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Learn about our groundbreaking clinical trial and how you can help kids in London with food allergies.Find cures and transform lives >

Uniting universities across California, and now, internationally
in London, the Sean N. Parker Center for Allergy and Asthma Research at Stanford University
is thrilled to announce expansion of a first-of-its-kind clinical study: the COMBINE trial.
This groundbreaking therapy has an innovative approach to treating food allergies
once and for all.

The COMBINE study aims to evaluate the
effect and tolerability of omalizumab in combination with dupilumab on enhancing the
efficacy and safety of OIT in patients with multi-food allergies with two treatments:
lowering the free IgE antibody levels (omalizumab) and inhibiting IL-4 and IL-13 signaling
(dupilumab). A breakthrough phase 2 multi-allergen study that uses two biologics at the
same time; one to get rid of food allergies, and the other to make sure they
don’t return.
A multi-site trial enrolling patients from across
the U.K., this will complement the Center’s existing trial with patients at
University of California, Los Angeles and University of California, San Diego. We expect
the trial to take three years from beginning to end, with individual treatment for each
enrolled participant lasting nine months. The trial consists of three cohorts, each of
which will receive multifood allergen oral immunotherapy and one or both of the biologics
omalizumab or dupilumab. 

This Is Where You Come

Our goal is ambitious. With $4 million urgently needed to
start this important work, your donation will help unlock more care for kids with
food allergies and build the infrastructure needed to expand access. Your philanthropic
investment in food allergy research means more kids will have access to the crucial
treatment that they need, leading to a bright and endless future. Schedule a
call with our team today (Lindsey Hincks or Laura
 to learn how your generosity will be the
bedrock for future clinical trials in London.

Are you ready to make a big impact and
transform lives

Patient Highlight: Dean, age

Meet Dean, a former food allergy patient who participated in
a clinical trial at the Sean N. Parker Center for Allergy and Asthma Research at Stanford
University. Faced with certain foods known to cause life-threatening allergic reactions,
Dean came into the trial feeling scared. But the expert care team members at the Allergy
Center calmed his fears and made him feel safe. Thanks to supporters like
you, Dean is now able to embrace a more adventurous lifestyle—camping, fishing,
and other outdoor activities—because of his increased tolerance to certain

In this video, Dean recently caught up with Sharon
Chinthrajah, MD, from the Allergy Center. Watch the inspiring interview as they discuss
everything from Dr. Chinthrajah's super powers to what innovative new trials and
therapies, such as the COMBINE Trial, are on the horizon to help more kids like


Dr. Kari Nadeau

Kari Nadeau is Director of the Sean N. Parker Center for Allergy and Asthma Research at
Stanford University and the Naddisy Foundation Professor of Pediatric Food Allergy,
Immunology, and Asthma at the Stanford University School of Medicine. As one of the
world’s foremost experts in adult and pediatric allergy, immunology, and asthma,
she is laying the groundwork for a variety of potential future therapies to prevent and
cure allergies and asthma.

Dr. Gideon Lack

Gideon Lack is Professor of Paediatric Allergy at King’s College London and Head
of the Children’s Allergy Service at Guy’s and St Thomas’ NHS
Foundation Trust. He has established two of the nation’s five paediatric allergy
centres and is a co-founder of the Allergy Academy at King’s. His research
focuses on the prevalence of food allergies in children and the relationship between food
allergies, eczema, and asthma.

Dr. Helen Brough

Helen Brough leads the Children’s Allergy Service at Evelina London
Children’s Healthcare, the largest Children’s Allergy Service in the UK
and one of the largest in Europe. She runs general allergy clinics, community-based allergy
clinics, transition allergy clinics for adolescents, and the specialist difficult asthma
and allergy service. She is actively involved in research to improve the prevention,
diagnosis, and treatment of food allergy.