{"id":3888,"date":"2017-05-04T20:18:29","date_gmt":"2017-05-04T20:18:29","guid":{"rendered":"https:\/\/lpfch.org\/stanford-scientists-describe-stem-cell-and-gene-therapy-advances-in-scientific-symposium\/"},"modified":"2024-02-14T14:07:37","modified_gmt":"2024-02-14T14:07:37","slug":"stanford-scientists-describe-stem-cell-and-gene-therapy-advances-in-scientific-symposium","status":"publish","type":"post","link":"https:\/\/lpfch.org\/vi\/impact-stories\/stanford-scientists-describe-stem-cell-and-gene-therapy-advances-in-scientific-symposium\/","title":{"rendered":"C\u00e1c nh\u00e0 khoa h\u1ecdc Stanford m\u00f4 t\u1ea3 nh\u1eefng ti\u1ebfn b\u1ed9 c\u1ee7a li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o g\u1ed1c v\u00e0 gen trong h\u1ed9i th\u1ea3o khoa h\u1ecdc"},"content":{"rendered":"<p>Vi\u1ec7c s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c v\u00e0 li\u1ec7u ph\u00e1p gen \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c ch\u1eefa kh\u1ecfi b\u1ec7nh c\u00f3 v\u1ebb v\u1eabn gi\u1ed1ng nh\u01b0 khoa h\u1ecdc vi\u1ec5n t\u01b0\u1edfng, nh\u01b0ng m\u1ed9t cu\u1ed9c h\u1ecdp khoa h\u1ecdc g\u1ea7n \u0111\u00e2y \u0111\u00e3 nh\u1ea5n m\u1ea1nh t\u1ea5t c\u1ea3 c\u00e1c kh\u00eda c\u1ea1nh m\u00e0 li\u1ec7u ph\u00e1p n\u00e0y \u0111ang ng\u00e0y c\u00e0ng ti\u1ebfn g\u1ea7n h\u01a1n \u0111\u1ebfn s\u1ef1 th\u1eadt.<\/p>\n<p>\u201cCh\u00fang ta \u0111ang b\u01b0\u1edbc v\u00e0o m\u1ed9t k\u1ef7 nguy\u00ean m\u1edbi trong y h\u1ecdc\u201d, Ti\u1ebfn s\u0129 Lloyd Minor, Tr\u01b0\u1edfng khoa Y khoa, ph\u00e1t bi\u1ec3u trong b\u00e0i ph\u00e1t bi\u1ec3u khai m\u1ea1c t\u1ea1i h\u1ed9i ngh\u1ecb chuy\u00ean \u0111\u1ec1 th\u01b0\u1eddng ni\u00ean \u0111\u1ea7u ti\u00ean c\u1ee7a Trung t\u00e2m Y h\u1ecdc X\u00e1c \u0111\u1ecbnh v\u00e0 Ch\u1eefa tr\u1ecb m\u1edbi c\u1ee7a tr\u01b0\u1eddng. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i Stanford \u0111ang s\u1eb5n s\u00e0ng s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c v\u00e0 li\u1ec7u ph\u00e1p gen \u0111\u1ec3 c\u1ea3i thi\u1ec7n nhi\u1ec1u lo\u1ea1i b\u1ec7nh, t\u1eeb nh\u1eefng ch\u1ea9n \u0111o\u00e1n ph\u1ed5 bi\u1ebfn nh\u01b0 ti\u1ec3u \u0111\u01b0\u1eddng v\u00e0 ung th\u01b0 \u0111\u1ebfn c\u00e1c b\u1ec7nh hi\u1ebfm g\u1eb7p v\u1ec1 n\u00e3o, m\u00e1u, da, h\u1ec7 mi\u1ec5n d\u1ecbch v\u00e0 c\u00e1c c\u01a1 quan kh\u00e1c. Cu\u1ed1i c\u00f9ng, m\u1ee5c ti\u00eau l\u00e0 t\u1ea1o ra