph\u1eabu thu\u1eadt tim", Mackall n\u00f3i, "nh\u01b0ng h\u00f3a ra t\u00f4i th\u1ef1c s\u1ef1 kh\u00f4ng gi\u1ecfi d\u00f9ng tay, v\u00e0 m\u0169i t\u00f4i lu\u00f4n ng\u1ee9a m\u1ed7i khi ph\u1ea3i v\u00e0o ph\u00f2ng ph\u1eabu thu\u1eadt".<\/p>\n

Ch\u1eb3ng bao l\u00e2u sau, c\u00f4 \u0111\u00e3 t\u00ecm th\u1ea5y s\u1ef1 ph\u00f9 h\u1ee3p ho\u00e0n h\u1ea3o: y h\u1ecdc ung th\u01b0 nhi khoa. "T\u00f4i ngh\u0129, \u0111\u00e2y ch\u00ednh l\u00e0 n\u01a1i m\u00ecnh mu\u1ed1n d\u1ed3n h\u1ebft t\u00e2m huy\u1ebft. Kh\u00f4ng c\u00f3 cu\u1ed9c chi\u1ebfn n\u00e0o tr\u00ean th\u1ebf gi\u1edbi n\u00e0y tuy\u1ec7t v\u1eddi h\u01a1n l\u00e0 chi\u1ebfn \u0111\u1ea5u v\u1edbi c\u0103n b\u1ec7nh ung th\u01b0 \u1edf tr\u1ebb em."<\/p>\n

K\u1ec3 t\u1eeb \u0111\u00f3, ch\u00ednh c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u c\u1ee7a Mackall \u0111\u00e3 g\u00f3p ph\u1ea7n \u0111\u1ecbnh h\u00ecnh chi\u1ebfn tuy\u1ebfn. N\u0103m 1984, b\u00e0 \u0111\u1ecdc \u0111\u01b0\u1ee3c m\u1ed9t b\u00e0i b\u00e1o \u0111\u1ea7u ti\u00ean v\u1ec1 li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ung th\u01b0 - m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p s\u1eed d\u1ee5ng h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a ch\u00ednh c\u01a1 th\u1ec3 \u0111\u1ec3 ch\u1ed1ng l\u1ea1i t\u1ebf b\u00e0o ung th\u01b0. "Ch\u01b0a ai t\u1eebng ngh\u0129 r\u1eb1ng n\u00f3 th\u1ef1c s\u1ef1 hi\u1ec7u qu\u1ea3", Mackall, ng\u01b0\u1eddi v\u1eabn c\u00f2n nh\u1edb nh\u01b0 in nh\u1eefng ng\u00e0y \u0111\u1ea7u khi "ch\u00fang t\u00f4i c\u00f2n l\u00e0 m\u1ed9t th\u00e0nh ph\u1ea7n ngo\u00e0i l\u1ec1 trong ng\u00e0nh ung th\u01b0 h\u1ecdc. M\u1ecdi ng\u01b0\u1eddi c\u1ee9 ngh\u0129 ch\u00fang t\u00f4i h\u01a1i 'l\u1ea1c lo\u00e0i'".<\/p>\n

H\u01b0\u1edbng d\u1eabn t\u00e1o b\u1ea1o<\/h3>\n

\u0110\u1ebfn n\u0103m 1989, b\u00e0 \u0111\u00e3 nghi\u00ean c\u1ee9u h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch trong b\u1ec7nh ung th\u01b0 t\u1ea1i Vi\u1ec7n Y t\u1ebf Qu\u1ed1c gia d\u01b0\u1edbi s\u1ef1 h\u01b0\u1edbng d\u1eabn c\u1ee7a Ti\u1ebfn s\u0129 Philip Pizzo, tr\u01b0\u1edfng khoa Nhi c\u1ee7a Vi\u1ec7n Ung th\u01b0 Qu\u1ed1c gia v\u00e0 sau n\u00e0y tr\u1edf th\u00e0nh hi\u1ec7u tr\u01b0\u1edfng Tr\u01b0\u1eddng Y khoa \u0110\u1ea1i h\u1ecdc Stanford t\u1eeb n\u0103m 2001 \u0111\u1ebfn n\u0103m 2012.<\/p>\n

