{"id":20948,"date":"2025-05-16T17:00:05","date_gmt":"2025-05-16T17:00:05","guid":{"rendered":"https:\/\/lpfch.org\/?p=20948"},"modified":"2025-05-22T18:17:30","modified_gmt":"2025-05-22T18:17:30","slug":"supercharging-car-t-cell-therapy","status":"publish","type":"post","link":"https:\/\/lpfch.org\/zh\/impact-stories\/supercharging-car-t-cell-therapy\/","title":{"rendered":"\u589e\u5f3aCAR-T\u7ec6\u80de\u7597\u6cd5"},"content":{"rendered":"

\u8fc7\u53bb50\u5e74\u6765\uff0c\u7814\u7a76\u4eba\u5458\u5728\u513f\u7ae5\u764c\u75c7\u6cbb\u7597\u65b9\u9762\u53d6\u5f97\u4e86\u4ee4\u4eba\u77a9\u76ee\u7684\u8fdb\u5c55\u300220\u4e16\u7eaa70\u5e74\u4ee3\u4e2d\u671f\uff0c\u7ea6\u6709601\u4f8b\uff08TP3T\uff09\u5e74\u8f7b\u764c\u75c7\u60a3\u8005\u6b7b\u4e8e\u764c\u75c7\uff0c\u800c\u5982\u4eca\uff0c\u5df2\u6709851\u4f8b\uff08TP3T\uff09\u60a3\u8005\u5b58\u6d3b\u4e0b\u6765\u3002\u8fd9\u4e00\u8fdb\u5c55\u79bb\u4e0d\u5f00\u50cf\u65af\u5766\u798f\u9732\u897f\u5c14\u00b7\u5e15\u5361\u5fb7\u513f\u7ae5\u533b\u9662\u8fd9\u6837\u7684\u5b66\u672f\u533b\u7597\u4e2d\u5fc3\u4e3b\u5bfc\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/span>\u00a0<\/span><\/p>\n

\u5c3d\u7ba1\u53d6\u5f97\u4e86\u8fd9\u4e9b\u8fdb\u5c55\uff0c\u764c\u75c7\u4ecd\u7136\u662f15\u5c81\u53ca\u4ee5\u4e0b\u513f\u7ae5\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u5bf9\u4e8e\u90a3\u4e9b\u53ef\u4ee5\u6cbb\u6108\u7684\u60a3\u8005\u6765\u8bf4\uff0c\u4e25\u82db\u7684\u6cbb\u7597\u5f80\u5f80\u4f1a\u5728\u65e5\u540e\u5f15\u53d1\u5065\u5eb7\u95ee\u9898\uff0c\u4f8b\u5982\u5668\u5b98\u635f\u5bb3\u3001\u4e0d\u5b55\u4e0d\u80b2\u6216\u7ee7\u53d1\u6027\u764c\u75c7\u3002<\/span>\u00a0<\/span><\/p>\n