c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1ed9t l\u1ea7n c\u00f3 th\u1ec3 ch\u1eefa kh\u1ecfi b\u1ec7nh su\u1ed1t \u0111\u1eddi; do \u0111\u00f3, ph\u1ea7n \u201cx\u00e1c \u0111\u1ecbnh v\u00e0 ch\u1eefa tr\u1ecb\u201d trong t\u00ean c\u1ee7a trung t\u00e2m. Stanford l\u00e0 \u0111\u01a1n v\u1ecb d\u1eabn \u0111\u1ea7u trong l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u y h\u1ecdc n\u00e0y, Minor cho bi\u1ebft, \u0111\u1ed3ng th\u1eddi n\u00f3i th\u00eam \u201c\u0110\u00e2y l\u00e0 m\u1ed9t th\u00e0nh ph\u1ea7n quan tr\u1ecdng trong t\u1ea7m nh\u00ecn c\u1ee7a ch\u00fang t\u00f4i v\u1ec1 s\u1ee9c kh\u1ecfe ch\u00ednh x\u00e1c\u201d.<\/p>\n<p>Stanford c\u00f3 b\u1ec1 d\u00e0y l\u1ecbch s\u1eed d\u1eabn \u0111\u1ea7u trong vi\u1ec7c kh\u00e1m ph\u00e1 khoa h\u1ecdc c\u01a1 b\u1ea3n v\u1ec1 sinh h\u1ecdc t\u1ebf b\u00e0o g\u1ed1c, v\u00e0 hi\u1ec7n \u0111ang tham gia nghi\u00ean c\u1ee9u nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c nhau \u0111\u1ec3 nh\u1eefng kh\u00e1m ph\u00e1 n\u00e0y c\u00f3 th\u1ec3 mang l\u1ea1i l\u1ee3i \u00edch cho b\u1ec7nh nh\u00e2n, theo Ti\u1ebfn s\u0129 Maria Grazia Roncarolo, ng\u01b0\u1eddi \u0111\u1ee9ng \u0111\u1ea7u trung t\u00e2m m\u1edbi. &quot;Nhi\u1ec7m v\u1ee5 c\u1ee7a ch\u00fang t\u00f4i l\u00e0 t\u1ea1o ra d\u1eef li\u1ec7u l\u00e2m s\u00e0ng \u0111\u1ee7 s\u1ee9c thuy\u1ebft ph\u1ee5c \u0111\u1ec3 ng\u00e0nh c\u00f4ng nghi\u1ec7p ch\u1ea5p nh\u1eadn s\u1ea3n ph\u1ea9m v\u00e0 \u0111\u01b0a n\u00f3 l\u00ean m\u1ed9t t\u1ea7m cao m\u1edbi&quot;, Roncaraolo ph\u00e1t bi\u1ec3u v\u1edbi kh\u00e1n gi\u1ea3.<\/p>\n<p>Trong s\u1ed1 nh\u1eefng \u0111i\u1ec3m n\u1ed5i b\u1eadt kh\u00e1c c\u1ee7a s\u1ef1 ki\u1ec7n:<\/p>\n<ul>\n<li>B\u00e1c s\u0129 nh\u00e3n khoa Jeffrey Goldberg, Ti\u1ebfn s\u0129, B\u00e1c s\u0129 nh\u00e3n khoa, b\u00e1o c\u00e1o r\u1eb1ng c\u00e1c k\u1ef9 thu\u1eadt t\u1ebf b\u00e0o g\u1ed1c c\u00f3 th\u1ec3 t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o thay th\u1ebf cho c\u00e1c t\u1ebf b\u00e0o b\u1ecb t\u1ed5n th\u01b0\u01a1ng \u1edf l\u1edbp trong c\u1ee7a gi\u00e1c m\u1ea1c. Nh\u00f3m c\u1ee7a \u00f4ng hi\u1ec7n \u0111ang ti\u1ebfn h\u00e0nh c\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng ban \u0111\u1ea7u v\u1edbi c\u00e1c t\u1ebf b\u00e0o gi\u00e1c m\u1ea1c \u0111\u01b0\u1ee3c g\u1eafn m\u1ed9t h\u1ea1t nano t\u1eeb t\u00ednh. C\u00e1c t\u1ebf b\u00e0o t\u1eeb t\u00ednh \u0111\u01b0\u1ee3c ti\u00eam v\u00e0o m\u1eaft v\u00e0 \u0111\u01b0\u1ee3c gi\u1eef c\u1ed1 \u0111\u1ecbnh tr\u00ean gi\u00e1c m\u1ea1c b\u1eb1ng m\u1ed9t mi\u1ebfng che m\u1eaft t\u1eeb t\u00ednh. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u hy v\u1ecdng k\u1ef9 thu\u1eadt n\u00e0y c\u00f3 th\u1ec3 gi\u00fap m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n tr\u00e1nh \u0111\u01b0\u1ee3c vi\u1ec7c gh\u00e9p gi\u00e1c m\u1ea1c.<\/li>\n<li>B\u00e1c s\u0129, Ti\u1ebfn s\u0129, B\u00e1c s\u0129 Huy\u1ebft h\u1ecdc v\u00e0 Ung th\u01b0 Judith Shizuru, ph\u00e1t bi\u1ec3u v\u1edbi kh\u00e1n gi\u1ea3 r\u1eb1ng s\u1ebd c\u00f3 nhi\u1ec1u ng\u01b0\u1eddi \u0111\u01b0\u1ee3c gh\u00e9p t\u1ee7y x\u01b0\u01a1ng h\u01a1n n\u1ebfu quy tr\u00ecnh n\u00e0y kh\u00f4ng c\u1ea7n d\u00f9ng \u0111\u1ebfn thu\u1ed1c h\u00f3a tr\u1ecb \u0111\u1ed9c h\u1ea1i. Trong m\u1ed9t th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng m\u1edbi \u0111\u01b0\u1ee3c tri\u1ec3n khai, Shizuru v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p \u0111ang s\u1eed d\u1ee5ng c\u00e1c k\u1ef9 thu\u1eadt d\u1ef1a tr\u00ean kh\u00e1ng th\u1ec3 thay cho h\u00f3a tr\u1ecb \u0111\u1ec3 chu\u1ea9n b\u1ecb cho tr\u1ebb em m\u1eafc b\u1ec7nh suy gi\u1ea3m mi\u1ec5n d\u1ecbch k\u1ebft h\u1ee3p n\u1eb7ng (c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 &quot;b\u1ec7nh bong b\u00f3ng&quot;) gh\u00e9p t\u1ee7y x\u01b0\u01a1ng.<\/li>\n<li>Ti\u1ebfn s\u0129, B\u00e1c s\u0129 Seung Kim \u0111\u00e3 m\u00f4 t\u1ea3 c\u00e1ch c\u00e1c k\u1ef9 thu\u1eadt nghi\u00ean c\u1ee9u t\u1ebf b\u00e0o g\u1ed1c gi\u00fap hi\u1ec3u r\u00f5 h\u01a1n v\u1ec1 kh\u1ea3 n\u0103ng t\u1ea1o ra c\u00e1c t\u1ebf b\u00e0o beta tuy\u1ebfn t\u1ee5y m\u1edbi cho nh\u1eefng ng\u01b0\u1eddi m\u1eafc b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng lo\u1ea1i 1. Li\u00ean quan \u0111\u1ebfn v\u1ea5n \u0111\u1ec1 n\u00e0y, \u0111\u1ed3ng nghi\u1ec7p c\u1ee7a b\u00e1c s\u0129 Kim, Ti\u1ebfn s\u0129, B\u00e1c s\u0129 Hiromitsu Nakauchi, g\u1ea7n \u0111\u00e2y \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng tuy\u1ebfn t\u1ee5y chu\u1ed9t c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y tr\u00ean chu\u1ed9t c\u1ed1ng v\u00e0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng \u1edf chu\u1ed9t nh\u1eaft.