{"id":4309,"date":"2022-11-14T19:57:35","date_gmt":"2022-11-14T19:57:35","guid":{"rendered":"https:\/\/lpfch.org\/sergiu-pasca-md-is-revolutionizing-research-into-neuropsychiatric-disorders\/"},"modified":"2024-06-20T16:07:52","modified_gmt":"2024-06-20T16:07:52","slug":"sergiu-pasca-md-is-revolutionizing-research-into-neuropsychiatric-disorders","status":"publish","type":"post","link":"https:\/\/lpfch.org\/vi\/impact-stories\/sergiu-pasca-md-is-revolutionizing-research-into-neuropsychiatric-disorders\/","title":{"rendered":"Ti\u1ebfn s\u0129 Sergiu Pasca \u0111ang c\u00e1ch m\u1ea1ng h\u00f3a nghi\u00ean c\u1ee9u v\u1ec1 c\u00e1c r\u1ed1i lo\u1ea1n th\u1ea7n kinh"},"content":{"rendered":"<p>Hi\u1ec7n ch\u01b0a c\u00f3 c\u00e1ch ch\u1eefa kh\u1ecfi H\u1ed9i ch\u1ee9ng m\u1ea5t \u0111o\u1ea1n 22q11.2. Nh\u00e0 nghi\u00ean c\u1ee9u Sergiu Pasca c\u1ee7a \u0110\u1ea1i h\u1ecdc Stanford, Ti\u1ebfn s\u0129 Y khoa, mu\u1ed1n thay \u0111\u1ed5i \u0111i\u1ec1u \u0111\u00f3.<\/p>\n<p>Th\u00f4ng th\u01b0\u1eddng, vi\u1ec7c hi\u1ec3u c\u00e1ch c\u00e1c t\u1ebf b\u00e0o ho\u1ea1t \u0111\u1ed9ng l\u00e0 ch\u00eca kh\u00f3a \u0111\u1ec3 gi\u00fap b\u1ec7nh nh\u00e2n. V\u00ed d\u1ee5, vi\u1ec7c ki\u1ec3m tra t\u1ebf b\u00e0o kh\u1ed1i u ung th\u01b0 d\u01b0\u1edbi k\u00ednh hi\u1ec3n vi c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb \u0111\u00edch. Tuy nhi\u00ean, c\u00e1c b\u1ec7nh l\u00fd th\u1ea7n kinh t\u00e2m th\u1ea7n nh\u01b0 t\u1ef1 k\u1ef7 v\u00e0 t\u00e2m th\u1ea7n ph\u00e2n li\u1ec7t v\u1eabn \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n nh\u01b0 c\u00e1ch ch\u00fang \u0111\u00e3 l\u00e0m trong h\u01a1n m\u1ed9t th\u1ebf k\u1ef7 qua, ch\u1ee7 y\u1ebfu d\u1ef1a tr\u00ean h\u00e0nh vi c\u1ee7a b\u1ec7nh nh\u00e2n.<\/p>\n<p>Pasca\u2014ng\u01b0\u1eddi \u0111\u01b0\u1ee3c \u0111\u00e0o t\u1ea1o l\u00e0m b\u00e1c s\u0129 \u1edf Romania v\u00e0 \u0111\u1ebfn Stanford v\u00e0o n\u0103m 2009 \u0111\u1ec3 \u0111\u00e0o t\u1ea1o sau ti\u1ebfn s\u0129\u2014c\u1ea3m th\u1ea5y th\u1ea5t v\u1ecdng v\u00ec c\u01a1 ch\u1ebf c\u01a1 b\u1ea3n c\u1ee7a nhi\u1ec1u t\u00ecnh tr\u1ea1ng n\u00e3o v\u1eabn c\u00f2n l\u00e0 m\u1ed9t b\u00ed \u1ea9n.<\/p>\n<p>V\u00ec v\u1eady, Pasca \u0111\u00e3 t\u1ea1m d\u1eebng vi\u1ec7c kh\u00e1m b\u1ec7nh \u0111\u1ec3 t\u1eadp trung v\u00e0o nghi\u00ean c\u1ee9u. &quot;T\u00f4i t\u1ef1 \u0111\u1eb7t ra h\u1ea1n ch\u00f3t cho m\u00ecnh l\u00e0 n\u1ebfu trong 15 n\u0103m nghi\u00ean c\u1ee9u c\u01a1 b\u1ea3n, t\u00f4i c\u00f3 th\u1ec3 t\u1ea1o ra t\u00e1c \u0111\u1ed9ng l\u1edbn h\u01a1n, t\u00f4i s\u1ebd ti\u1ebfp t\u1ee5c l\u00e0m vi\u1ec7c n\u00e0y&quot;, \u00f4ng n\u00f3i. &quot;N\u1ebfu kh\u00f4ng, t\u00f4i s\u1ebd quay l\u1ea1i v\u00e0 h\u00e0nh ngh\u1ec1 y to\u00e0n th\u1eddi gian.