\"\"<\/a><\/p>\n

\u63d2\u56fe\uff1aAlece Birnbach<\/em><\/p>\n

\u78b3<\/span>rystal Mackall \u533b\u5b66\u535a\u58eb <\/span>\u6b27\u5185\u65af\u7279\u548c\u963f\u7c73\u8389\u4e9a\u00b7\u52a0\u6d1b\u5bb6\u65cf\u6559\u6388\uff0c <\/span><\/i>\u513f\u79d1\u548c\u533b\u5b66\u6559\u6388\uff0c\u4ee5\u53ca\u4e2d\u5fc3<\/span> \u5e15\u514b\u764c\u75c7\u7814\u7a76\u6240\u6240\u957f<\/span> \u65af\u5766\u798f\u533b\u5b66\u9662\u7684\u514d\u75ab\u7597\u6cd5\u6b63\u5728\u5f15\u9886<\/span> \u4e3a\u6700\u9700\u8981\u5e2e\u52a9\u7684\u5b69\u5b50\u4eec\u5e26\u6765\u5e0c\u671b\u3002\u66f4\u591a\u4fe1\u606f<\/span> 40 \u591a\u5e74\u6765\uff0cMackall \u4e00\u76f4\u662f\u764c\u75c7\u7814\u7a76\u9886\u57df\u7684\u5148\u9a71<\/span> \u514d\u75ab\u7597\u6cd5\u2014\u2014\u5229\u7528\u4eba\u4f53\u81ea\u8eab<\/span> \u514d\u75ab\u7ec6\u80de\u5bf9\u6297\u75be\u75c5\u30022017 \u5e74\uff0cMackall \u63a8\u51fa\u4e86<\/span> \u65af\u5766\u798f\u5927\u5b66\u764c\u75c7\u7ec6\u80de\u6cbb\u7597\u4e2d\u5fc3\u63a8\u52a8<\/span> \u4ece\u5b9e\u9a8c\u5ba4\u5230\u60a3\u8005\u5e8a\u8fb9\u7684\u7a81\u7834<\/span> \u5c3d\u5feb\u3002<\/span>\u00a0<\/span><\/p>\n

\u201c\u5728\u6211\u770b\u6765\uff0c\u65af\u5766\u798f\u662f\u4e16\u754c\u4e0a\u6700\u5177\u521b\u9020\u529b\u7684\u79d1\u7814\u4e4b\u5730\uff0c\u201d\u9ea6\u5361\u5c14\u8bf4\u9053\u3002\u201c\u6211\u60f3\u5728\u8fd9\u91cc\u5f00\u53d1\u7ec6\u80de\u7597\u6cd5\uff0c\u56e0\u4e3a\u6211\u77e5\u9053\u6211\u80fd\u4e0e\u4e00\u4e9b\u6700\u6770\u51fa\u7684\u4eba\u624d\u5171\u4e8b\u2014\u2014\u4ed6\u4eec\u5bf9\u5408\u6210\u751f\u7269\u5b66\u3001\u4eba\u5de5\u667a\u80fd\u3001\u8f6c\u5316\u7814\u7a76\u548c\u4eba\u7c7b\u514d\u75ab\u5b66\u7b49\u9886\u57df\u5145\u6ee1\u5174\u8da3\u3002\u201d<\/span>\u00a0<\/span><\/p>\n

Mackall \u7684\u56e2\u961f\u6b63\u5728\u5f15\u9886\u5d4c\u5408\u6297\u539f\u53d7\u4f53 (CAR) T \u7ec6\u80de\u7597\u6cd5\u7684\u9769\u547d\u6027\u6539\u8fdb\u3002\u8fd9\u79cd\u65b9\u6cd5\u5bf9\u67d0\u4e9b\u8840\u764c\u7597\u6548\u663e\u8457\uff0c\u5b83\u80fd\u591f\u6539\u9020\u60a3\u8005\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u4f7f\u5176\u80fd\u591f\u5bfb\u627e\u5e76\u6467\u6bc1\u764c\u7ec6\u80de\u3002\u76ee\u524d\uff0cMackall \u6b63\u81f4\u529b\u4e8e\u4f7f\u8fd9\u79cd\u7597\u6cd5\u5bf9\u5b9e\u4f53\u764c\u548c\u8111\u80bf\u7624\u6709\u6548\uff0c\u91cd\u70b9\u5173\u6ce8\u513f\u7ae5\u60a3\u8005\u3002Mackall \u4e0e Michelle Monje \u535a\u58eb\uff08\u533b\u5b66\u535a\u58eb\u3001\u54f2\u5b66\u535a\u58eb\uff09\u5408\u4f5c\uff0cMichelle Monje \u535a\u58eb\u662f <\/span>Milan Gambhir \u513f\u79d1\u795e\u7ecf\u80bf\u7624\u5b66\u6559\u6388\uff0c <\/span><\/i>\u4f7f\u7528 CAR T \u7ec6\u80de\u6cbb\u7597\u5f25\u6f2b\u6027\u5185\u5728\u6027\u8111\u6865\u795e\u7ecf\u80f6\u8d28\u7624\u53d6\u5f97\u4e86\u91cd\u5927\u7a81\u7834\uff0c\u5f25\u6f2b\u6027\u8111\u6865\u795e\u7ecf\u80f6\u8d28\u7624\u662f\u4e00\u79cd\u513f\u7ae5\u8111\u80bf\u7624\uff0c\u76f4\u5230\u73b0\u5728\u624d\u88ab\u8ba4\u4e3a\u662f\u666e\u904d\u81f4\u547d\u7684\u3002<\/span>\u00a0<\/span><\/p>\n