<\/li>\n<li>M\u1eb7c d\u00f9 b\u1ec7nh h\u1ed3ng c\u1ea7u h\u00ecnh li\u1ec1m hi\u1ec7n nay c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p gh\u00e9p t\u1ee7y x\u01b0\u01a1ng, nh\u01b0ng nhi\u1ec1u b\u1ec7nh nh\u00e2n v\u1eabn kh\u00f4ng t\u00ecm \u0111\u01b0\u1ee3c ng\u01b0\u1eddi hi\u1ebfn t\u1eb7ng ph\u00f9 h\u1ee3p, theo b\u00e1c s\u0129 Matthew Porteus, h\u00ecnh tr\u00ean. Ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a \u00f4ng \u0111ang nghi\u00ean c\u1ee9u c\u00e1ch c\u00e1c k\u1ef9 thu\u1eadt ch\u1ec9nh s\u1eeda gen (bao g\u1ed3m c\u1ea3 CRISPR) c\u00f3 th\u1ec3 cho ph\u00e9p c\u00e1c nh\u00e0 khoa h\u1ecdc s\u1eeda ch\u1eefa l\u1ed7i di truy\u1ec1n ti\u1ec1m \u1ea9n tr\u1ef1c ti\u1ebfp trong c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n.<\/li>\n<li>C\u00e1c chuy\u00ean gia v\u1ec1 li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ung th\u01b0 nh\u01b0 Ti\u1ebfn s\u0129 Crystal Mackall \u0111ang n\u1ed7 l\u1ef1c t\u1ea1o ra nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi m\u00e0 ung th\u01b0 kh\u00f4ng th\u1ec3 qua m\u1eb7t. &quot;Tr\u01b0\u1edbc \u0111\u00e2y, ch\u00fang t\u00f4i th\u01b0\u1eddng nh\u1eafm v\u00e0o kh\u1ed1i u b\u1eb1ng thu\u1ed1c \u0111\u1ed9c ho\u1eb7c c\u00e1c t\u00e1c nh\u00e2n \u0111\u00edch&quot;, Mackall n\u00f3i. &quot;\u0110i\u1ec1u \u0111\u00e3 thay \u0111\u1ed5i l\u00e0 ch\u00fang t\u00f4i c\u0169ng c\u00f3 th\u1ec3 nh\u1eafm v\u00e0o v\u1eadt ch\u1ee7 v\u00e0 thay \u0111\u1ed5i c\u00e1ch v\u1eadt ch\u1ee7 ph\u1ea3n \u1ee9ng v\u1edbi kh\u1ed1i u&quot;. Nh\u00f3m c\u1ee7a b\u00e0 \u0111ang thi\u1ebft k\u1ebf t\u1ebf b\u00e0o T, m\u1ed9t lo\u1ea1i t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch, \u0111\u1ec3 k\u00edch th\u00edch c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n ung th\u01b0 t\u1ea5n c\u00f4ng c\u00e1c kh\u1ed1i u \u0111\u00e3 ng\u1eebng \u0111\u00e1p \u1ee9ng v\u1edbi h\u00f3a tr\u1ecb li\u1ec7u truy\u1ec1n th\u1ed1ng. C\u00f4ng tr\u00ecnh c\u1ee7a h\u1ecd v\u1eabn ch\u01b0a th\u00e0nh c\u00f4ng nh\u01b0 mong \u0111\u1ee3i: M\u1ed9t s\u1ed1 t\u1ebf b\u00e0o kh\u1ed1i u c\u00f3 th\u1ec3 tr\u1ed1n tr\u00e1nh t\u1ebf b\u00e0o T v\u00e0 ph\u00e1t tri\u1ec3n tr\u1edf l\u1ea1i. Nh\u01b0ng Mackall v\u1eabn l\u1ea1c quan. &quot;Ch\u00fang ta \u0111ang \u1edf giai \u0111o\u1ea1n cu\u1ed1i c\u1ee7a s\u1ef1 kh\u1edfi \u0111\u1ea7u&quot;, b\u00e0 n\u00f3i.