&quot;<\/p>\n<p>Vi\u1ec7c chuy\u1ec3n \u0111\u1ed5i h\u01b0\u1edbng \u0111i \u0111\u00e3 mang l\u1ea1i k\u1ebft qu\u1ea3 khi Pasca l\u00e0 ng\u01b0\u1eddi ti\u00ean phong trong vi\u1ec7c t\u1ea1o ra c\u00e1c m\u00f4 h\u00ecnh n\u00e3o b\u1ed9 con ng\u01b0\u1eddi ti\u00ean ti\u1ebfn nh\u1ea5t \u0111ang l\u00e0m thay \u0111\u1ed5i n\u1ec1n y h\u1ecdc.<\/p>\n<p>Ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a \u00f4ng thu th\u1eadp t\u1ebf b\u00e0o da t\u1eeb b\u1ec7nh nh\u00e2n t\u00e2m th\u1ea7n kinh v\u00e0 l\u1eadp tr\u00ecnh l\u1ea1i ch\u00fang th\u00e0nh t\u1ebf b\u00e0o g\u1ed1c. Ti\u1ebfp theo, \u00f4ng t\u1eadp h\u1ee3p c\u00e1c t\u1ebf b\u00e0o n\u00e0y th\u00e0nh c\u00e1c m\u00f4 nu\u00f4i c\u1ea5y 3D - g\u1ecdi l\u00e0 organoid - v\u00e0 h\u01b0\u1edbng d\u1eabn ch\u00fang bi\u1ec7t h\u00f3a \u0111\u1ec3 gi\u1ed1ng v\u1edbi c\u00e1c b\u1ed9 ph\u1eadn c\u1ee5 th\u1ec3 c\u1ee7a n\u00e3o.<\/p>\n<p>Nh\u1eefng m\u00f4 h\u00ecnh s\u1ed1ng n\u00e0y c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c nu\u00f4i trong \u0111\u0129a trong nhi\u1ec1u n\u0103m, cung c\u1ea5p th\u00f4ng tin chi ti\u1ebft v\u1ec1 s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a n\u00e3o b\u1ed9.<\/p>\n<p>Pasca, gi\u00e1m \u0111\u1ed1c c\u1ee7a c\u00f4ng ty, cho bi\u1ebft: &quot;Ch\u00fang t\u00f4i c\u0169ng \u0111\u00e3 ph\u00e1t tri\u1ec3n c\u00e1c m\u00f4 h\u00ecnh ph\u1ee9c t\u1ea1p h\u01a1n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 assembloid, cho ph\u00e9p ch\u00fang t\u00f4i xem x\u00e9t s\u1ef1 giao ti\u1ebfp gi\u1eefa c\u00e1c v\u00f9ng n\u00e3o kh\u00e1c nhau&quot;.\u00a0<em>Bonnie Uytengsu &amp; Gi\u00e1m \u0111\u1ed1c Gia \u0111\u00ecnh c\u1ee7a Ch\u01b0\u01a1ng tr\u00ecnh Ph\u00e1t tri\u1ec3n C\u01a1 quan N\u00e3o b\u1ed9 Stanford<\/em>\u00a0t\u1ea1i Vi\u1ec7n Khoa h\u1ecdc Th\u1ea7n kinh Wu Tsai. C\u00e1c m\u00f4 h\u00ecnh c\u1ee7a \u00f4ng \u0111\u00e3 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 hi\u1ec3u bi\u1ebft c\u1ee7a ch\u00fang ta v\u1ec1 h\u1ed9i ch\u1ee9ng Timothy, m\u1ed9t d\u1ea1ng t\u1ef1 k\u1ef7 hi\u1ebfm g\u1eb7p. &quot;T\u00f4i hy v\u1ecdng r\u1eb1ng ch\u00fang ta s\u1ebd s\u1edbm ti\u1ebfn t\u1edbi m\u1ed9t chi\u1ebfn l\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb&quot;, Pasca n\u00f3i.<\/p>\n<p>Ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a \u00f4ng hi\u1ec7n hy v\u1ecdng s\u1ebd kh\u00e1m ph\u00e1 ra ngu\u1ed3n g\u1ed1c c\u1ee7a 22q11.2DS. &quot;Ch\u00fang ta m\u1edbi ch\u1ec9 b\u1eaft \u0111\u1ea7u hi\u1ec3u \u0111\u01b0\u1ee3c c\u0103n b\u1ec7nh n\u00e0y&quot;, \u00f4ng n\u00f3i, l\u01b0u \u00fd r\u1eb1ng c\u00f3 h\u01a1n 60 gen li\u00ean quan.