\u8fd9\u4e00\u7a81\u7834\u5f97\u76ca\u4e8e\u5e7f\u6cdb\u7684\u6350\u52a9\u652f\u6301\uff0c\u800c\u9ea6\u8003\u5c14\u6df1\u77e5\u8fd9\u4ec5\u4ec5\u662f\u4e2a\u5f00\u59cb\u3002\u5979\u6b63\u5728\u5f00\u53d1\u6240\u8c13\u7684\u201c\u4e0b\u4e00\u4ee3\u201d\u514d\u75ab\u7597\u6cd5\u2014\u2014\u5728\u73b0\u6709\u6280\u672f\u7684\u57fa\u7840\u4e0a\uff0c\u4f7f\u514d\u75ab\u7597\u6cd5\u66f4\u5b89\u5168\u3001\u66f4\u6709\u6548\u3001\u66f4\u7ecf\u6d4e\u3002<\/span>\u00a0<\/span><\/p>\n

\u5176\u4e2d\u4e00\u9879\u521b\u65b0\u65e8\u5728\u63d0\u9ad8CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u7597\u6548\u3001\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002Mackall\u548c\u5979\u7684\u56e2\u961f\u53d1\u73b0\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5229\u7528\u4e00\u79cd\u73b0\u6709\u836f\u7269\u2014\u2014\u4e00\u79cdFDA\u6279\u51c6\u7684\u809d\u708e\u836f\u7269\u2014\u2014\u5728\u5c06CAR-T\u7ec6\u80de\u6ce8\u5165\u60a3\u8005\u4f53\u5185\u540e\uff0c\u5c06\u5176\u201c\u6fc0\u6d3b\u201d\u3002<\/span>'<\/span><\/i>\u7684\u8eab\u4f53\u3002\u8fd9\u79cd\u88ab\u79f0\u4e3a\u201cSNIP CAR T\u201d\u7684\u65b0\u65b9\u6cd5\u4f7f\u4ed6\u4eec\u4e0d\u4ec5\u80fd\u591f\u63a7\u5236\u6cbb\u7597\u7684\u65f6\u95f4\u548c\u5730\u70b9\uff0c\u8fd8\u80fd\u63a7\u5236\u6cbb\u7597\u7684\u6fc0\u6d3b\u7a0b\u5ea6\u3002<\/span>\u00a0<\/span><\/p>\n

Mackall \u89e3\u91ca\u8bf4\uff1a\u201c\u6211\u4eec\u521b\u9020\u4e86\u4e00\u79cd\u2018\u8fdc\u7a0b\u63a7\u5236\u2019\u7684 CAR-T \u7ec6\u80de\u7597\u6cd5\uff0c\u53ef\u4ee5\u6839\u636e\u6bcf\u4f4d\u60a3\u8005\u7684\u60c5\u51b5\u8fdb\u884c\u8c03\u6574\u3002\u6539\u826f\u7684 CAR-T \u7ec6\u80de\u4e0d\u4ec5\u66f4\u5b89\u5168\uff0c\u800c\u4e14\u6bd4\u539f\u6765\u7684 CAR-T \u7ec6\u80de\u66f4\u6709\u6548\u3001\u7528\u9014\u66f4\u5e7f\u6cdb\u3002\u201d<\/span>\u00a0<\/span><\/p>\n