<\/li>\n<\/ul>\n<p>C\u00f3 th\u1ec3 t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00e1c s\u1ef1 ki\u1ec7n trong ng\u00e0y t\u1ea1i <a href=\"http:\/\/www.mercurynews.com\/2017\/02\/07\/stanford-team-is-growing-healthy-skin-for-diseased-patients\/\" target=\"_blank\" rel=\"noopener\">m\u1ed9t c\u00e2u chuy\u1ec7n t\u1eeb t\u1edd San Jose Mercury News<\/a> B\u00e0i vi\u1ebft m\u00f4 t\u1ea3 c\u00e1ch Anthony Oro, Ti\u1ebfn s\u0129, B\u00e1c s\u0129, v\u00e0 c\u00e1c \u0111\u1ed3ng nghi\u1ec7p c\u1ee7a \u00f4ng \u0111ang chi\u1ebfn \u0111\u1ea5u v\u1edbi b\u1ec7nh ly th\u01b0\u1ee3ng b\u00ec b\u00f3ng n\u01b0\u1edbc, m\u1ed9t c\u0103n b\u1ec7nh di truy\u1ec1n nguy hi\u1ec3m v\u1ec1 da. Oro k\u1ebft th\u00fac b\u00e0i n\u00f3i chuy\u1ec7n b\u1eb1ng m\u1ed9t b\u1ee9c \u1ea3nh h\u01a1i ng\u1edb ng\u1ea9n v\u1ec1 m\u1ed9t ng\u01b0\u1eddi \u0111\u00e0n \u00f4ng \u0111ang x\u1ecbt r\u00e1m n\u1eafng. B\u1ee9c \u1ea3nh khi\u1ebfn m\u1ecdi ng\u01b0\u1eddi b\u1eadt c\u01b0\u1eddi, nh\u01b0ng quan \u0111i\u1ec3m c\u1ee7a \u00f4ng r\u1ea5t nghi\u00eam t\u00fac: &quot;M\u1ee5c ti\u00eau c\u1ee7a ch\u00fang t\u00f4i cho li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o trong t\u01b0\u01a1ng lai l\u00e0 x\u1ecbt l\u00ean da \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb m\u1ed9t c\u0103n b\u1ec7nh di truy\u1ec1n kh\u1ee7ng khi\u1ebfp.&quot;<\/p>\n<p>Tham v\u1ecdng \u01b0? \u0110\u00fang v\u1eady. Khoa h\u1ecdc vi\u1ec5n t\u01b0\u1edfng \u01b0? T\u01b0\u01a1ng lai th\u00ec c\u00f3 l\u1ebd kh\u00f4ng.<\/p>\n<p><em>C\u00e2u chuy\u1ec7n n\u00e0y ban \u0111\u1ea7u xu\u1ea5t hi\u1ec7n tr\u00ean <a href=\"http:\/\/scopeblog.stanford.edu\/2017\/02\/09\/stanford-scientists-describe-stem-cell-and-gene-therapy-advances-in-scientific-symposium\/\" target=\"_blank\" rel=\"noopener\">PH\u1ea0M VI<\/a>.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Vi\u1ec7c s\u1eed d\u1ee5ng t\u1ebf b\u00e0o g\u1ed1c v\u00e0 li\u1ec7u ph\u00e1p gen \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ho\u1eb7c ch\u1eefa b\u1ec7nh c\u00f3 v\u1ebb v\u1eabn gi\u1ed1ng nh\u01b0 khoa h\u1ecdc vi\u1ec5n t\u01b0\u1edfng, nh\u01b0ng m\u1ed9t cu\u1ed9c h\u1ecdp khoa h\u1ecdc g\u1ea7n \u0111\u00e2y \u0111\u00e3 nh\u1ea5n m\u1ea1nh t\u1ea5t c\u1ea3\u2026<\/p>","protected":false},"author":17,"featured_media":14834,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[148],"class_list":["post-3888","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-the-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - 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