<\/p>\n<p>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1eeb kh\u1eafp n\u01a1i tr\u00ean th\u1ebf gi\u1edbi \u0111\u00e3 li\u00ean h\u1ec7 v\u1edbi Ch\u01b0\u01a1ng tr\u00ecnh Ph\u00e1t tri\u1ec3n C\u01a1 quan N\u00e3o b\u1ed9 Stanford \u0111\u1ec3 t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 c\u00f4ng tr\u00ecnh c\u1ee7a Pasca. Ph\u00f2ng th\u00ed nghi\u1ec7m c\u0169ng ch\u00e0o \u0111\u00f3n sinh vi\u00ean qu\u1ed1c t\u1ebf tham gia c\u00e1c h\u1ed9i th\u1ea3o k\u00e9o d\u00e0i m\u1ed9t tu\u1ea7n. &quot;N\u00f3 gi\u1ed1ng nh\u01b0 m\u1ed9t ch\u01b0\u01a1ng tr\u00ecnh ki\u1ec3u Martha Stewart, n\u01a1i h\u1ecd \u0111\u01b0\u1ee3c ch\u1ee9ng ki\u1ebfn ch\u00ednh x\u00e1c m\u1ecdi th\u1ee9 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n nh\u01b0 th\u1ebf n\u00e0o&quot;, Pasca n\u00f3i. &quot;Tuy nhi\u00ean, h\u1ecd ph\u1ea3i cam k\u1ebft r\u1eb1ng h\u1ecd s\u1ebd ho\u1ea1t \u0111\u1ed9ng nh\u01b0 nh\u1eefng \u0111\u1ea1i s\u1ee9 v\u00e0 gi\u1ea3ng d\u1ea1y cho nh\u1eefng ng\u01b0\u1eddi kh\u00e1c t\u1ea1i c\u00e1c c\u01a1 s\u1edf c\u1ee7a m\u00ecnh.&quot;<\/p>\n<p>Khi th\u1eddi h\u1ea1n 15 n\u0103m \u0111ang \u0111\u1ebfn g\u1ea7n, Pasca t\u1ecf ra l\u1ea1c quan. &quot;C\u00f4ng tr\u00ecnh c\u1ee7a ch\u00fang t\u00f4i \u0111\u00e3 gi\u00fap nhi\u1ec1u ng\u01b0\u1eddi kh\u00e1c kh\u00e1m ph\u00e1 ra nh\u1eefng b\u00ed \u1ea9n sinh h\u1ecdc c\u1ee7a n\u00e3o b\u1ed9 con ng\u01b0\u1eddi&quot;, \u00f4ng n\u00f3i. &quot;Ch\u00fang t\u00f4i hy v\u1ecdng \u0111i\u1ec1u n\u00e0y s\u1ebd d\u1eabn \u0111\u1ebfn nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi.&quot;<\/p>\n<p>&nbsp;<\/p>\n<p>\u0110\u1ec3 t\u00ecm hi\u1ec3u th\u00eam v\u1ec1 22q11.2DS, h\u00e3y \u0111\u1ecdc\u00a0<em><a href=\"https:\/\/supportlpch.org\/blog\/unraveling-mysteries-22q112-deletion-syndrome\">Gi\u1ea3i m\u00e3 nh\u1eefng b\u00ed \u1ea9n c\u1ee7a h\u1ed9i ch\u1ee9ng m\u1ea5t \u0111o\u1ea1n 22q11.2<\/a>.<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Kh\u00f4ng c\u00f3 c\u00e1ch ch\u1eefa tr\u1ecb H\u1ed9i ch\u1ee9ng m\u1ea5t \u0111o\u1ea1n 22q11.2. Nh\u00e0 nghi\u00ean c\u1ee9u Sergiu Pasca c\u1ee7a \u0110\u1ea1i h\u1ecdc Stanford mu\u1ed1n thay \u0111\u1ed5i \u0111i\u1ec1u \u0111\u00f3. Th\u00f4ng th\u01b0\u1eddng, vi\u1ec7c hi\u1ec3u c\u00e1ch t\u1ebf b\u00e0o ho\u1ea1t \u0111\u1ed9ng l\u00e0 ch\u00eca kh\u00f3a \u0111\u1ec3\u2026<\/p>","protected":false},"author":17,"featured_media":17597,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[164],"class_list":["post-4309","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","health_topic-mental-health","health_topic-neurology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.3) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sergiu Pasca, MD, Is Revolutionizing Research into Neuropsychiatric Disorders - Lucile Packard Foundation for Children&#039;s Health<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/lpfch.org\/vi\/impact-stories\/sergiu-pasca-md-is-revolutionizing-research-into-neuropsychiatric-disorders\/\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sergiu Pasca, MD, Is Revolutionizing Research into Neuropsychiatric Disorders\" \/>\n<meta property=\"og:description\" content=\"There is no cure for 22q11.2 Deletion Syndrome. 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