\u201cNgay t\u1eeb \u0111\u1ea7u, Crystal \u0111\u00e3 t\u00e2m huy\u1ebft v\u1edbi mi\u1ec5n d\u1ecbch h\u1ecdc v\u00e0 ti\u1ec1m n\u0103ng c\u1ee7a li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch,\u201d Pizzo nh\u1edb l\u1ea1i. \u201cT\u00f4i th\u1ef1c s\u1ef1 \u1ea5n t\u01b0\u1ee3ng b\u1edfi \u0111i\u1ec1u \u0111\u00f3, v\u00e0 r\u1ea5t vui m\u1eebng khi ch\u1ee9ng ki\u1ebfn c\u00f4 \u1ea5y ph\u00e1t tri\u1ec3n t\u1ea1i Vi\u1ec7n Ung th\u01b0 Qu\u1ed1c gia \u0111\u1ec3 theo \u0111u\u1ed5i t\u1ea7m nh\u00ecn c\u1ee7a m\u00ecnh v\u00e0 cu\u1ed1i c\u00f9ng \u0111\u1ea1t \u0111\u01b0\u1ee3c v\u1ecb tr\u00ed l\u00e3nh \u0111\u1ea1o m\u00e0 t\u00f4i \u0111\u00e3 t\u1eebng n\u1eafm gi\u1eef.\u201d<\/p>\n

Mackall cho bi\u1ebft: \u201cPhil Pizzo \u0111\u00e3 d\u1ea1y t\u00f4i ph\u1ea3i m\u1ea1nh d\u1ea1n trong vi\u1ec7c nghi\u00ean c\u1ee9u l\u00e2m s\u00e0ng \u1edf tr\u1ebb em m\u1eafc b\u1ec7nh hi\u1ec3m ngh\u00e8o v\u00e0 trong vi\u1ec7c t\u1ea1o ra ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi cho tr\u1ebb em\u201d.<\/p>\n

S\u1ef1 t\u00e1o b\u1ea1o \u0111\u00f3 \u0111\u00e3 ti\u1ebfp th\u00eam s\u1ee9c m\u1ea1nh cho Mackall ki\u00ean tr\u00ec h\u01a1n hai th\u1eadp k\u1ef7, khi b\u00e0 v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p d\u1ea7n kh\u00e1m ph\u00e1 ra nh\u1eefng b\u00ed m\u1eadt c\u1ee7a li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch. Nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn ban \u0111\u1ea7u b\u1eaft \u0111\u1ea7u cho th\u1ea5y nhi\u1ec1u h\u1ee9a h\u1eb9n. "Nh\u1eefng c\u0103n b\u1ec7nh ung th\u01b0 kh\u00e1ng m\u1ecdi lo\u1ea1i li\u1ec7u ph\u00e1p kh\u00e1c \u0111\u00e3 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ki\u1ec3m so\u00e1t v\u00e0 thuy\u00ean gi\u1ea3m nh\u1edd li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch", Mackall n\u00f3i.<\/p>\n

R\u1ed3i \u201cm\u1ecdi th\u1ee9 \u0111\u00e3 thay \u0111\u1ed5i v\u00e0o n\u0103m 2010\u201d, khi Vi\u1ec7n Ung th\u01b0 Qu\u1ed1c gia, d\u01b0\u1edbi s\u1ef1 l\u00e3nh \u0111\u1ea1o c\u1ee7a Mackall, b\u00e1o c\u00e1o m\u1ed9t trong nh\u1eefng th\u00e0nh c\u00f4ng l\u00e2m s\u00e0ng \u0111\u1ea7u ti\u00ean v\u1edbi ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn m\u1ee5c ti\u00eau nh\u1eb1m k\u00edch ho\u1ea1t ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch c\u1ee7a c\u01a1 th\u1ec3. \u201cM\u1ecdi th\u1ee9 nh\u01b0 b\u00f9ng n\u1ed5\u201d, Mackall n\u00f3i th\u00eam. \u201cGi\u1edd \u0111\u00e2y, n\u00f3 \u0111\u00e3 tr\u1edf th\u00e0nh b\u01b0\u1edbc ngo\u1eb7t l\u1edbn nh\u1ea5t trong y h\u1ecdc ung th\u01b0.\u201d<\/p>\n