\u50cf\u9ea6\u8003\u5c14\u8fd9\u6837\u7684\u5c16\u7aef\u79d1\u5b66\u9700\u8981\u6709\u8fdc\u89c1\u7684\u6295\u8d44\u8005\u7684\u5927\u529b\u652f\u6301\u3002\u7136\u800c\uff0c\u901a\u8fc7\u4f20\u7edf\u7684\u8d44\u91d1\u6e20\u9053\u5f88\u96be\u83b7\u5f97\u8fd9\u79cd\u652f\u6301\u3002<\/span>\u00a0<\/span><\/p>\n

\u5979\u89e3\u91ca\u8bf4\uff1a\u201c\u98ce\u9669\u6295\u8d44\u548c\u751f\u7269\u5236\u836f\u516c\u53f8\u901a\u5e38\u4e0d\u4f1a\u6295\u8d44\u7f55\u89c1\u75c5\uff0c\u800c\u6240\u6709\u513f\u7ae5\u764c\u75c7\u90fd\u662f\u7f55\u89c1\u75c5\u3002\u4f46\u6211\u4eec\u7684\u76ee\u6807\u662f\u8fdb\u884c\u98a0\u8986\u6027\u79d1\u5b66\u7814\u7a76\u3002\u6211\u4eec\u5e0c\u671b\u6539\u53d8\u672a\u6765\u60a3\u8005\u7684\u6cbb\u7597\u65b9\u5f0f\u3002\u201d<\/span>\u00a0<\/span><\/p>\n

\u6148\u5584\u652f\u6301\u50ac\u5316\u4e86\u9ea6\u5361\u5c14\u7684\u53d1\u73b0\uff0c\u5bf9\u5979\u672a\u6765\u7684\u53d1\u5c55\u81f3\u5173\u91cd\u8981\u3002\u50cf\u514b\u91cc\u65af\u00b7\u52a0\u6d1b\uff08Chris Gallo\uff09\u8fd9\u6837\u7684\u6350\u8d60\u8005\u2014\u2014\u4ed6\u7684\u5bb6\u65cf\u4e3a\u9ea6\u5361\u5c14\u8bbe\u7acb\u4e86\u6350\u8d60\u6559\u6388\u804c\u4f4d\u2014\u2014\u81f4\u529b\u4e8e\u652f\u6301\u5979\u7684\u91cd\u8981\u5de5\u4f5c\u3002\u52a0\u6d1b\u6df1\u77e5\uff0c\u5982\u679c\u5176\u4ed6\u6148\u5584\u5bb6\u52a0\u5165\u8fdb\u6765\uff0c\u8fdb\u6b65\u5c06\u4f1a\u66f4\u5feb\u3002<\/span>\u00a0<\/span><\/p>\n

\u201c\u6211\u4eec\u5bb6\u65cf\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u652f\u6301\u50cf\u9ea6\u5361\u5c14\u535a\u58eb\u8fd9\u6837\u7684\u5c16\u7aef\u79d1\u5b66\u2014\u2014\u8fd9\u4e9b\u7814\u7a76\u65e8\u5728\u4e3a\u513f\u7ae5\u5e26\u6765\u66f4\u597d\u7684\u6cbb\u7597\uff0c\u201d\u52a0\u6d1b\u8bf4\u9053\u3002\u201c\u6211\u4eec\u5f88\u81ea\u8c6a\u80fd\u591f\u901a\u8fc7\u6148\u5584\u4e8b\u4e1a\u5ef6\u7eed\u8fd9\u4e00\u4f20\u7edf\u3002\u201d<\/span>\u00a0<\/span><\/p>\n

\u51ed\u501f\u5f00\u521b\u6027\u7684\u6210\u529f\u548c\u65e0\u9650\u7684\u53ef\u80fd\u6027\uff0c\u9ea6\u5361\u5c14\u6b63\u5728\u4e3a\u533b\u5b66\u65b0\u65f6\u4ee3\u548c\u513f\u7ae5\u66f4\u5065\u5eb7\u7684\u672a\u6765\u89c4\u5212\u65b9\u5411\u3002<\/span>\u00a0<\/span><\/p>\n

<\/span><\/p>","protected":false},"excerpt":{"rendered":"

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