M\u1eb7c d\u00f9 \u0111\u00e3 c\u00f3 nhi\u1ec1u ti\u1ebfn b\u1ed9 trong \u0111i\u1ec1u tr\u1ecb v\u00e0 kh\u1ea3 n\u0103ng s\u1ed1ng s\u00f3t c\u1ee7a b\u1ec7nh ung th\u01b0 \u1edf tr\u1ebb em trong b\u1ed1n th\u1eadp k\u1ef7 qua, li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ung th\u01b0 v\u1eabn r\u1ea5t c\u1ea7n \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u th\u00eam. V\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb nh\u01b0 h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb v\u00e0 gh\u00e9p t\u1ebf b\u00e0o g\u1ed1c, t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t sau 5 n\u0103m c\u1ee7a tr\u1ebb em m\u1eafc ung th\u01b0 hi\u1ec7n \u0111\u1ea1t tr\u00ean 85%, so v\u1edbi m\u1ee9c 10% tr\u01b0\u1edbc \u0111\u00e2y. Tuy nhi\u00ean, t\u1ef7 l\u1ec7 s\u1ed1ng s\u00f3t th\u1ea5p h\u01a1n nhi\u1ec1u \u0111\u1ed1i v\u1edbi c\u00e1c lo\u1ea1i ung th\u01b0 hi\u1ebfm g\u1eb7p, v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ti\u00eau chu\u1ea9n c\u00f3 th\u1ec3 k\u00e9o d\u00e0i, \u0111\u00f4i khi m\u1ea5t nhi\u1ec1u n\u0103m, v\u00e0 c\u00f3 nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng. (Xem \u201cNgay c\u1ea3 Wondergirl c\u0169ng c\u1ea7n nh\u1eefng anh h\u00f9ng<\/a>.\u201d) V\u00e0 c\u00f3 nh\u1eefng tr\u1ebb em m\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7n t\u1ea1i kh\u00f4ng hi\u1ec7u qu\u1ea3 ho\u1eb7c b\u1ecb t\u00e1i ph\u00e1t nhi\u1ec1u l\u1ea7n, khi\u1ebfn b\u1ec7nh kh\u00f4ng c\u00f2n \u0111\u00e1p \u1ee9ng t\u1ed1t v\u1edbi ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb.<\/p>\n

\u201cUng th\u01b0 th\u1eadt t\u00e0n kh\u1ed1c,\u201d Mackall n\u00f3i. \u201cN\u00f3 th\u00edch nghi v\u00e0 li\u00ean t\u1ee5c t\u00ecm c\u00e1ch quay tr\u1edf l\u1ea1i. Ch\u00fang ta ph\u1ea3i \u0111\u00e1nh b\u1ea1i n\u00f3.\u201d<\/p>\n

M\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn c\u00f3 m\u1ee5c ti\u00eau<\/h3>\n

M\u1ed9t ch\u00eca kh\u00f3a cho s\u1ef1 ti\u1ebfn b\u1ed9 c\u1ee7a c\u00f4 trong vi\u1ec7c chi\u1ebfn th\u1eafng ung th\u01b0 n\u1eb1m \u1edf s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa kh\u1ed1i u \u1edf tr\u1ebb em v\u00e0 kh\u1ed1i u \u1edf ng\u01b0\u1eddi l\u1edbn. C\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch t\u00ecm ki\u1ebfm nh\u1eefng b\u1ea5t th\u01b0\u1eddng, v\u1ed1n r\u1ea5t d\u1ec5 ph\u00e1t hi\u1ec7n \u1edf ung th\u01b0 ng\u01b0\u1eddi l\u1edbn v\u00ec ch\u00fang c\u00f3 r\u1ea5t nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn. V\u00ec kh\u1ed1i u \u1edf tr\u1ebb em c\u00f3 \u00edt b\u1ea5t th\u01b0\u1eddng h\u01a1n, n\u00ean "ch\u00fang tr\u00f4ng gi\u1ed1ng m\u1ed9t t\u1ebf b\u00e0o ch\u01b0a tr\u01b0\u1edfng th\u00e0nh h\u01a1n, n\u00ean h\u1ec7 mi\u1ec5n d\u1ecbch kh\u00f4ng th\u1ec3 ph\u00e1t hi\u1ec7n ra", Mackall n\u00f3i. \u0110i\u1ec1u n\u00e0y nghe c\u00f3 v\u1ebb tr\u00e1i ng\u01b0\u1ee3c, nh\u01b0ng ch\u00ednh s\u1ef1 ho\u00e0n h\u1ea3o t\u01b0\u01a1ng \u0111\u1ed1i c\u1ee7a kh\u1ed1i u \u1edf tr\u1ebb em c\u0169ng khi\u1ebfn vi\u1ec7c ch\u1ed1ng l\u1ea1i ch\u00fang tr\u1edf n\u00ean kh\u00f3 kh\u0103n h\u01a1n.<\/p>\n

\u0110\u00f3 l\u00e0 l\u00fd do t\u1ea1i sao Mackall t\u1eadp trung n\u1ed7 l\u1ef1c v\u00e0o l\u1eddi h\u1ee9a v\u1ec1 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p nh\u1eafm v\u00e0o c\u00e1c t\u1ebf b\u00e0o \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh trong m\u1ed9t lo\u1ea1i kh\u1ed1i u c\u1ee5 th\u1ec3, ch\u1eb3ng h\u1ea1n nh\u01b0 b\u1ec7nh b\u1ea1ch c\u1ea7u. S\u1eed d\u1ee5ng c\u00e1i m\u00e0 b\u00e0 g\u1ecdi l\u00e0 sinh h\u1ecdc t\u1ed5ng h\u1ee3p, "ch\u00fang t\u00f4i t\u1ea1o ra m\u1ed9t th\u1ee9 g\u00ec \u0111\u00f3 m\u1edbi m\u1ebb. Ch\u00fang t\u00f4i chi\u1ebfm quy\u1ec1n \u0111i\u1ec1u khi\u1ec3n h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch", b\u00e0 n\u00f3i. "N\u00f3 gi\u1ed1ng nh\u01b0 m\u1ed9t con ch\u00f3 s\u0103n v\u1eady. B\u1ea1n \u0111\u00e1nh h\u01a1i th\u1ea5y m\u00f9i v\u00e0 ra l\u1ec7nh, '\u0110i b\u1eaft n\u00f3 \u0111i.'" Trong ung th\u01b0 nhi khoa, vi\u1ec7c ch\u1ec9 d\u1eabn h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch \u0111\u1ebfn m\u1ed9t b\u1ea5t th\u01b0\u1eddng ho\u1eb7c \u0111\u1ed9t bi\u1ebfn l\u00e0 ch\u01b0a \u0111\u1ee7, v\u00ec s\u1ed1 l\u01b0\u1ee3ng b\u1ea5t th\u01b0\u1eddng ho\u1eb7c \u0111\u1ed9t bi\u1ebfn kh\u00f4ng \u0111\u1ee7. "Ch\u00fang t\u00f4i ph\u1ea3i th\u1ef1c s\u1ef1 d\u1eabn d\u1eaft c\u00e1c t\u1ebf b\u00e0o \u0111\u1ebfn kh\u1ed1i u."<\/p>\n

T\u1ebf b\u00e0o T - "nh\u1eefng con ch\u00f3 s\u0103n" - \u0111\u01b0\u1ee3c l\u1ea5y ra kh\u1ecfi b\u1ec7nh nh\u00e2n, \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u1edbi "m\u00f9i" trong ph\u00e9p lo\u1ea1i suy c\u1ee7a Mackall, \u0111\u00f3 l\u00e0 th\u1ee5 th\u1ec3 kh\u00e1ng nguy\u00ean kh\u1ea3m (CAR), v\u00e0 sau \u0111\u00f3 \u0111\u01b0\u1ee3c \u0111\u01b0a tr\u1edf l\u1ea1i m\u00e1u c\u1ee7a b\u1ec7nh nh\u00e2n \u0111\u1ec3 b\u1eaft \u0111\u1ea7u ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch tr\u1ecb li\u1ec7u m\u1ee5c ti\u00eau c\u1ee7a ch\u00fang. CAR h\u01b0\u1edbng t\u1ebf b\u00e0o T \u0111\u1ebfn m\u1ed9t t\u1ebf b\u00e0o kh\u1ed1i u c\u1ee5 th\u1ec3, ch\u1eb3ng h\u1ea1n nh\u01b0 CD19 trong b\u1ec7nh b\u1ea1ch c\u1ea7u lymphoblastic c\u1ea5p t\u00ednh (ALL). Khi \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch CD19-CAR \u1edf ph\u1ea1m vi li\u1ec1u ho\u1ea1t \u0111\u1ed9ng, tr\u1ebb em trong c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng m\u1eafc ALL - t\u1ea5t c\u1ea3 \u0111\u1ec1u \u0111\u00e3 t\u00e1i ph\u00e1t tr\u01b0\u1edbc \u0111\u00f3 ho\u1eb7c kh\u00f4ng c\u00f2n l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb n\u00e0o kh\u00e1c - \u0111\u00e3 th\u1ea5y t\u1ef7 l\u1ec7 \u0111\u00e1p \u1ee9ng l\u00e0 80 ph\u1ea7n tr\u0103m. \u0110\u00e2y c\u0169ng l\u00e0 m\u1ed9t li\u1ec7u tr\u00ecnh \u0111i\u1ec1u tr\u1ecb ng\u1eafn h\u01a1n so v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn ti\u00eau chu\u1ea9n v\u00e0 b\u00e0 d\u1ef1 \u0111o\u00e1n s\u1ebd c\u00f3 \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 l\u00e2u d\u00e0i h\u01a1n. Mackall hy v\u1ecdng FDA s\u1ebd ph\u00ea duy\u1ec7t CD19-CAR trong t\u01b0\u01a1ng lai g\u1ea7n.<\/p>\n

D\u1ef1a tr\u00ean nh\u1eefng k\u1ebft qu\u1ea3 kh\u1ea3 quan v\u1edbi CD19-CAR, Mackall v\u00e0 nh\u00f3m c\u1ee7a b\u00e0 \u0111\u00e3 nghi\u00ean c\u1ee9u m\u1ee5c ti\u00eau th\u1ee9 hai: CD22. C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng cho CD22 \u0111\u00e3 b\u1eaft \u0111\u1ea7u v\u00e0o n\u0103m 2015, v\u00e0 Mackall s\u1ebd s\u1edbm c\u00f4ng b\u1ed1 k\u1ebft qu\u1ea3. Vi\u1ec7c c\u00f3 m\u1ee5c ti\u00eau th\u1ee9 hai trong tay gi\u1edd \u0111\u00e2y mang \u0111\u1ebfn cho c\u00e1c b\u00e1c s\u0129 c\u01a1 h\u1ed9i l\u00e0m nhi\u1ec1u h\u01a1n l\u00e0 th\u1eed t\u1eebng m\u1ee5c ti\u00eau li\u00ean ti\u1ebfp, m\u00e0 l\u00e0 \u0111\u1ea1t \u0111\u01b0\u1ee3c c\u1ea3 hai m\u1ee5c ti\u00eau c\u00f9ng m\u1ed9t l\u00fac. "Th\u1ef1c hi\u1ec7n t\u1eebng b\u01b0\u1edbc m\u1ed9t d\u01b0\u1eddng nh\u01b0 khi\u1ebfn kh\u1ed1i u c\u00f3 qu\u00e1 nhi\u1ec1u th\u1eddi gian \u0111\u1ec3 th\u00edch nghi", Mackall n\u00f3i. "V\u00ec v\u1eady, ch\u00fang t\u00f4i hi\u1ec7n \u0111ang ti\u1ebfn h\u00e0nh th\u1eed nghi\u1ec7m CAR k\u00e9p \u0111\u1ea7u ti\u00ean." Th\u1eed nghi\u1ec7m CAR k\u00e9p \u0111\u1ea7u ti\u00ean tr\u00ean ng\u01b0\u1eddi, nh\u1eafm v\u00e0o CD19 v\u00e0 CD22, s\u1ebd b\u1eaft \u0111\u1ea7u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng t\u1ea1i Stanford v\u00e0 Vi\u1ec7n Ung th\u01b0 Qu\u1ed1c gia trong v\u00e0i th\u00e1ng t\u1edbi.<\/p>\n

B\u00ean c\u1ea1nh vi\u1ec7c ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch, Mackall c\u0169ng quy\u1ebft t\u00e2m ti\u1ebfp t\u1ee5c nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a n\u00f3, bao g\u1ed3m, trong nh\u1eefng tr\u01b0\u1eddng h\u1ee3p r\u1ea5t hi\u1ebfm, \u0111\u1ed9c t\u00ednh th\u1ea7n kinh. "Khi b\u1ea1n k\u00edch ho\u1ea1t h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch, b\u1ea1n ph\u1ea3i k\u00edch ho\u1ea1t n\u00f3 th\u1eadt m\u1ea1nh \u0111\u1ec3 ch\u1ed1ng l\u1ea1i ung th\u01b0, v\u00e0 \u0111i\u1ec1u \u0111\u00f3 \u0111\u00f4i khi c\u00f3 th\u1ec3 g\u00e2y ra c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng, \u0111\u00f4i khi c\u00f3 th\u1ec3 \u0111e d\u1ecda t\u00ednh m\u1ea1ng", Mackall n\u00f3i. "Ch\u00fang t\u00f4i \u0111ang n\u1ed7 l\u1ef1c kh\u00f4ng ch\u1ec9 \u0111\u1ec3 kh\u00e1m ph\u00e1 ra nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ung th\u01b0 t\u1ed1t h\u01a1n, t\u1ea1o ra c\u00e1c li\u1ec7u ph\u00e1p m\u1edbi v\u00e0 \u0111\u01b0a ch\u00fang v\u00e0o th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng, m\u00e0 c\u00f2n \u0111\u1ec3 t\u00ecm hi\u1ec3u v\u1ec1 \u0111\u1ed9c t\u00ednh v\u00e0 l\u00e0m cho vi\u1ec7c \u0111i\u1ec1u tr\u1ecb an to\u00e0n h\u01a1n."<\/p>\n

\u0110\u1ea9y nhanh nghi\u00ean c\u1ee9u<\/h3>\n

Hai t\u1ed5 ch\u1ee9c \u0111\u00e3 b\u1eaft \u0111\u1ea7u h\u1ed7 tr\u1ee3 nghi\u00ean c\u1ee9u li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ung th\u01b0 \u1edf tr\u1ebb em t\u1eeb r\u1ea5t s\u1edbm v\u00e0 v\u1edbi kho\u1ea3n \u0111\u1ea7u t\u01b0 \u0111\u00e1ng k\u1ec3 l\u00e0 Stand Up 2 Cancer v\u00e0 St. Baldrick's Foundation, v\u00e0 t\u1eeb n\u0103m 2013, h\u1ecd \u0111\u00e3 b\u1eaft \u0111\u1ea7u t\u00e0i tr\u1ee3 cho Pediatric Cancer Dream Team, m\u1ed9t nh\u00f3m g\u1ed3m t\u00e1m t\u1ed5 ch\u1ee9c do Mackall \u0111\u1ed3ng l\u00e3nh \u0111\u1ea1o. B\u1ec7nh vi\u1ec7n Nhi \u0111\u1ed3ng Lucile Packard Stanford \u0111\u00e3 tr\u1edf th\u00e0nh m\u1ed9t ph\u1ea7n c\u1ee7a Pediatric Cancer Dream Team v\u00e0o th\u00e1ng 1 n\u0103m 2016, khi Mackall gia nh\u1eadp khoa Y c\u1ee7a \u0110\u1ea1i h\u1ecdc Stanford. Vi\u1ec7n Mi\u1ec5n d\u1ecbch Ung th\u01b0 Parker m\u1edbi, do nh\u00e0 t\u1eeb thi\u1ec7n v\u00e0 doanh nh\u00e2n Sean Parker l\u00e3nh \u0111\u1ea1o, c\u0169ng h\u1ed7 tr\u1ee3 c\u01a1 s\u1edf h\u1ea1 t\u1ea7ng v\u00e0 nghi\u00ean c\u1ee9u.<\/p>\n

Ngay c\u1ea3 v\u1edbi ngu\u1ed3n t\u00e0i tr\u1ee3 n\u00e0y, ung th\u01b0 tr\u1ebb em v\u1eabn mang \u0111\u1ebfn nhi\u1ec1u c\u01a1 h\u1ed9i h\u1ed7 tr\u1ee3 to l\u1edbn. "Ung th\u01b0 kh\u00f4ng ph\u1ea3i l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh", Mackall n\u00f3i. "\u0110\u00f3 l\u00e0 m\u1ed9t t\u1eadp h\u1ee3p c\u00e1c b\u1ec7nh kh\u00e1c nhau. M\u1ed7i b\u1ec7nh c\u00f3 m\u1ed9t b\u1ed9 m\u1ee5c ti\u00eau kh\u00e1c nhau, \u0111\u00f2i h\u1ecfi m\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u kh\u00e1c nhau ph\u1ea3i ph\u00e1t tri\u1ec3n, b\u1edfi v\u00ec b\u1ea1n kh\u00f4ng th\u1ec3 nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o m\u1ed9t c\u0103n b\u1ec7nh n\u1ebfu kh\u00f4ng hi\u1ec3u r\u00f5 v\u1ec1 n\u00f3. \u0110\u00f3 ch\u00ednh l\u00e0 \u0111i\u1ec3m h\u1ea5p d\u1eabn c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn CAR m\u1edbi n\u00e0y: C\u00f3 v\u1ebb nh\u01b0 n\u00f3 c\u00f3 th\u1ec3 \u0111i\u1ec1u tr\u1ecb \u0111\u01b0\u1ee3c ung th\u01b0 r\u1eafn ho\u1eb7c ung th\u01b0 m\u00e1u, v\u00e0 ch\u00fang t\u00f4i c\u00f3 th\u1ec3 k\u1ebft h\u1ee3p n\u00f3 v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb kh\u00e1c."<\/p>\n

Mackall n\u00f3i th\u00eam: "C\u00f3 r\u1ea5t nhi\u1ec1u c\u01a1 h\u1ed9i \u0111\u1ec3 ch\u00fang ta c\u00f3 th\u1ec3 gi\u1ea3i quy\u1ebft ti\u1ebfp theo".<\/p>\n

\u201cNh\u01b0ng hi\u1ec7n t\u1ea1i, ch\u00fang ta ph\u1ea3i l\u1ef1a ch\u1ecdn d\u1ef1a tr\u00ean ngu\u1ed3n l\u1ef1c. Nhi\u1ec1u ti\u1ec1n h\u01a1n s\u1ebd cho ph\u00e9p ch\u00fang ta gi\u1ea3i quy\u1ebft nhi\u1ec1u lo\u1ea1i ung th\u01b0 c\u00f9ng l\u00fac.\u201d<\/p>\n

V\u1edbi Mackall d\u1eabn d\u1eaft nghi\u00ean c\u1ee9u n\u00e0y, Stanford s\u1ebd g\u00f3p ph\u1ea7n \u0111\u01b0a l\u0129nh v\u1ef1c ung th\u01b0 nhi khoa b\u01b0\u1edbc v\u00e0o m\u1ed9t l\u0129nh v\u1ef1c kh\u00e1m ph\u00e1 v\u00e0 \u0111i\u1ec1u tr\u1ecb m\u1edbi, kh\u00f4ng ch\u1ec9 \u0111\u1ecbnh ngh\u0129a l\u1ea1i c\u00e1ch ch\u00fang ta hi\u1ec3u v\u1ec1 ung th\u01b0 nhi khoa, m\u00e0 c\u00f2n \u0111\u1ecbnh ngh\u0129a l\u1ea1i c\u00e1ch ch\u00fang ta n\u1ed7 l\u1ef1c x\u00f3a b\u1ecf n\u00f3. \u0110\u00e2y l\u00e0 m\u1ed9t c\u00f4ng tr\u00ecnh \u0111\u1ea7y c\u1ea3m h\u1ee9ng t\u1eeb m\u1ed9t c\u1ef1u h\u1ecdc sinh l\u1edbp 6, ng\u01b0\u1eddi v\u1eeba m\u1edbi t\u1eadn h\u01b0\u1edfng gi\u1edd khoa h\u1ecdc.<\/p>\n

B\u00e0i vi\u1ebft n\u00e0y l\u1ea7n \u0111\u1ea7u ti\u00ean xu\u1ea5t hi\u1ec7n tr\u00ean \u1ea5n b\u1ea3n M\u00f9a xu\u00e2n n\u0103m 2017 c\u1ee7a Tin t\u1ee9c tr\u1ebb em Lucile Packard<\/a>.<\/em><\/p>\n

NGHE: Crystal Mackall th\u1ea3o lu\u1eadn v\u1ec1 v\u1ea5n \u0111\u1ec1 l\u1edbn nh\u1ea5t li\u00ean quan \u0111\u1ebfn ung th\u01b0 trong nhi\u1ec1u th\u1eadp k\u1ef7 t\u1ea1i supportLPCH.org\/fight<\/a>.<\/strong><\/p>","protected":false},"excerpt":{"rendered":"

V\u00e0o l\u1edbp 6, Ti\u1ebfn s\u0129 Crystal Mackall, ph\u00f3 gi\u00e1m \u0111\u1ed1c Vi\u1ec7n Ung th\u01b0 Stanford v\u00e0 gi\u00e1o s\u01b0 nhi khoa (huy\u1ebft h\u1ecdc\/ung th\u01b0) v\u00e0 y khoa t\u1ea1i\u2026<\/p>","protected":false},"author":17,"featured_media":3885,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[148],"class_list":["post-3884","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-the-news"],"acf":[],"yoast_head":"\nUnleashing Cancer Immunotherapy Against a Diabolical Disease - Lucile Packard Foundation for Children's Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/lpfch.org\/vi\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Unleashing Cancer Immunotherapy Against a Diabolical Disease\" \/>\n<meta property=\"og:description\" content=\"It was in 6th grade that Crystal Mackall, MD, associate director of the Stanford Cancer Institute and professor of pediatrics (hematology\/oncology) and of medicine at...\" \/>\n<meta property=\"og:url\" content=\"http:\/\/lpfch.org\/vi\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Lucile Packard Foundation for Children's Health\" \/>\n<meta property=\"article:published_time\" content=\"2017-05-03T21:28:03+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-19T18:00:17+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/mackall.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"308\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/#article\",\"isPartOf\":{\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/vi\\\/#\\\/schema\\\/person\\\/0c27ee3a03f60d4845413e6163db996c\"},\"headline\":\"Unleashing Cancer Immunotherapy Against a Diabolical Disease\",\"datePublished\":\"2017-05-03T21:28:03+00:00\",\"dateModified\":\"2024-02-19T18:00:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/\"},\"wordCount\":1428,\"commentCount\":0,\"image\":{\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/lpfch.org\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/mackall.jpg\",\"articleSection\":[\"In the News\"],\"inLanguage\":\"vi\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/\",\"url\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/\",\"name\":\"Unleashing Cancer Immunotherapy Against a Diabolical Disease - Lucile Packard Foundation for Children's Health\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/vi\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/#primaryimage\"},\"image\":{\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/lpfch.org\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/mackall.jpg\",\"datePublished\":\"2017-05-03T21:28:03+00:00\",\"dateModified\":\"2024-02-19T18:00:17+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/lpfch.org\\\/vi\\\/#\\\/schema\\\/person\\\/0c27ee3a03f60d4845413e6163db996c\"},\"breadcrumb\":{\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/#breadcrumb\"},\"inLanguage\":\"vi\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"vi\",\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/#primaryimage\",\"url\":\"https:\\\/\\\/lpfch.org\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/mackall.jpg\",\"contentUrl\":\"https:\\\/\\\/lpfch.org\\\/wp-content\\\/uploads\\\/2024\\\/01\\\/mackall.jpg\",\"width\":400,\"height\":308},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\\\/\\\/lpfch.org\\\/ja\\\/impact-stories\\\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/lpfch.org\\\/hy\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Unleashing Cancer…\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/vi\\\/#website\",\"url\":\"https:\\\/\\\/lpfch.org\\\/vi\\\/\",\"name\":\"Lucile Packard Foundation for Children's Health\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/lpfch.org\\\/vi\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"vi\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/lpfch.org\\\/vi\\\/#\\\/schema\\\/person\\\/0c27ee3a03f60d4845413e6163db996c\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"vi\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\\\/\\\/lpfch.org\\\/wp\"],\"url\":\"https:\\\/\\\/lpfch.org\\\/vi\\\/impact-stories\\\/author\\\/admin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Gi\u1ea3i ph\u00f3ng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ch\u1ed1ng l\u1ea1i c\u0103n b\u1ec7nh hi\u1ec3m ngh\u00e8o - Qu\u1ef9 Lucile Packard v\u00ec s\u1ee9c kh\u1ecfe tr\u1ebb em","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/lpfch.org\/vi\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/","og_locale":"vi_VN","og_type":"article","og_title":"Unleashing Cancer Immunotherapy Against a Diabolical Disease","og_description":"It was in 6th grade that Crystal Mackall, MD, associate director of the Stanford Cancer Institute and professor of pediatrics (hematology\/oncology) and of medicine at...","og_url":"http:\/\/lpfch.org\/vi\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/","og_site_name":"Lucile Packard Foundation for Children's Health","article_published_time":"2017-05-03T21:28:03+00:00","article_modified_time":"2024-02-19T18:00:17+00:00","og_image":[{"width":400,"height":308,"url":"http:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/mackall.jpg","type":"image\/jpeg"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/#article","isPartOf":{"@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/"},"author":{"name":"admin","@id":"https:\/\/lpfch.org\/vi\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c"},"headline":"Unleashing Cancer Immunotherapy Against a Diabolical Disease","datePublished":"2017-05-03T21:28:03+00:00","dateModified":"2024-02-19T18:00:17+00:00","mainEntityOfPage":{"@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/"},"wordCount":1428,"commentCount":0,"image":{"@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/mackall.jpg","articleSection":["In the News"],"inLanguage":"vi","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/#respond"]}]},{"@type":"WebPage","@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/","url":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/","name":"Gi\u1ea3i ph\u00f3ng li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ch\u1ed1ng l\u1ea1i c\u0103n b\u1ec7nh hi\u1ec3m ngh\u00e8o - Qu\u1ef9 Lucile Packard v\u00ec s\u1ee9c kh\u1ecfe tr\u1ebb em","isPartOf":{"@id":"https:\/\/lpfch.org\/vi\/#website"},"primaryImageOfPage":{"@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/#primaryimage"},"image":{"@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/#primaryimage"},"thumbnailUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/mackall.jpg","datePublished":"2017-05-03T21:28:03+00:00","dateModified":"2024-02-19T18:00:17+00:00","author":{"@id":"https:\/\/lpfch.org\/vi\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c"},"breadcrumb":{"@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/#breadcrumb"},"inLanguage":"vi","potentialAction":[{"@type":"ReadAction","target":["http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/"]}]},{"@type":"ImageObject","inLanguage":"vi","@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/#primaryimage","url":"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/mackall.jpg","contentUrl":"https:\/\/lpfch.org\/wp-content\/uploads\/2024\/01\/mackall.jpg","width":400,"height":308},{"@type":"BreadcrumbList","@id":"http:\/\/lpfch.org\/ja\/impact-stories\/unleashing-cancer-immunotherapy-against-a-diabolical-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/lpfch.org\/hy\/"},{"@type":"ListItem","position":2,"name":"Unleashing Cancer…"}]},{"@type":"WebSite","@id":"https:\/\/lpfch.org\/vi\/#website","url":"https:\/\/lpfch.org\/vi\/","name":"Qu\u1ef9 Lucile Packard v\u00ec S\u1ee9c kh\u1ecfe Tr\u1ebb em","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/lpfch.org\/vi\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"vi"},{"@type":"Person","@id":"https:\/\/lpfch.org\/vi\/#\/schema\/person\/0c27ee3a03f60d4845413e6163db996c","name":"qu\u1ea3n tr\u1ecb vi\u00ean","image":{"@type":"ImageObject","inLanguage":"vi","@id":"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/01a869e9508babcb1c66b6b41356b4ef63d5326e5b27c38b27ed4a46b8e36b9f?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/lpfch.org\/wp"],"url":"https:\/\/lpfch.org\/vi\/impact-stories\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/posts\/3884","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/comments?post=3884"}],"version-history":[{"count":2,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/posts\/3884\/revisions"}],"predecessor-version":[{"id":16146,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/posts\/3884\/revisions\/16146"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/media\/3885"}],"wp:attachment":[{"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/media?parent=3884"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lpfch.org\/vi\/wp-json\/wp\/v2\/categories?post=3884"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}